iiinova — where your digital self keeps evolving

Reposted by James Nathan

Helena Cocheme @cochemelab.bsky.social · 5h

✨Excited to share our latest paper in Aging Cell!✨ "Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies" Thanks to all the collaborators who made this multi-organism study possible! 💊🪱🪰🐁⏳ #TeamScience #Drosophila #C.elegans #S.pombe #Ageing doi.org/10.1111/acel...

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James Nathan @jamesnathanlab.bsky.social · 14/08/2026

Secure your place at Redox – The Good, The Bad and The Unexpected by the super earlybird deadline of 16 August to save £100! Featuring an international lineup of redox experts, a publishing panel, networking opportunities and more, browse the exciting programme so far 🧪 bit.ly/Redox-26

bit.ly

Redox – The Good, The Bad and The Unexpected

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Reposted by James Nathan

Lorraine Reese @lorraine-reese.bsky.social · 12/08/2026

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Reposted by James Nathan

Ram Chakrabarty @rpc3312.bsky.social · 21/05/2026

Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...

nature.com

Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature

l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...

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Reposted by James Nathan

Helena Cocheme @cochemelab.bsky.social · 15/05/2026

📍 Registration is now open for this #Redox #BiochemicalSociety Meeting! Excellent invited speakers, plus many slots for elevated talks from abstracts, including #ECRs 🫵 🌍 Cambridge, UK 🗓️ 16-18 Nov 2026 ⏳ Super early bird deadline: 16 Aug 2026 🌐 bit.ly/Redox-26 #BiochemEvent @biochemsoc.bsky.social

bit.ly

Redox – The Good, The Bad and The Unexpected

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James Nathan @jamesnathanlab.bsky.social · 15/03/2026

Delighted to share the 'early access' version of our work examining genetic dependencies with VHL loss in ccRCC. Led by James Bertlin. Thanks to our wonderful collaborators Qing Zhang, Annie Speak, Tom Mitchell. Presenting the work today at #AACRkidney26 www.nature.com/articles/s41...

nature.com

VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING - Nature Communications

Biallelic inactivation of the VHL tumour suppressor gene is a hallmark of Clear cell renal cell carcinoma (ccRCC). Here the authors perform genome-wide CRISPR/Cas9 screening to identify that loss of C...

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Reposted by James Nathan

Waggoner Lab @labwaggoner.bsky.social · 13/03/2026

VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING @natcomms.nature.com www.nature.com/articles/s41...

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James Nathan @jamesnathanlab.bsky.social · 29/10/2025

Congratulations Manu, Sarah and Team! Enjoyed contributing to this work www.nature.com/articles/s41...

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James Nathan @jamesnathanlab.bsky.social · 15/10/2025

Excited to share our first bioinformatics contribution! 🎉 Led by Niek Wit in collaboration with the van den Ameele lab @jellevda.bsky.social , we developed DamMapper damid-seq.readthedocs.io/en/latest/, a workflow for DamID-seq analysis, to map SET1B and HIF-1 chromatin occupancy. rdcu.be/eK2TS

rdcu.be

Mapping SET1B chromatin interactions with DamID using DamMapper, a comprehensive Snakemake workflow

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Reposted by James Nathan

Emma Rawlins @labrawlins.bsky.social · 11/10/2025

Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...

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Reposted by James Nathan

The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 22/09/2025

Congrats to #ListerFellow @jamesnathanlab.bsky.social and team on this tremendous paper in Science Advances exploring iron flux and metabolism. "Potentially explaining how some tumors evade antitumoral immunity."

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James Nathan @jamesnathanlab.bsky.social · 18/09/2025

Happy to share latest work from the lab. Led by talented first author @awmartinelli.bsky.social. Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux | Science Advances www.science.org/doi/10.1126/... Congratulations to all the team.

science.org

Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron flux

Genetic screens using endogenous reporters map key modulators of cellular iron, including the transcriptional regulator SETD2.

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Reposted by James Nathan

The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 21/08/2025

"The Lister... spans an incredible breadth of science, giving access to world-leading experts in fields far from my own." @jamesnathanlab.bsky.social James and other #ListerFellows reflect on surprise discoveries and following their curiosity. #ListerPrize 👉 lister-institute.org.uk/curiosity-at...

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James Nathan @jamesnathanlab.bsky.social · 15/07/2025

Delighted to share our latest work on ABHD11 as a novel deglutarylating enzyme, and its role in T cell metabolism @natchembio.nature.com rdcu.be/ewiYZ. Many congratulations to co-first authors Guine Grice, Eleanor Minogue and @hudsonwilco.bsky.social! Great team effort with Randall Johnson's lab.

rdcu.be

Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism

Nature Chemical Biology - Glutarate rewires cell metabolism through conjugation to proteins or fatty acids, but how glutarylation is regulated is unclear. ABHD11 was identified as a...

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Reposted by James Nathan

Isha Jain @ishahjain.bsky.social · 17/02/2025

🚨 New paper alert! 🚨 Check out our latest work on HypoxyStat, a small-molecule therapy that increases oxygen-hemoglobin affinity and provides a practical form of hypoxia therapy. A great collaboration with Maze Therapeutics 🔗 Paper: doi.org/10.1016/j.ce... @cp-cell.bsky.social

doi.org

Redirecting

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Reposted by James Nathan

Christian Frezza @frezzalab.bsky.social · 13/11/2024

People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.

media.tenor.com

a bald man in a blue suit is making a funny face and pointing at something .

ALT: a bald man in a blue suit is making a funny face and pointing at something .

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