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York Biomedical Research Institute

@ybri-uoy.bsky.social
157 followers 134 following 36 posts

Our mission at the York Biomedical Research Institute (YBRI) is to advance discoveries in biomedical science, to inspire, train, and mentor the next generation of biomedical researchers.

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York Biomedical Research Institute @ybri-uoy.bsky.social · 04/02/2026
@fariatrypslab.bsky.social in a major collaborative effort with researchers from Imperial College, Oxford, Oxford Brookes, and Edinburgh, has identified a novel factor, ESBX, as the key coordinator between the activation and repression of surface antigen genes in trypanosomes.
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Centre for Blood Research @cbr-uoy.bsky.social · 04/02/2026
Great to see York Press spotlight the £2.5m awarded last year to CBR members for blood cancer research - continued recognition of work driving better understanding and future treatments #BloodCancerResearch #CBR #YorkScience #ResearchImpact www.yorkpress.co.uk/news/2582263...
yorkpress.co.uk
£2.5m boost for University of York to advance pioneering blood cancer research
University of York researchers have received a £2.5 million boost from Cancer Research UK to advance pioneering work into blood cancers.
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uofytechs.bsky.social @uofytechs.bsky.social · 28/01/2026
#job Research Technician with Faria & Mottram groups within @biologyatyork.bsky.social @ybri-uoy.bsky.social investigating the interplay between genome organisation, nuclear architecture & gene expression regulation in Leishmania. Apply by: 23/02/2026 jobs.york.ac.uk/vacancy/tech...
jobs.york.ac.uk
Jobs - The University of York
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Faria Tryps Lab @fariatrypslab.bsky.social · 28/01/2026
We’re hiring a PDRA and a technician! If you’re passionate about #parasites #genomes #condensates then this project is for you! Help us decode the role of nuclear architecture in gene expression regulation in #Leishmania alongside the @mottramlab.bsky.social @york.ac.uk @ybri-uoy.bsky.social
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York Biomedical Research Institute @ybri-uoy.bsky.social · 22/01/2026
📢 2 funded PhD positions at the University of York IndiBrain MSCA Doctoral Network, ERC-funded Central vision loss: linking neural + psychosocial factors to predict outcomes - with Dr Heidi Baseler & Dr Holly Brown Stereo vision differences + brain connectivity - with Prof Tony Morland
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Open Research at York @uoyopenres.bsky.social · 05/12/2025
"We think this research is incredibly exciting because it suggests that bladder cancer might be preventable" #openaccess paper in @aaas.org Science Advances - see thread below from @drsimonbaker.bsky.social @biologyatyork.bsky.social @ybri-uoy.bsky.social 🔓 📄
york.ac.uk
Bladder cancer may be caused by the body’s response to a common virus, new research suggests
Bladder cancer might be caused by our cell’s response to a common virus which infects nearly everyone in childhood, according to new research led by scientists at the University of York.
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York Biomedical Research Institute @ybri-uoy.bsky.social · 14/11/2025
Delighted to have Prof Jenna Gregory as today's Biomedical Science seminar speaker from @uniofaberdeen.bsky.social Jenna presented her work on improving translation in neurodegenerative diseases Hosted by Prof Stephen Smith
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York Biomedical Research Institute @ybri-uoy.bsky.social · 07/11/2025
Excited to have Dr Adrian Najer as today's Biomedical Science seminar speaker from @imperialcollegeldn.bsky.social Adrian presented his work on nanomedicines and nanodiagnostics for parasites, viruses, and bacteria Hosted by Dr Stuart Higgins
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York Biomedical Research Institute @ybri-uoy.bsky.social · 03/11/2025
Exciting news! 🎉 We'd like to welcome Professor Ian Hitchcock as our new Director. With a passion for innovation and collaboration, @ian-hitchcock.bsky.social will lead us into an inspiring new chapter of research excellence
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York Biomedical Research Institute @ybri-uoy.bsky.social · 31/10/2025
Congrats to @joanarcf.bsky.social @biologyatyork.bsky.social who has been awarded a BBSRC responsive mode grant, with @mottramlab.bsky.social as a co-I & collaborators @ipmontevideo.bsky.social @warwickuni.bsky.social
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William (Bill) Grey @billgrey.bsky.social · 31/10/2025
🚨 We have 3 fully funded PhD studentships open! Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology 📍Start Oct 2026 | 💡Apply via MRC & BBSRC 👇Details in thread 👇
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York Biomedical Research Institute @ybri-uoy.bsky.social · 31/10/2025
Thrilled to have @ewanbirney.bsky.social as today's BMS seminar speaker & as a keynote in the @biologyatyork.bsky.social Postdoc Symposium Ewan presented his work on "Genomics, Imaging and AI: three technologies changing research and healthcare" Hosted by Prof Gavin Wright
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York Biomedical Research Institute @ybri-uoy.bsky.social · 31/10/2025
Discovery Medicine North (DiMeN) PhD projects are now open for applications! Are you looking for exceptional research training and support, access to outstanding facilities and expertise, and enhanced funding and training to support career development and research excellence?
