This study shows that goblet cells physically compress neighboring intestinal cells, creating fractures in cell–cell junctions that weaken epithelial cohesion, increase gut permeability and reveal how...

L’intest

Summary: This Review presents mechanical fracture as a unifying morphogenetic strategy and describes how developmental systems actively exploit mechanical fracture to drive morphogenesis, reproduction...

Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is know...

van der Net et al. show that mechanical interactions with the stromal component collagen I trigger reprogramming of colorectal cancer cells into a fetal-like state, through mechanosensitive integrins ...

Epithelia are specialized tissue barriers that safeguard the organism's internal milieu from the hostile external environment, a function critically dependent on intercellular junctions. In the colon,...

Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...

Cell and tissue movement in development, cancer invasion, and immune response relies on chemical or mechanical guidance cues. In many systems, this...

The authors present a computational framework that leverages mechanical force inference and spatial transcriptomics to enable analyses of the interplay between the transcriptomic and mechanical state.

Bhattacharya et al. delineate chromatin and mRNA dynamics of intestinal secretory differentiation. They demonstrate that goblet and Paneth cells are phenotypic variants of a facile signal-responsive A...

Electric fields guide collective cell migration in developing embryos of Xenopus laevis via a voltage-sensitive phosphatase.

Nature Reviews Molecular Cell Biology, Published online: 29 January 2025; doi:10.1038/s41580-024-00821-0Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of…

Julie Batut ne se contente pas d'exceller dans son domaine. La chercheuse milite activement pour faire de la Science une discipline accessible au plus grand nombre.