Sign in

Lucas Dent

@cellsandculture.bsky.social
1.2K followers 1.3K following 10 posts

cell.codes Australian Researcher, Alumni of: Charras Lab. London Centre for Nanotechnology, Bakal Lab, ICR. PhD, Harvey Lab, Peter Mac Plant powered 🌱 Fascinated about how cells work #SystemsBio #CellShape #MechBio #Rstats #Imaging #MorphoGenesis

PostsRepliesMedia
Reposted by Lucas Dent
ZechLab @zech-lab.bsky.social · 19/11/2025
An exciting project to understand cellular ageing in health
and disease. Deadline for applications is 4th Dec. Pis don't hesitate to
contact us if interested.

https://www.findaphd.com/phds/project/mrc-dimen- doctoral-training-partnership-stopping-premature-ageing: investigating-the-role-of-actomyosin-mediated-nuclear-
force-feedback-in-cell-homeostasis/?p189509

Please also see our websites for research interests:
Tobias
Zech: https://tzech6.wixsite.com/zechlab
• Chris Toseland: https://www.toseland-
lab.com
174
Reposted by Lucas Dent
Reto Fiolka @retof.bsky.social · 12/11/2025
Felix Zhou's u-Segment3D is out: www.nature.com/articles/s41... It leverages 2D cell segmentations from orthoviews to generate a ‘consensus’ 3D segmentation. It does a great job on segmenting densely packed samples, and we have used the algorithm in many applications.
17717
Reposted by Lucas Dent
Joachim Goedhart @joachimgoedhart.bsky.social · 30/09/2025
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
Figure 1: Fluorophore intensity in the Drosophila blastoderm (n.c. 14). Comparison of (A) green and (B) red fluorescence intensity using the same intensity scaling in n.c. 14. The fluorescence signal did
not saturate. Shown are single imaging planes. Normalised histograms of fluorescence intensity for green (C) and red (D) fluorophores averaged across at least n=3 embryos per line. Scale bars = 20 μm
15426
Reposted by Lucas Dent
Florian Schur @schurlab.bsky.social · 25/09/2025
Huntingtin binds and bundles F-actin! Thrilled to team up with the Humbert (Sorbonne Université) and Song (KAIST) labs on this discovery. We had a blast doing cryo-ET on this unexpected complex — and now so many new questions lie ahead! #TeamTomo #CryoET #HTT #actin doi.org/10.1126/scia...
14512
Lucas Dent @cellsandculture.bsky.social · 01/09/2025
Please vote for Frankie’s image 👇 (if you like it!). Frankie is screening compounds to regenerate heart muscle. Your vote will help raise funds for this remarkable work.
050
Reposted by Lucas Dent
Giulia Paci @giuliapaci.bsky.social · 11/08/2025
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
510842
Reposted by Lucas Dent
Lucas Waltzer @lucaswaltzer.bsky.social · 03/06/2025
#drosophila @flybase.bsky.social request emergency funding: "As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate! www.philanthropy.cam.ac.uk/give-to-camb...
philanthropy.cam.ac.uk
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
381102
Reposted by Lucas Dent
Julia Eckert @juliaeckert.bsky.social · 01/05/2025
Started my first day as a Walter Benjamin Fellow! 🥳 Looking forward to study symmetry-breaking in morphogenesis using and connecting concepts from soft matter physics & cell/molecular biology @yap-lab.bsky.social. 👉 physics meets biology! Big thanks to the @dfg.de for funding my research.
1353
Reposted by Lucas Dent
Julia Eckert @juliaeckert.bsky.social · 25/05/2025
Our new review paper from @yap-lab.bsky.social is online - together with Virgile Viasnoff! 👉 'New directions in epithelial mechanoadaptation' www.sciencedirect.com/science/arti...
15221
Reposted by Lucas Dent
Frank Schnorrer @frankschnorrer.bsky.social · 10/05/2025
Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social www.science.org/doi/epdf/10....