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York Biomedical Research Institute @ybri-uoy.bsky.social · 10/10/2025
Excited to have @sankarinagarajan.bsky.social @mcf-uom.bsky.social as our Biomedical Science seminar speaker today, hosted by @andrewholding.bsky.social Sankari presented her work on the role of transcription factors in mediating the progression to drug resistance and metastasis in breast cancer
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York Biomedical Research Institute @ybri-uoy.bsky.social · 03/10/2025
Excited to have @alainkohlvirology.bsky.social as this weeks Biomedical Science seminar speaker, talking about his work on antiviral RNAi in mosquitoes. Hosted by Dr Natalie Prow.
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Steve Quinn @steve-quinn-lab.bsky.social · 02/10/2025
We are delighted that our latest @york.ac.uk & @ybri-uoy.bsky.social work showcasing our photonic biosensor for Alzheimer's disease blood biomarkers has been published in @optica.org! 👇 opg.optica.org/optica/fullt... Thanks to @alzheimerssoc.bsky.social & @alzheimersresearchuk.org for support!
opg.optica.org
Optica Publishing Group
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Steve Quinn @steve-quinn-lab.bsky.social · 29/09/2025
New preprint! 🚨 I'm delighted to share our latest @york.ac.uk & @ybri-uoy.bsky.social pre-print: "Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching." Congratulations to Claudia from the team on her first manuscript! 👇👇 www.biorxiv.org/content/10.1...
biorxiv.org
Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching
Detergent-induced membrane solubilization is important for several biotechnological applications including membrane protein isolation, cell lysis and virus inactivation. The thermodynamic details of t...
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York Biomedical Research Institute @ybri-uoy.bsky.social · 26/09/2025
Pleased to have @elkslab.bsky.social kicking off the 2025-26 series of our Biomedical Seminars, hosted by @noemiehamilton.bsky.social Phil presented his work on using zebrafish models to study the roles of HIF in host response to infection
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Centre for Blood Research @cbr-uoy.bsky.social · 17/09/2025
Research conducted by our Director @ian-hitchcock.bsky.social's collaborators in Oxford has found that platelets could help make cancer-detecting blood tests much more effective Read more about the study on ‪@cancerresearchuk.org‬ website news.cancerresearchuk.org/2025/08/14/p...
news.cancerresearchuk.org
The "humble" blood cells that could expose cancer's secrets - Cancer Research UK - Cancer News
Our scientists have discovered that platelets are swelling with information which could help us detect cancers earlier.
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Ines Hahn @exdrososcientia.bsky.social · 12/09/2025
We're kicking off the third #NeuroBioUK - an exciting day full of neuronal cell biology ahead! Massive thank for @bscb-official.bsky.social support and a shout out to our industry sponsors!
