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Debraj Ghose

@debrajghose.bsky.social
985 followers 3.8K following 27 posts

I study how lymphocytes self-organize into multicellular structures. Also interested in how cells sense and respond to chemical gradients. Currently at UCSF. Previously at Harvard and Duke.

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Reposted by Debraj Ghose
Dr. Allyson Sgro @allysonsgro.bsky.social · 02/01/2026
Thrilled that the lab's first @hhmijanelia.bsky.social project is up on bioRxiv! Story behind the story to follow. www.biorxiv.org/content/10.6...
biorxiv.org
Memory from variability: Heritable short-term cellular memory emerges from stochastic biochemical reaction networks
Cells exhibit a mysterious form of selective heritable short-term memory, influencing outcomes as diverse as cell fate decisions in embryos and environmental responses in cancer cells and bacteria. He...
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Dr. Allyson Sgro @allysonsgro.bsky.social · 08/12/2025
Sit with this for a moment.
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Sophien Kamoun @kamounlab.bsky.social · 03/12/2025
I just published: ERC-Plus: jackpot science or missed chance to fix academia? My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building. medium.com/p/erc-plus-j...
medium.com
ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re…
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Ahmed El Hady @zamakany.bsky.social · 11/11/2025
It was a pleasure to co-organize with @allysonsgro.bsky.social Junior Scientist Workshop on Theoretical Biophysics at @hhmijanelia.bsky.social. We had great lectures and tutorials on theoretical approaches used to understand biological phenomena. Can't wait for the 2026 iteration, stay tuned.
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Rasmus Jensen @rasmusjensen.bsky.social · 19/11/2025
Tired of knowing what you are looking for in your tomograms? Why not try bluesky-less Frosina's new self-supervised algorithm for semantic segmentation and particle picking for #teamtomo (includes a new denoiser without the need for odd/even tomos) Code is on GitHub if you want to try it out
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The Daum Lab @daumlab.bsky.social · 24/11/2025
An exciting PhD opportunity is available in my lab! More info about our group and research can be found here: bdaum2.wixsite.com/daumlab Application deadline: 8th Jan 2026. Apply here: www.exeter.ac.uk/study/pg-res... If you are interested, get in touch! #ArchaeaSky #CryoEM #TeamTomo
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Xiangyi Ding @xiangyiding.bsky.social · 10/09/2025
Thrilled to share that a big piece of my thesis here in the Starr–Luxton is now out in Science Advances! We discovered that the cytoplasm of living animal tissues is extremely crowded and constrained, maintained by ribosomes and the giant KASH protein ANC-1. www.science.org/doi/10.1126/...
science.org
Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo
Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.
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Debraj Ghose @debrajghose.bsky.social · 18/11/2025
1/5: New preprint: Cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1... Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.
biorxiv.org
Cytokines control the physical state of immune tissue
Unlike most solid-like tissues, immune tissue is protean and reconfigurable—its component cells can patrol vast territories, find rare cellular partners, and dynamically self-organize into functional ...
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Dagmar Iber & CoBi @iberd.bsky.social · 30/07/2025
How can cells self-organize rapidly into complex patterns during development? Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM). Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025... 👇Thread 🧵(1/11)
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Maik Bischoff @maikbischoff.bsky.social · 18/07/2025
Such an honor to be featured by @focalplane.bsky.social , especially on my favorite day of the week: #FluorescenceFriday! 🔬 Below for reference, a picture of the full hydei testis with the musculature stained (depth-coded) taken together with @saraheclark.bsky.social #cellbio #devbio #microscopy
The full testis of Drosophila hydei with muscles stained with phalloidin. A close up of the same muscles was featured by FocalPlane.
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Emma Scales @emmascales.bsky.social · 19/07/2025
Happy #FluorescenceFriday !!! Pt 2: fungal hyphae challenged with various oxidative stressors; nucleic acids - yellow, ROS - magenta feat. bubbles induced by H2O2 from earlier imaging experiments when I had no idea what I was doing :)
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Adam Braithwaite @braithwaiteat.bsky.social · 03/07/2025
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
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Maik Bischoff @maikbischoff.bsky.social · 18/06/2025
FINALLY out in #Science Advances! 🎉 3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author! It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀 www.science.org/doi/10.1126/... #DevBio #CellBio #Microscopy
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Debraj Ghose @debrajghose.bsky.social · 16/06/2025
3D printed microscopy we could perhaps try in the lab onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
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Scabbage @voxygen.dev · 16/05/2025
#GLSL #Shaders
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Julian Gargiulo @nano-juli.bsky.social · 26/02/2025
HIGH-RESOLUTION IN VIVO BRAIN IMAGING OF DROSOPHILA 🪰 New Preprint by Tassara et al.! www.biorxiv.org/content/10.1... #FluorescenceMonday #SnoutClub 1/6
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Amy Engevik @amyengevik.bsky.social · 02/06/2025
A perfectly round liver organoid stained for mitochondria (yellowish/green), e-cadherin in blue and nuclei in pink for #MicroscopyMonday
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Vincent Hickl @hicklvincent.bsky.social · 11/04/2025
Excited to share our latest paper in PLOS Comp Bio, describing how accurate, multi-species segmentation models for bacteria can be created quickly and easily using image-to-image translation. 🧪⚛️ #biophysics #imageanalysis #microscopy #AI dx.doi.org/10.1371/jour...
dx.doi.org
Segmentation of dense and multi-species bacterial colonies using models trained on synthetic microscopy images
Author summary Bacteria organize themselves on surfaces in ways that influence the spread of infections, but studying these behaviors is difficult, especially when multiple species are involved or the...