34930
Reposted by Lucas Dent
UCL IPLS @ucl-ipls.bsky.social · 08/04/2025
📢Registration is open for our IPLS Annual Symposium, 11th June 2025! We will showcase exciting #interdisciplinary #research performed by IPLS researchers and collaborators. Limited spaces, register early to avoid disappointment 👇 ucl.ac.uk/physics-livi...
067
Reposted by Lucas Dent
Andreas Prokop @poppi62.bsky.social · 02/05/2025
Has been added to our history collection on droso4public: droso4public.wordpress.com/history/
droso4public.wordpress.com
History
On this page we collate articles explaining the history of Drosophila research, for all those who want to better understand the roots of all the wonderful work being done with flies in contemporary…
0137
Reposted by Lucas Dent
Benoit Ladoux @bladoux.bsky.social · 19/04/2025
Flocking and active solid behavior of epithelial cells in our new study in @pnas.org Great work of Y. Shen, J. O'Byrne and @andreasschoenit.bsky.social and collaboration with A. Maitra and R. Voituriez! | PNAS www.pnas.org/doi/10.1073/...
15516
Lucas Dent @cellsandculture.bsky.social · 15/04/2025
We’ve had an incredible experience being hosted at the AIC at Janelia for iPALM imaging. Tremendous support and expertise. If your project could benefit from advanced imaging, check out their instruments (FIB-SEM, iPALM, LLSM and others) and get in touch.👇
075
Reposted by Lucas Dent
Beth Cimini 🔬💻📊 @bethcimini.bsky.social · 08/04/2025
If you train people in ImageJ, Fiji, whatever, even if it isn't your day job, please let us know, and please share this post! Thanks a ton, we really appreciate it. (2/2) forms.gle/C8dUpg8qZkbD... #bioimaging #microscopy #bioimageanalysis
forms.gle
Open Source Bioimage Analysis Training Survey
We are attempting for a publication to estimate the number of biologists who have attended a tutorial or training course in open source bioimage analysis (especially user friendly tools, but anything ...
13242
Reposted by Lucas Dent
Guillaume Jacquemet @guijacquemet.bsky.social · 07/04/2025
Here we share our opinions on "Practical considerations for data exploration in quantitative cell biology" journals.biologists.com/jcs/article/... Joanna, Hanna and I worked quite a bit on this piece and I hope you find it useful Many thanks to @jcellsci.bsky.social for publishing it
journals.biologists.com
Practical considerations for data exploration in quantitative cell biology
Summary: We present practical guidelines for data exploration in quantitative cell biology that are designed to help yield reliable conclusions and promote a collaborative, transparent approach to dat...
47736
Reposted by Lucas Dent
Andrew Goryachev @andrewgoryachev.bsky.social · 04/04/2025
For all you interested in small GTPase biology and membrane pattern formation - this is an essential read from the labs of Peter Bieling and Bill Bement www.embopress.org/doi/full/10....
12510
Reposted by Lucas Dent
Erwin Frey @physicsoflifelmu.bsky.social · 31/03/2025
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter. 🔗 www.nature.com/articles/s41... #biophysics #syntheticcell #softmatter
113440
Reposted by Lucas Dent
Australian BioImage Analysts' Society @ausbias.org · 24/03/2025
AusBIAS is now on bluesky! We have a website, a logo, and a dream to connect all the bioimage analysts in Australia.
01310
Reposted by Lucas Dent
Ardem Patapoutian @ardemp.bskyverified.social · 21/03/2025
"How are memories formed and stored in the brain?...Long-term memory acquisition was found to be associated with a selective increase in multisynaptic boutons..". Groundbreaking new study from my friend and colleague Anton Maximov's lab: www.science.org/doi/10.1126/... Bonus: My son Luca's first pub
science.org
Synaptic architecture of a memory engram in the mouse hippocampus
Memory engrams are formed through experience-dependent plasticity of neural circuits, but their detailed architectures remain unresolved. Using three-dimensional electron microscopy, we performed nano...