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Dimitris Lagos @dimitrislagos.bsky.social · 28/08/2025
What’s the difference between female and male Th cells? We have a new paper on this! The mighty Malat1 controls Th2 differentiation in female but not male cells. Work by Mags Gwynne and Katie West ‪@jimmunol.bsky.social‬ doi.org/10.1093/jimm... @york.ac.uk‬, @ybri-uoy.bsky.social‬, ‪@hyms.ac.uk‬
doi.org
Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2
Abstract. Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is
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Gavin Thomas (he/him) @gavinhthomas.bsky.social · 02/09/2025
Delighted with our new paper on a novel itaconate transporter in the human pathogen Pseudomonas aeruginosa, led by Javeria and Reyme. @ybri-uoy.bsky.social @javeriamehboob.bsky.social @bethkw.bsky.social A duplicated transporter on its way to itaconate selectivity portlandpress.com/biochemj/art...
portlandpress.com
Itaconate utilisation by the human pathogen Pseudomonas aeruginosa requires uptake via the IctPQM TRAP transporter
Pseudomonas aeruginosa PA01 is one of the major causes of disease persistence and mortality in patients with lung pathologies, relying on various host metabolites as carbon and energy sources for grow...
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Gavin Thomas (he/him) @gavinhthomas.bsky.social · 12/08/2025
First paper from Orlagh Anderson PhD project is out. She found a chromid is a distinct & unique feature of Clostridium butyricum. More to come on the virulence related genes.. @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Comparative genomics of Clostridium butyricum reveals a conserved genome architecture and novel virulence-related gene clusters
Bacteria from the species Clostridium butyricum encompass a diverse range of phenotypes. While some strains are used as probiotics, others have been isolated from cases of botulism and necrotizing ent...
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Faria Tryps Lab @fariatrypslab.bsky.social · 11/08/2025
How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social ! @biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr www.sciencedirect.com/science/arti...
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Steve Quinn @steve-quinn-lab.bsky.social · 30/07/2025
🚨 New preprint!🚨We introduce a DNA-scaffold strategy for efficient dye labelling of structured RNAs, enabling #smFRET studies of freely-diffusing SARS-CoV-2 pseudoknots🧬 👉 biorxiv.org/content/10.1... #smFRET #RNA #biophysics #SARSCoV2 #singlemolecule #Covid
biorxiv.org
A DNA scaffold approach facilitates 5′ labelling of the SARS-CoV-2 RNA pseudoknot for smFRET investigation
Single-molecule Förster resonance energy transfer (smFRET) studies of highly structured RNA molecules are often frustrated by issues with efficient dye conjugation. Here, we develop a DNA scaffold-bas...
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Steve Quinn @steve-quinn-lab.bsky.social · 21/07/2025
🚨New Preprint! Latest research led by @jemmabetts.bsky.social & @chillzaa.bsky.social reveals the structure of a protein-dependent riboswitch, revealing new mechanistic principles that could inspire novel antivirals! Thanks @ukri.org, @ei-science.bsky.social, @ybri-uoy.bsky.social for support! 🔬
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Centre for Blood Research @cbr-uoy.bsky.social · 18/07/2025
Yorkshire Cancer Research hosted the White Rose Cancer Report launch event in Sheffield on 3rd July Yorkshire is one of the regions hardest hit by cancer Karen, David and Geoff shared their positive experiences, and how patient-centric care has literally saved their lives
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Dimitris Lagos @dimitrislagos.bsky.social · 15/07/2025
We have a new 3-year PDRA post in Cancer Immunology. Ideal if you have a background in T cells, ideally human, and are interested in cancer immunology and RNA medicine. It’ll be fun! www.jobs.ac.uk/job/DNV085/r... Funded by ‪@yorkagainstcancer.bsky.social‬ @hyms.ac.uk @ybri-uoy.bsky.social
jobs.york.ac.uk
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Department of Biology, University of York @biologyatyork.bsky.social · 10/07/2025
(1/4) Three new pieces of research have been published from the ProteoStem ( www.proteostem.co.uk ) research group @billgrey.bsky.social working in @biologyatyork.bsky.social @ybri-uoy.bsky.social @cbr-uoy.bsky.social
proteostem.co.uk
Homepage - Proteo Stem
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Faria Tryps Lab @fariatrypslab.bsky.social · 05/07/2025
www.nature.com/articles/s41... Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
nature.com
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications
Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...
