iiinova — where your digital self keeps evolving

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David M. Versluis @davidversluis.bsky.social · 07/10/2026

I have a new paper out: Communication through autoattractants can enhance and limit collective migration of immune cells journals.plos.org/ploscompbiol... We show how complex interactions emerge around a secreted attractant, and you can play with the model online: chemotaxis.org/autoattracta...

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Dr. Allyson Sgro @allysonsgro.bsky.social · 08/12/2025

Sit with this for a moment.

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Sophien Kamoun @kamounlab.bsky.social · 03/12/2025

I just published: ERC-Plus: jackpot science or missed chance to fix academia? My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building. medium.com/p/erc-plus-j...

medium.com

ERC-Plus: jackpot science or missed chance to fix academia?

My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re…

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Debraj Ghose @debrajghose.bsky.social · 28/11/2025

When stained and unstained human B cell aggregates are placed next to each other, they coalesce, internally mix, and undergo surface tension-like rounding. www.biorxiv.org/content/10.1... youtu.be/QAk2ayoVF0M #FuorescenceFriday

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Ahmed El Hady @zamakany.bsky.social · 11/11/2025

It was a pleasure to co-organize with @allysonsgro.bsky.social Junior Scientist Workshop on Theoretical Biophysics at @hhmijanelia.bsky.social. We had great lectures and tutorials on theoretical approaches used to understand biological phenomena. Can't wait for the 2026 iteration, stay tuned.

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Rasmus Jensen @rasmusjensen.bsky.social · 19/11/2025

Tired of knowing what you are looking for in your tomograms? Why not try bluesky-less Frosina's new self-supervised algorithm for semantic segmentation and particle picking for #teamtomo (includes a new denoiser without the need for odd/even tomos) Code is on GitHub if you want to try it out

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The Daum Lab @daumlab.bsky.social · 24/11/2025

An exciting PhD opportunity is available in my lab! More info about our group and research can be found here: bdaum2.wixsite.com/daumlab Application deadline: 8th Jan 2026. Apply here: www.exeter.ac.uk/study/pg-res... If you are interested, get in touch! #ArchaeaSky #CryoEM #TeamTomo

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Debraj Ghose @debrajghose.bsky.social · 26/11/2025

This amazing! Congratulations!!!

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Xiangyi Ding @xiangyiding.bsky.social · 10/09/2025

Thrilled to share that a big piece of my thesis here in the Starr–Luxton is now out in Science Advances! We discovered that the cytoplasm of living animal tissues is extremely crowded and constrained, maintained by ribosomes and the giant KASH protein ANC-1. www.science.org/doi/10.1126/...

science.org

Giant KASH proteins and ribosomes establish distinct cytoplasmic biophysical properties in vivo

Living tissues maintain unique intracellular biophysical properties under the control of cytoplasmic constraints and crowding.

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Debraj Ghose @debrajghose.bsky.social · 19/11/2025

Immune tissue behaves as shapeshifting active living matter as it fights intruders. Using liquid-like multicellular B cell droplets, we show that cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1... youtu.be/QAk2ayoVF0M #biophysics #immunology #activematter

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Debraj Ghose @debrajghose.bsky.social · 18/11/2025

5/5 I am excited to extend these insights to frame immune function as an emergent property of interacting, multicellular active matter. Many thanks to Tom Ferrante, Don Ingber and his lab, Sloan Foundation's Matter-to-Life program, and the Wyss Institute at Harvard University.

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Debraj Ghose @debrajghose.bsky.social · 18/11/2025

4/5 We discovered that the same cytokines driving B cell fate also modulate the material properties of BLOMBs. This suggests that cytokines control the physical state of immune tissue. youtu.be/ItWdDz2i8io

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Debraj Ghose @debrajghose.bsky.social · 18/11/2025

3/5 To identify the biological 'control knobs' of immune tissue, we utilized CD40L-induced B cell aggregates as a model system. We demonstrated that these structures function as liquid droplets, terming them B-Lymphocyte Organized Multicellular Blobs (BLOMBs). youtu.be/QAk2ayoVF0M

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YouTube video by Debraj Shubham Ghose

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Debraj Ghose @debrajghose.bsky.social · 18/11/2025

2/5 Our computational model predicted that the efficiency of antibody evolution is governed by the tissue's physical state. This motivated our search for chemical signals capable of tuning this material property.