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Dominik Robak @dominikrobak.bsky.social · 15/04/2025
Bonus: ran a quick color variation test — because it's always worth playing with presentation. Color isn’t just style — it shapes what you see. #MicroscopyCommunity #ScientificVisualization #Biophysics
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Journal of Cell Biology @jcb.org · 24/04/2025
#Microtubule-driven cell shape changes and #actomyosin flow synergize to position the #centrosome, say Alexandre Schaeffer, Manuel Théry (@manuelthery.bsky.social ) and colleagues: rupress.org/jcb/article/... @lblanchoin.bsky.social @gelinmatthieu.bsky.social #Biophysics #Cytoskeleton
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Maik Bischoff @maikbischoff.bsky.social · 08/05/2025
My #FlyWeek contribution: The Variety of Testis Shapes in Pomace Fly Species Aren't they beatiful?🌈🪰🔬 An old-school sci-poster meets modern confocal imaging! #Drosophila testis diversity fascinated even Curt Stern (yes, the human genetics textbook guy!) back in the 1930s. #microscopy #insects
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eric lai @lucksmith.bsky.social · 08/05/2025
indeed, i begin my grad lecture on RNAi/miRNAs by discussing petunias. and mentioning while none of our students will do a plant phd (no faculty), they can learn A LOT by occasionally reading plant literature (think epigenetics, small RNAs, developmental biology, etc etc). also, consider the worm!
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Rebecca Ann Jones @rebannjones.bsky.social · 06/05/2025
What governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! @narjournal.bsky.social academic.oup.com/nar/article/...
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Jupiter Algorta @jupiteralgorta.bsky.social · 06/05/2025
If you're curious about how cells make decisions in complex environments, and how mathematical models can capture such behaviour, our preprint is now live! Check it out here: www.biorxiv.org/content/10.1...
biorxiv.org
Investigating Local Negative Feedback of Rac Activity by Mathematical Models and Cell Motility Simulations
For polarization and directed migration, cells use a combination of local positive feedback and long-range inhibition. We have previously used mathematical models to show the ability of this core…
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Debraj Ghose @debrajghose.bsky.social · 05/05/2025
We found that cells use emergent collective memory—arising from simple chemical reactions—to outperform physical limits of detecting chemical gradients. Curious how? 1/n 8 min talk: www.youtube.com/watch?v=A7XH... bioRxiv: www.biorxiv.org/content/10.1... #biophysics #cellbiology
youtube.com
Local collective memory from ratiometric signaling outperforms cellular gradient sensing limits
YouTube video by Debraj Shubham Ghose
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Reto Fiolka @retof.bsky.social · 11/12/2024
U2OS labeled with OMP25-GFP, an outer membrane marker for mitochondria. Left shows a zoom-in on the dimmer cell. Imaged by OPM (oblique plane microscope). #Microscopy
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Rachael Ott @rachaelott.bsky.social · 17/01/2025
For #FluorescenceFriday, tau (blue) and long loops of neurofilament proteins are shown in a primary hippocampal neuron 🔬 #Neuroscience #Microscopy
Tau (blue) and neurofilament (fire) are shown in a primary hippocampal neuron.
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Danielle Beckman @daniellebeckman.bsky.social · 18/01/2025
It's #FluorescenceFriday! Here goes one image showing pathological Tau🟢 spreading in the monkey hippocampus. Neurons in 🟢 are dying, and healthy neurons in 🟣. Pathology spreads in a prion-like manner in this novel monkey model of Alzheimer we developed. How do we know that?
Microscopy photo showing neurons accumulating phospho Tau in green, and healthy neurons (NeuN) in purple.
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Eric Topol @erictopol.bsky.social · 15/01/2025
Could inhaling Xenon be used someday to prevent or treat Alzheimer's disease? An intriguing experimental model study shows its effect on modulating brain microglia and reducing inflammation www.science.org/doi/10.1126/...
science.org
Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy
Xenon inhalation modulates microglial responses in mice and is a potential therapeutic agent for treating Alzheimer’s disease.
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Rod Rahimi @rodrahimi.bsky.social · 18/01/2025
Cool story on an IL-33-ILC2-myeloid cell circuit that promotes tertiary lymphoid structure development in tumors #ImmunoSky 🧪⚕️ "our findings highlight IL-33 as a candidate inflammatory TLS initiator, and ILC2s as a candidate inducer, of such a pathway."
nature.com
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer - Nature
IL-33 induces tertiary lymphoid structures.