210721
Reposted by Lucas Dent
Lucien Hinderling @lhinderling.bsky.social · 23/02/2025
PREPRINT OUT ✨ "hack" your microscope to work as a 3D printer! print micrometer sized features at cm scale. a method for easy and cheap microfabrication, with a focus on biological applications. THREAD ↓ www.biorxiv.org/content/10.1...
1014757
Reposted by Lucas Dent
Tianyang Liu @tianyang22.bsky.social · 31/01/2025
Working on actin cytoskeleton and Arp2/3 complex? Check out our latest work~https://www.biorxiv.org/content/10.1101/2025.01.31.635869v1 In this work, we found SPIN90 forms a dimer, facilitating bidirectional actin filament nucleation by activating two Arp2/3 complex #Cryo-EM #Actin #Arp2/3
12211
Reposted by Lucas Dent
Harmit Singh Malik @harmitmalik.bsky.social · 28/01/2025
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.
12783595
Reposted by Lucas Dent
Jérôme Gros @jeromegros.bsky.social · 28/01/2025
Announcing this upcoming conference: GASTRULATION RELOADED: Developing, engineering, and evolving the body plan Join us as we explore the latest research on gastrulation and axis formation/elongation, featuring common, exotic, and synthetic embryos! 📅 14–17 October 2025 📍 Paris, France
35429
Reposted by Lucas Dent
Eurico Morais-de-Sá @polarityi3s.bsky.social · 15/11/2024
First official post! A new paper out about #cytokinesis in #epithelia www.embopress.org/doi/full/10.... Explore our journey as we uncover how regulators of cell-cell and cell-matrix interactions modulate cytokinesis efficiency, while revealing new roles for the Dystrophin-Dystroglycan complex.
15014
Reposted by Lucas Dent
Daniel S. Brooks @dsbrooks.bsky.social · 26/01/2025
If you're interested in theory in biology, please consider applying for this EMBO|FEBS Lecture Course "Emergence & Evolution of Multi-Level Regulatory Systems", organized by @yoginho.spore.social.ap.brid.gy, @nrepina.bsky.social, and James DiFrisco. meetings.embo.org/event/25-mul... #philsci #evobio
meetings.embo.org
Venice Summer School 2025: Emergence & Evolution of Multi-Level Regulatory Systems
Biological systems comprise multiple levels of organization , from molecules, organelles, and cells, to the multi-cellular structures that form whole tissues, organisms, and ultimately societies and …
14532
Reposted by Lucas Dent
Pablo J. Sáez @pjsaez.bsky.social · 05/01/2025
Interesting study by Delgado et al Lennon lab (@institutcurie.bsky.social), shows that Arp2/3 regulates Langerhans cells & nuclear shape, #cellmigration, and genome stability [In collab with @manellab.bsky.social, Benvenuti, Fachinetti, @sandraiden.bsky.social] Full www.biorxiv.org/content/10.1...
083
Reposted by Lucas Dent
Jim Woodgett @jwoodgett.bsky.social · 08/12/2024
A long read from 2017 but well worth the time for any scientist who both loves their job and and often finds themselves questioning their life decisions. www.danielnettle.org.uk/wp-content/u...
danielnettle.org.uk
511445
Reposted by Lucas Dent
Jonny Coates @jacoates.bsky.social · 14/12/2024
14. There are huge benefits to converting your current journal clubs into preprint review clubs. *Share usable feedback and improve science *Help ECRs build a public track record *Actual training op-ed: buff.ly/3zjLltQ You could post the reviews to @prereview.bsky.social too! #PreprintAdvent
buff.ly
Journal clubs 2.0: An update for the 21st century
Do you run a journal club? The non-profit, scientist-driven ASAPbio (Accelerating Science and Publication in Biology) promotes transparency and innovation in life science communication, and they are offering funding to organise preprint review clubs. Find out about their other activities, too.
02517
Reposted by Lucas Dent
Richard Sever @richardsever.bsky.social · 18/12/2024
Important point from Editor of @plosbiology.org . See the two "Content verification" sections here journals.plos.org/plosbiology/...
journals.plos.org
Biomedical publishing: Past historic, present continuous, future conditional
Academic journals have been publishing the results of biomedical research for more than 350 years. Reviewing their history reveals that the ways in which journals vet submissions have changed over tim...