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Debraj Ghose @debrajghose.bsky.social · 18/11/2025

1/5: New preprint: Cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1... Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.

biorxiv.org

Cytokines control the physical state of immune tissue

Unlike most solid-like tissues, immune tissue is protean and reconfigurable—its component cells can patrol vast territories, find rare cellular partners, and dynamically self-organize into functional ...

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Debraj Ghose @debrajghose.bsky.social · 18/11/2025

3/5: To search for these control knobs, we studied homotypic aggregates formed by primary human B cells stimulated with GC factor CD40L as a model. We showed they behave like liquid droplets and thus called them B Lymphocytes Organized as Multicellular Blo(m)bs (BLOMBs). youtu.be/QAk2ayoVF0M

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Dagmar Iber & CoBi @iberd.bsky.social · 30/07/2025

How can cells self-organize rapidly into complex patterns during development? Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM). Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025... 👇Thread 🧵(1/11)

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Maik Bischoff @maikbischoff.bsky.social · 18/07/2025

Such an honor to be featured by @focalplane.bsky.social , especially on my favorite day of the week: #FluorescenceFriday! 🔬 Below for reference, a picture of the full hydei testis with the musculature stained (depth-coded) taken together with @saraheclark.bsky.social #cellbio #devbio #microscopy

The full testis of Drosophila hydei with muscles stained with phalloidin. A close up of the same muscles was featured by FocalPlane.

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Emma Scales @emmascales.bsky.social · 19/07/2025

Happy #FluorescenceFriday !!! Pt 2: fungal hyphae challenged with various oxidative stressors; nucleic acids - yellow, ROS - magenta feat. bubbles induced by H2O2 from earlier imaging experiments when I had no idea what I was doing :)

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Adam Braithwaite @braithwaiteat.bsky.social · 03/07/2025

Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...

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Maik Bischoff @maikbischoff.bsky.social · 18/06/2025

FINALLY out in #Science Advances! 🎉 3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author! It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀 www.science.org/doi/10.1126/... #DevBio #CellBio #Microscopy

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Debraj Ghose @debrajghose.bsky.social · 16/06/2025

3D printed microscopy we could perhaps try in the lab onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com

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Julian Gargiulo @nano-juli.bsky.social · 26/02/2025

HIGH-RESOLUTION IN VIVO BRAIN IMAGING OF DROSOPHILA 🪰 New Preprint by Tassara et al.! www.biorxiv.org/content/10.1... #FluorescenceMonday #SnoutClub 1/6

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Amy Engevik @amyengevik.bsky.social · 02/06/2025

A perfectly round liver organoid stained for mitochondria (yellowish/green), e-cadherin in blue and nuclei in pink for #MicroscopyMonday

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Dominik Robak @dominikrobak.bsky.social · 15/04/2025

Bonus: ran a quick color variation test — because it's always worth playing with presentation. Color isn’t just style — it shapes what you see. #MicroscopyCommunity #ScientificVisualization #Biophysics

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Journal of Cell Biology @jcb.org · 24/04/2025

#Microtubule-driven cell shape changes and #actomyosin flow synergize to position the #centrosome, say Alexandre Schaeffer, Manuel Théry (@manuelthery.bsky.social ) and colleagues: rupress.org/jcb/article/... @lblanchoin.bsky.social @gelinmatthieu.bsky.social #Biophysics #Cytoskeleton

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Maik Bischoff @maikbischoff.bsky.social · 08/05/2025

My #FlyWeek contribution: The Variety of Testis Shapes in Pomace Fly Species Aren't they beatiful?🌈🪰🔬 An old-school sci-poster meets modern confocal imaging! #Drosophila testis diversity fascinated even Curt Stern (yes, the human genetics textbook guy!) back in the 1930s. #microscopy #insects

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eric lai @lucksmith.bsky.social · 08/05/2025

indeed, i begin my grad lecture on RNAi/miRNAs by discussing petunias. and mentioning while none of our students will do a plant phd (no faculty), they can learn A LOT by occasionally reading plant literature (think epigenetics, small RNAs, developmental biology, etc etc). also, consider the worm!