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Debraj Ghose @debrajghose.bsky.social · 01/01/2025
Self-regulating insulin, very cool! www.nature.com/articles/s41...
nature.com
Glucose-sensitive insulin with attenuation of hypoglycaemia - Nature
NNC2215 is an insulin conjugate that can reversibly adjust its bioactivity in response to a diabetes-relevant glucose range in vivo.
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epithelial mechanics fan club @epimechfc.bsky.social · 31/12/2024
Ranft, J., Basan, M., ..., Prost, J., & Jülicher, F. (2010). Fluidization of tissues by cell division and apoptosis. Proceedings of the National Academy of Sciences of the United States of America, 107(49), 20863–20868. #EpithelialMechanics www.pnas.org/doi/full/10.1073/pnas.…
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Wallace Marshall @wallaceucsf.bsky.social · 31/12/2024
this is so cool!!!!
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c0nc0rdance @c0nc0rdance.bsky.social · 25/12/2024
"Ants solving a geometric problem and it's amazing." This is a great example of 'emergent phenomenon': - None of the ants understand the problem they're solving. - None of them can see the whole shape. - A series of small decisions or rules add up to something with a new layer of complexity.
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Stephane Vassilopoulos @stefvass.bsky.social · 21/12/2024
Dynamic duo at the cell's edge: Caveolae and the actin cytoskeleton work together to sense and respond to mechanical stress. Caveolae buffer tension, while actin provides structure and force. Ultimate biomechanics team. #CellBiology #Mechanotransduction
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Alex Hughes Lab @hugheslabpenn.bsky.social · 20/12/2024
Happy holidays from the Hughes lab ✨ #fluorescencefriday
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Ute Hentschel @utehentschel.bsky.social · 20/12/2024
Oh wow! E.coli expressing biosilica from sponges.
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Mathieu Preußner @mathpreu.bsky.social · 20/12/2024
🔬My first try on #FluorescenceFriday Nice detail of a tissue-cleared kidney from neonatal mice. -GFP is expressed in podocytes and pericytes. -CD31 antibody highlights the branched blood vessels and glomeruli in red
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Science Magazine @science.org · 20/12/2024
Between 800,000 and 900,000 years ago, the population of human ancestors crashed, a 2023 Science study finds. The results suggest there were only ~1280 breeding individuals during the transition between the early and middle Pleistocene. scim.ag/401GZSU #ScienceMagArchives
scim.ag
Genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition
A severe bottleneck that brought human ancestors close to extinction occurred between about 930 and 813 thousand years ago.
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Andrew G. York @andrewgyork.bsky.social · 22/11/2024
MagLOV! MagLOV is a fluorescent protein you can "turn off" with a handheld magnet, engineered by @mariaingaramo.bsky.social. We think/hope we can use it to turn arbitrary proteins (including drugs!) on and off in opaque creatures (including humans!). bsky.app/profile/addg...
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Vaughn Cooper @vscooper.micropopbio.org · 12/12/2024
I’m proud to join more than 30 colleagues today in sharing our analysis of potential risks from “mirror life”. We summarize our findings in a @science.org article, and in greater detail in a 300pg technical report: Article: www.science.org/doi/10.1126/... Report: purl.stanford.edu/cv716pj4036
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Torsten Wittmann @handle.invalid · 06/12/2024
Highlighting our recent paper on how we think doublecortin (green) contributes to growth cone biomechanics in developing neurons for #FluorescenceFriday www.cell.com/current-biol...
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Danielle Beckman @daniellebeckman.bsky.social · 06/12/2024
It's #FluorescenceFriday and this will always be one of my favorite photos I took from the hippocampus, a small, complex part of the brain that plays a key role in learning and memory. This region is involved in all my projects, plays a key role in Alzheimer and also can be affected by #NeuroCovid.
A confocal micrograph showing the hippocampus of rhesus macaque. Neurons are shown in yellow (NeuN marker), and astrocytes are shown in blue (GFAP marker)
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Debraj Ghose @debrajghose.bsky.social · 07/12/2024
@itaiyanai.bsky.social I completely agree! However, I've noticed people sometimes misinterpret the advice to avoid rigid hypotheses and assume they don't need to have questions while generating or analyzing data
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Johan Duchêne @johanduchene.bsky.social · 06/12/2024
Like a river. Blood vessels. #fluorescencefriday
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Lydia Daboussi @daboussi.bsky.social · 07/12/2024
Late addition for #fluorescencefriday Cultured neurons (red/yellow) interacting with glia (green). Imaged by the talented undergraduate researcher Grace Haroun.
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Pablo J. Sáez @pjsaez.bsky.social · 06/12/2024
As promised, here a fast acquisition of a migrating cell videoed under a microscopy, look those membrane dynamics @ the leading edge ! Bonus: nuclear deformation once the cell rear snaps. (Fluo nucleus, for the #fluorescencefriday) @focalplane.bsky.social @cellcommlab.bsky.social #CellMigration 🧪🔬
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