Migraine is a chronic neurovascular disorder characterised by recurrent attacks of moderate-to-severe head pain, accompanied by transient but disabling symptoms such as aura, nausea, vomiting, phonoph...

Idiopathic intracranial hypertension is a condition characterised by a potentially sight-threatening increase in intracranial pressure with no known cause, and it is strongly associated with obesity i...

The exploratory geometry-driven deep learning approach used in this study proposes to describe brain changes across multiple scales by integrating structural and functional information and predicts br...

Flortaucipir uptake in FTLD-TDP, particularly type C, could reflect off-target binding to phosphorylated TDP-43 and ANXA11 aggregates in limbic regions rather than tau pathology alone; consequently, t...

Explore the current issue of The Lancet Neurology, a monthly journal covering international issues relevant to neurologists worldwide

Explore the current issue of The Lancet Neurology, a monthly journal covering international issues relevant to neurologists worldwide

Explore the current issue of The Lancet Neurology, a monthly journal covering international issues relevant to neurologists worldwide

Lecanemab treatment was associated with dynamic, multidirectional changes across plasma biomarkers of Alzheimer's disease pathology, with partial normalisation of amyloid and tau biomarkers alongside ...

Prevalence of UIA is increasing, particularly over the past two decades. This increase is only in part explained by improved detection of small UIAs and an ageing population, and other factors—such as...

SAR443820 did not show clinical benefit and was associated with higher hepatic enzyme increase, indicating that further clinical development of SAR443820 in ALS is not warranted.

Deep learning can identify contrast-enhancing brain tumours from non-contrast MRI. These models show promise as a triage or decision-support aid—for example, flagging studies in which post-contrast en...

In this phase 2 trial, once-daily oral alixorexton provided clinically meaningful improvements at 6 weeks for participants with narcolepsy type 1, including in wakefulness, excessive daytime sleepines...

Plasma p-tau217 concentrations, considered together with APOE genotype, might help stratify risk and estimate the timing of future cognitive impairment in asymptomatic individuals who are at increased...

More than 50 million people live with active epilepsy worldwide, making it one of the most common neurological conditions across the lifespan. More than 80% of this burden falls on poor regions, where...

Intensive blood pressure-lowering treatment after spontaneous intracerebral haemorrhage reduces recurrent stroke, mainly by preventing recurrent haemorrhage, without evidence of excess serious adverse...

Bradycardia due to cardiac conduction abnormalities is prevalent in patients with dementia with Lewy bodies possibly due to autonomic dysfunction and neurodegeneration. Cholinesterase inhibitors remai...

In addition to congenital malformations and neurodevelopmental effects, poor fetal growth should be regarded as an important adverse outcome of prenatal antiseizure medication exposure. Risk varies ac...

Chronic subdural haematoma is associated with increased frailty, comorbidities including dementia, and a higher risk of mortality compared to age-matched controls, with incidence rising as populations...

Prevalence of UIA is increasing, particularly over the past two decades. This increase is only in part explained by improved detection of small UIAs and an ageing population, and other factors—such as...

Explore the current issue of The Lancet Neurology, a monthly journal covering international issues relevant to neurologists worldwide

For decades, a diagnosis of vanishing white matter disease came with no real treatment — so how is an old blood-pressure pill offering hope? In this episode of In Conversation With…The Lancet Neurolog...

In this phase 2 trial, once-daily oral alixorexton provided clinically meaningful improvements at 6 weeks for participants with narcolepsy type 1, including in wakefulness, excessive daytime sleepines...

Explore the current issue of The Lancet Neurology, a monthly journal covering international issues relevant to neurologists worldwide

Neurogenic gastrointestinal, urinary, and sexual symptoms are highly prevalent in people with multiple sclerosis and substantially impair quality of life, daily functioning, and psychosocial well-bein...

Atogepant 60 mg once daily showed better tolerability and efficacy across 24 weeks compared with topiramate. Although both topiramate and atogepant are established as effective oral migraine preventiv...

Bradycardia due to cardiac conduction abnormalities is prevalent in patients with dementia with Lewy bodies possibly due to autonomic dysfunction and neurodegeneration. Cholinesterase inhibitors remai...

In addition to congenital malformations and neurodevelopmental effects, poor fetal growth should be regarded as an important adverse outcome of prenatal antiseizure medication exposure. Risk varies ac...

Intensive blood pressure-lowering treatment after spontaneous intracerebral haemorrhage reduces recurrent stroke, mainly by preventing recurrent haemorrhage, without evidence of excess serious adverse...

Chronic subdural haematoma is associated with increased frailty, comorbidities including dementia, and a higher risk of mortality compared to age-matched controls, with incidence rising as populations...

Guanabenz treatment had an acceptable and manageable safety profile and, after the initial phase, was well tolerated in children with vanishing white matter. Treated patients with disease onset at age...

Read the current issue of EBioMedicine