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Rebecca Ann Jones @rebannjones.bsky.social · 06/05/2025

What governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! @narjournal.bsky.social academic.oup.com/nar/article/...

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Debraj Ghose @debrajghose.bsky.social · 05/05/2025

Manuscript: www.biorxiv.org/content/10.1... Feedback welcome! Talk: www.youtube.com/watch?v=A7XH... Had a ton of fun working on this with James Nolen and Daniel Lew! Super glad Kathy Guan and Timothy Elston joined us on our adventure! Grateful to NIH and Sloan Foundation for their support! n/n

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Local collective memory from ratiometric signaling outperforms cellular gradient sensing limits

YouTube video by Debraj Shubham Ghose

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Debraj Ghose @debrajghose.bsky.social · 05/05/2025

This strategy could underly fertilization, immune responses, embryo patterning—or allow us to build gradient-sensing microrobots for targeted drug delivery. 8/n

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Debraj Ghose @debrajghose.bsky.social · 05/05/2025

This local memory allows cells to average receptor signals and outperform instantaneous cellular gradient sensing limits. — Left: classical sensing drifts. — Right: ratiometric model stays locked on target. 7/n

Schematic showing that gradient estimates by ratiometric sensing outperform estimates by classical sensing.

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Debraj Ghose @debrajghose.bsky.social · 05/05/2025

We find that the ratiometric readout, which is enabled by a population of diffusing G‑proteins, generates a rolling local collective memory of past receptor states. 6/n

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Debraj Ghose @debrajghose.bsky.social · 05/05/2025

Surprisingly, our simulations show that the ratiometric sensing strategy can outperform instantaneous physical limits of gradient detection. How??? 5/n www.youtube.com/watch?v=B3Dg...

youtube.com

Ratiometric NG 2500 NR 375 Dm 002 Pher 8 4 1

YouTube video by Debraj Shubham Ghose

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Debraj Ghose @debrajghose.bsky.social · 05/05/2025

But cells also pay attention to the “quiet.” By comparing bound (ON) and unbound (OFF) receptors, they build a ratiometric readout. 4/n

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Debraj Ghose @debrajghose.bsky.social · 05/05/2025

Classic view: focus only on the “ON” beeps—molecules binding to receptors. Useful, but half the story. 3/n

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Debraj Ghose @debrajghose.bsky.social · 05/05/2025

Cells often infer faint signals from noisy and complex chemical landscapes—like picking out a whisper in a packed stadium. One wrong move could derail development or immunity. 2/n

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Debraj Ghose @debrajghose.bsky.social · 05/05/2025

We found that cells use emergent collective memory—arising from simple chemical reactions—to outperform physical limits of detecting chemical gradients. Curious how? 1/n 8 min talk: www.youtube.com/watch?v=A7XH... bioRxiv: www.biorxiv.org/content/10.1... #biophysics #cellbiology

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Local collective memory from ratiometric signaling outperforms cellular gradient sensing limits

YouTube video by Debraj Shubham Ghose

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Reto Fiolka @retof.bsky.social · 11/12/2024

U2OS labeled with OMP25-GFP, an outer membrane marker for mitochondria. Left shows a zoom-in on the dimmer cell. Imaged by OPM (oblique plane microscope). #Microscopy

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Rachael Ott @rachaelott.bsky.social · 17/01/2025

For #FluorescenceFriday, tau (blue) and long loops of neurofilament proteins are shown in a primary hippocampal neuron 🔬 #Neuroscience #Microscopy

Tau (blue) and neurofilament (fire) are shown in a primary hippocampal neuron.

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