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Department of Biology, University of York @biologyatyork.bsky.social · 01/07/2025
New review on synthetic HEG drives in Ae. aegypti from Joshua Ang and Luke Alphey (@ybri-uoy.bsky.social‬) They examine challenges, propose the CHIROS framework to guide future development, and discuss paths forward for this vector control strategy. pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Synthetic Homing Endonuclease Gene Drives to Revolutionise Aedes aegypti Biocontrol - Game Changer or Pipe Dream?
The increasing burden of Aedes aegypti-borne diseases, particularly dengue, is a growing global concern, further exacerbated by climate change. Current control strategies have proven insufficient, nec...
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Department of Biology, University of York @biologyatyork.bsky.social · 30/06/2025
Congratulations to @bridgekatherine.bsky.social who has been awarded an @The_MRC New Investigator Research Grant! This £0.83M award will enable her laboratory to research hijacked hypoxia signalling in blood cancer @ybri-uoy.bsky.social @biologyatyork.bsky.social
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Centre for Blood Research @cbr-uoy.bsky.social · 26/06/2025
Blood Cancer Survivor and founder of the York Haematology Support Group Carol Miller told That's TV why she thinks being part of a community can help people manage the anxiety of receiving a diagnosis. www.york.ac.uk/biomedical-r...
york.ac.uk
World Blood Cancer Day: Interview with Carol Miller
Blood Cancer Survivor Carol Miller was interviewed by That's TV on World Blood Cancer Day.
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Chris H. Hill @chillzaa.bsky.social · 20/06/2025
I'm thrilled and honoured to receive the 2025 Lister Prize, along with seven other fantastic biomedical scientists 🔬🦠🧬 This award will enable us to determine high-resolution structures of viral protein synthesis inside infected cells
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York Biomedical Research Institute @ybri-uoy.bsky.social · 06/06/2025
A pleasure to host Prof James B. Rowe as our final speaker for the 2024-25 BMS seminar series James presented his work on the effect of dementia on causal circuits. Incredible to hear his expertise as an active consultant neurologist and Director of Cambridge Centre for Frontotemporal Dementia
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Aidan Horner @aidanhorner.bsky.social · 04/06/2025
Today the York Neuroimaging Centre (YNiC) is celebrating its 20th Birthday with a series of talks from amazing present and past researchers! @yorkpsychology.bsky.social @ybri-uoy.bsky.social
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Lucy Stafford @lucysta02475610.bsky.social · 29/05/2025
Also happy to do this with Masters (and PhDs) outside of the Psychology department @ybri-uoy.bsky.social @uoy-sociology.bsky.social @familywellbeinguoy.bsky.social @uoylangling.bsky.social @uoyenvironment.bsky.social @uoyeducation.bsky.social ⬇️
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Faria Tryps Lab @fariatrypslab.bsky.social · 27/05/2025
So happy to share the first preprint from our lab on post-transcriptional regulation at the VSG expression-site body in trypanosomes. @ybri-uoy.bsky.social @york.ac.uk
biorxiv.org
Specialised RNA decay fine-tunes monogenic antigen expression in African trypanosomes
Antigenic variation is a sophisticated immune evasion strategy employed by many pathogens. Trypanosoma brucei expresses a single Variant-Surface-Glycoprotein (VSG) from a large genetic repertoire, whi...
