Le PDG du Centre national de recherche scientifique, Antoine Petit, a annoncé, le 24 mars, une baisse supplémentaire de 20 millions d’euros sur le budget 2026 de l’institution. Les chercheurs et les d...

Mechanical forces shape the developing heart by controlling cell volume through a Piezo1-driven hydraulic mechanism.

A collection of antigen-stabilizable fluorescent nanobodies becomes fluorescent upon binding to their intracellular targets and enables background-free multicolor imaging and biosensing in living syst...

Scientists have shown that evolution has been using the same genetic ‘cheat sheet’ for over 120 million years, suggesting that life on earth may be more predictable than first imagined.

We present a protocol to measure transcriptional bursting of endogenous human genes that is widely applicable to adherent cells. We describe the steps for nascent RNA fluorescence in situ hybridization (nscRNA-FISH) in a high-throughput imaging format. We then detail the procedures for automated microscopy and analysis to measure bursting behavior of genes in adherent cell lines. The frequency of bursting alleles in a population is used as a readout for bursting behavior. For complete details on...

Neuronal ensembles are groups of neurons with coordinated activity that are related to a specific brain function. Here, we present a protocol to identify and compare neuronal ensembles from neuronal activity data obtained through two-photon microscopy or electrophysiological recordings using a unified graphical user interface (Ensembles Comparison and Recognition [ENCORE]). We describe steps for installing ENCORE, data loading, neuronal ensemble identification, inspecting results, and comparison...

Stable pressure gradients can arise in cells from the combination of actomyosin-generated cortical tension, cytoplasmic poroelasticity, and water flows across the membrane.

A novel pipeline for analyzing longitudinal two-photon microscopy data of cerebrovasculature in mice interrogates the vasculature network before and after optogenetic stimulation, revealing new insights...

Pérez-Verdugo et al. show that hindbrain neuropore closure is driven by surface ectoderm actomyosin purse-string tension and active migration. These forces create reproducible patterns of cell elongat...

Ethel Browne Harvey et Hilde Pröscholdt Mangold ont mené des recherches pionnières en embryologie, Ida Henrietta Hyde a contribué à la mise au point des premi

Marthe Gautier est à l’origine de la découverte du chromosome surnuméraire de la trisomie 21, anomalie génétique qui touche 50 000 personnes en France. À l’occasion de la Journée mondiale de la trisom...

As funding for science tightens across the United States, attention has turned to pressures faced by universities and biomedical research institutions. An often overlooked part of the nation’s science...