iiinova — where your digital self keeps evolving

Reposted by Jelle van den Ameele

Robert Krautz @robertkrautz.bsky.social · 19/05/2026

Absolutely thrilled 💣 to share our preprint 🖨️: "Mapping active cis-regulatory elements from transcription initiation events”. www.biorxiv.org/content/10.6... We introduce nucCAGE and PRIME to identify active cis-regulatory elements (CREs) and disease-associated, non-coding variants.

biorxiv.org

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Reposted by Jelle van den Ameele

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 22/04/2026

Great to bring together 70+ researchers & partners at the LifeArc Centre for Rare Mitochondrial Diseases Annual Meeting in Cambridge last week! From scientific updates and flash talks to patient voice discussions it was a day full of insight and collaboration!

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Reposted by Jelle van den Ameele

Cambridge Fly Club @cambridgeflyclub.bsky.social · 15/04/2026

📢 We are inviting you to the second session of the 2026 @cambridgeflyclub.bsky.social talks.

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Reposted by Jelle van den Ameele

Neha Agrawal @nehaagrawal.bsky.social · 08/04/2026

Fantastic to join the #EdinburghScienceFestival with our lab’s Stitch and Fly workshop! We had a highly interactive, fully booked session discussing our research alongside fruit fly-inspired stitching! Huge thanks to the PhD students in our lab and SBS public engagement team. #Drosophila #Genetics

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Jelle van den Ameele @jellevda.bsky.social · 05/04/2026

Wonderful and honoured to write a perspective with @prudentlab.bsky.social @mrc-mbu.bsky.social on such an intriguing and cool observation of beautiful mitochondrial biology! Amazing work on how pearling allows mitochondrial genome organisation by @jclandoni.bsky.social @sulianamanley.bsky.social!

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Eva Hörmanseder @evahoermanseder.bsky.social · 22/12/2025

We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it: Our work is now out in Nature Communications: 🔗 nature.com/articles/s41467-025-67692-7

nature.com

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James Nathan @jamesnathanlab.bsky.social · 15/10/2025

Excited to share our first bioinformatics contribution! 🎉 Led by Niek Wit in collaboration with the van den Ameele lab @jellevda.bsky.social , we developed DamMapper damid-seq.readthedocs.io/en/latest/, a workflow for DamID-seq analysis, to map SET1B and HIF-1 chromatin occupancy. rdcu.be/eK2TS

rdcu.be

Mapping SET1B chromatin interactions with DamID using DamMapper, a comprehensive Snakemake workflow

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Reposted by Jelle van den Ameele

Emma Rawlins @labrawlins.bsky.social · 11/10/2025

Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...

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Michele Frison @frisophagy.bsky.social · 10/10/2025

Bluesky, I am pleased to present to you the main product of postdoc work, published in @science.org ☝️ As it turns out, the very quality control mechanism that can remove mutant mtDNA copies is the one that maintains high mutant burden, or heteroplasmy levels

High heteroplasmy decreases mitochondrial ubiquitination

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Reposted by Jelle van den Ameele

Cambridge Fly Club @cambridgeflyclub.bsky.social · 23/05/2025

Welcome to the new serie of Cambridge Fly Club meetings. We organise several events every year to foster collaboration and maintain a positive dynamic between Drosophila groups in Cambridge.

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Reposted by Jelle van den Ameele

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 08/05/2025

Thanks to @lilyfoundation.bsky.social for taking these snaps of the centre leads and team members! Together we hope to do great things over the next 5 years of the LifeArc Centre! #mito @ucl-qs-cnmd.bsky.social @taylorlabncl.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social

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Reposted by Jelle van den Ameele

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 07/05/2025

We spent a great afternoon at the House of Lords for the launch of the @lifearc.bsky.social Centre for #Rare #Mitochondrial Diseases, supported by @mdukcharity.bsky.social The event centre hosted staff, dignitaries, patients, MPs & those involved in rare disease policy & research. We even unveiled…

Plaque showing that we are proudly part of the LifeArc Centre for Rare Mitochondrial Diseases, with funding from MDUK

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Reposted by Jelle van den Ameele

Minczuk Lab @mitogene.bsky.social · 12/04/2025

🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

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Reposted by Jelle van den Ameele

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 11/04/2025

2x CRA posts extended until end of April. So you have another chance to work with #mito disease patients as part of the @lifearc.bsky.social centre for #rare #mito diseases! See links below to apply! @eastgenomics.bsky.social @camneuro.bsky.social @cuhnhs.bsky.social

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Reposted by Jelle van den Ameele

Hannah Dickmänken @hannahdckmnkn.bsky.social · 04/04/2025

Our new preprint is out! We optimized our open-source platform, HyDrop (v2), for scATAC sequencing and generated new atlases for the mouse cortex and Drosophila embryo with 607k cells. Now, we can train sequence-to-function models on data generated with HyDrop v2! www.biorxiv.org/content/10.1...

Data collected with the new sequencing platform HyDrop v2 is shown. First, a schematic overview of the bead batches of the microfluidic beads is followed by a tSNE and a barplot showing the costs in comparison to 10x Genomics.
Then, a track of mouse data (cortex) is shown together with nucleotide contribution scores in the FIRE enhancer in microglia. Here, the HyDrop and 10x based models show the same contributions.
On the right, the Drosophila embryo collection is explained; in the paper HyDrop v2 and 10x data are compared to sciATAC data. Then, a nucleotide contribution score is also shown, whereas HyDrop v2 and 10x models show the same contribution, just as in mouse.

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Reposted by Jelle van den Ameele

Seth Cheetham @sethcheetham.bsky.social · 20/03/2025

Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc @laura-leighton.bsky.social found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics. www.biorxiv.org/content/10.1...

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Reposted by Jelle van den Ameele

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 28/02/2025

All the jobs, all in one place!!

Description of 3 job advertisements and the MitoCAMB team

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Reposted by Jelle van den Ameele

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 28/02/2025

📢 We have not 1 but 3 clinical/patient-facing jobs working with #mitoCAMB on the #LifeArc #raredisease centre for #mito diseases. 1x pre/post-doctoral CRA; 1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator Join us! Links below.

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Reposted by Jelle van den Ameele

Robert Krautz @robertkrautz.bsky.social · 26/02/2025

We are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. 💻🔬🧫 Come join me and my lab in beautiful Copenhagen. 🇩🇰 PhD - lnkd.in/dtKz_gnA PostDoc - lnkd.in/dBgn6AcK

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Reposted by Jelle van den Ameele

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 11/02/2025

BBC news article about one of our patients with #neuroferritinopathy on the DefINe clinical trial, funded by #LifeArc. Spread the word about this disease, and also this trial - more participants needed! www.bbc.com/news/article... @ritahorvath.bsky.social @jellevda.bsky.social

bbc.com

Brain drug cure needed for future 'trapped in' generations

Scientists hope to find a cure for a genetic condition linked back to a single Cumbrian family line.

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Jelle van den Ameele @jellevda.bsky.social · 27/01/2025

Congratulations Meghana, Marco and Eva! Great to have played a small part in this beautiful work!

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Reposted by Jelle van den Ameele

Meghana Oak @meghana-oak.bsky.social · 22/01/2025

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here: doi.org/10.1101/2025... 👇 Highlights below

doi.org

H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development

In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...

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