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York Biomedical Research Institute @ybri-uoy.bsky.social · 23/05/2025
Pleased to host Prof Federico Brandalise as our Biomedical Science seminar speaker today, hosted by Prof Will Brackenbury, funded by @physoc.bsky.social Federico presented his work on the voltage-gated sodium channel's impact on glioblastoma progression
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York Biomedical Research Institute @ybri-uoy.bsky.social · 15/05/2025
It was a pleasure to host the @britsocimm.bsky.social Yorkshire Group Symposium 2025 this week, chaired by Dr Ioannis Kourtzelis The event provided a platform for ECRs from across the region to present their work on host-pathogen interactions, immune regulation in haematology, and skin immunology
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York Biomedical Research Institute @ybri-uoy.bsky.social · 14/05/2025
Delighted to host our Dementia Day today, where we'll be hearing from researchers from across the faculty of sciences at York, and our two external invited speakers
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York Biomedical Research Institute @ybri-uoy.bsky.social · 09/05/2025
Delighted to host @alanawelm.bsky.social @utah.edu as our International Biomedical Seminar today! Hosted by @andrewholding.bsky.social Alana shared her work on modeling metastatic breast cancer to advance therapeutic strategies Great to collaborate globally with experts in their field 👨‍🔬🌍👩‍🔬
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Andrew Holding @andrewholding.bsky.social · 07/05/2025
Still time to sign up for this talk tomorrow. Professor Alana Welm will be talking her work developing patient derived models for cancer therapy.
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York Biomedical Research Institute @ybri-uoy.bsky.social · 02/05/2025
Reminder that our online seminar is taking place next Friday 9th May, 2.00-3.30pm, hosted by @andrewholding.bsky.social! Make sure to sign up on the Eventbrite so you can receive the details for the live stream 😀 www.eventbrite.co.uk/e/ybri-onlin...
eventbrite.co.uk
YBRI Online Biomedical Sciences Seminar 2025
Join our online biomedical sciences seminar open to UG, PG students, postdocs, ECRs and Group Leaders!
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York Biomedical Research Institute @ybri-uoy.bsky.social · 25/04/2025
A real honor to host Sir Professor Paul Nurse @crick.ac.uk as a special guest for our Friday Biomedical Science seminars Paul shared his insights into eukaryotic cell cycle control, and a multitude of stories from his decorated career
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York Biomedical Research Institute @ybri-uoy.bsky.social · 24/04/2025
We're delighted to be hosted Prof Welm for our online seminar this year! Make sure you register so you can access details to the live stream. We look forward to seeing you there 👩‍🔬🌍👨‍🔬
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Dimitris Lagos @dimitrislagos.bsky.social · 22/04/2025
We have a 3-year PDRA post in Cancer Immunogenomics. Ideal to use and strengthen your bioinformatics skills to discover how cancer transcriptome quirks shape immunotherapy outcomes. Funded by @cancerresearchuk.org. It’ll be fun! jobs.york.ac.uk/vacancy/rese... @hyms.ac.uk @ybri-uoy.bsky.social
jobs.york.ac.uk
Jobs - The University of York
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York Biomedical Research Institute @ybri-uoy.bsky.social · 14/03/2025
Delighted to host Dr Christelle Langley @uniofcam.bsky.social as a speaker for our #biomedicalscience seminar series Hosted by Prof Beth Jefferies Christelle presented her research on the long-term effects of serotonin modulation on the brain and behaviour #psychiatry #mentalhealth #SSRI
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Nath Jones @drnathjones.bsky.social · 04/03/2025
New preprint: results from a collaborative project funded by the GCRF Global Network for NTDs investigating Leishmania deubiquitinase 16 as a potential drug target. @ybri-uoy.bsky.social @mottramlab.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Structure and Activity of the Essential UCH Family Deubiquitinase DUB16 from Leishmania donovani
In Leishmania parasites, as for their hosts, the ubiquitin proteasome system is important for cell viability. As part of a systematic gene deletion study, it was discovered that four cysteine protease...
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uofytechs.bsky.social @uofytechs.bsky.social · 05/03/2025
#job 🚨for a laboratory technician in the Wright group within dept. Biology/HYMS and @ybri-uoy.bsky.social to work on creating genome-scale arrays of human cell surface receptors to discover new host-pathogen interactions. Apply by 20/3/2025: jobs.york.ac.uk/vacancy/labo...
jobs.york.ac.uk
Jobs - The University of York
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