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McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

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Our September webinar featured three early-career researchers working on gut development. Here, we share the talks from Surojit Sural (Columbia University) and Swarnabh Bhattacharya (Dana-Farber Cance...

The intestinal secretory lineage is thought to comprise four distinct cell types derived from one Atoh1+ progenitor, but the mechanisms that distinguish Paneth and goblet cells are unclear. Bhattachar...

Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

Bhattacharya et al. delineate chromatin and mRNA dynamics of intestinal secretory differentiation. They demonstrate that goblet and Paneth cells are phenotypic variants of a facile signal-responsive ATOH1+ cell type and that goblet and Paneth cis-elements and the canonical genes they control interconvert upon modulation of Wnt and BMP signals.

Bhattacharya et al. delineate chromatin and mRNA dynamics of intestinal secretory differentiation. They demonstrate that goblet and Paneth cells are phenotypic variants of a facile signal-responsive A...

This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...

Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...

Nature - Crypt density and recruited enhancers underlie intestinal tumour initiation

The biology of cancer is characterized by an intricate interplay of cells originating not only from the tumor mass, but also its surrounding environment. Different microbial species have been suggest...