096
Reposted by Lucas Dent
Susana Godinho @susanagodinho.bsky.social · 11/12/2024
We have a very cool (I know I am biased😁) project for a computational biologist (postdoc) interested in cancer evolution in collaboration with Nicky McGranahan’s lab! Perfect opportunity to expand your computational skills too! 👉 www.godinholab.com RT please 🙏🙏🙏👍👍
godinholab.com
Godinho Lab
13635
Reposted by Lucas Dent
Rainero lab @erainerolab.bsky.social · 18/12/2024
Our recent paper is now highlighted in #Kudos: link.growkudos.com/1pwlc1v9n28
link.growkudos.com
Eating matrix components stimulate cancer cell migration and invasion
Cancer cells interact with their surroundings, known as the extracellular matrix, to grow and spread. While it is known how cancer cells break down the matrix externally, less is known about how they ...
053
Reposted by Lucas Dent
Thomas Feliciani @thofel.bsky.social · 09/12/2024
I found a great excuse to make a bunch of fun ggplots. As if I needed one. github.com/thomasfelici... -- #rstats #generative #ggplot #rayshader
github.com
GitHub - thomasfeliciani/2024_cover_images: Walk-through for generating the images used on the book cover and chapter pages of my PhD dissertation.
Walk-through for generating the images used on the book cover and chapter pages of my PhD dissertation. - thomasfeliciani/2024_cover_images
1235
Reposted by Lucas Dent
Manuel Mendoza @longchrom.bsky.social · 09/12/2024
1/ One more preprint before the holidays! In which we find that chromatin compaction scales with cell size from interphase through mitosis. A collaboration from waaay back (see end of thread) with Melike Lakadamyali @melikel.bsky.social and Jerome Solon. A thread: 👇 www.biorxiv.org/content/10.1...
biorxiv.org
Chromatin Compaction Follows a Power Law Scaling with Cell Size from Interphase Through Mitosis
Coordination of mitotic chromosome compaction with cell size is crucial for proper genome segregation during mitosis. During development, DNA content remains constant but cell size evolves, necessitat...
1279
Reposted by Lucas Dent
Lucien Hinderling @lhinderling.bsky.social · 08/12/2024
Here is a movie locally activating RhoA from our paper doi.org/10.7554/eLif... See fig. 4 for details. Our OptoLARG construct (pB3.0-optoLARG-mVenus-SspB-p2A-stargazin-mtq2-iLID) is adapted from this publication: doi.org/10.1038/ncom...
1209
Reposted by Lucas Dent
Josiah Passmore @jpassmore.bsky.social · 08/12/2024
Sure! 🐌
1235
Reposted by Lucas Dent
Guillaume Jacquemet @guijacquemet.bsky.social · 02/12/2024
Let's share some other classic, the beautiful Cells in culture film directed by Michael Abercrombie one of the father of quantitative cell imaging (University College London, 1955) is available here identity.wellcomecollection.org/works/z6h7jzv4
identity.wellcomecollection.org
Cells in culture.
<p>The opening sequences are of normal cell behaviour in colour. Isolated cells showing active movement. Streaming of packed cells - movement. Contact inhibition. Mouse muscle fibroblasts. Abnormal be...
27719
Reposted by Lucas Dent
Manuel Thery @manuelthery.bsky.social · 27/11/2024
Mix two motors of opposite polarity with microtubules and they will partition space ! Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns. #morphogenesis doi.org/10.1073/pnas... (1/n)
8365102
Reposted by Lucas Dent
Basil Greber @bjgreber.bsky.social · 06/12/2024
New pre-print! To support a CDK-cyclin docking motif discovery and characterisation project led by Norman Davey and colleagues, @natalia-mg.bsky.social in my lab determined the #cryoEM structures of three peptide-bound CDK2-cyclin A complexes. Check it out! www.biorxiv.org/content/10.1...
biorxiv.org
High-throughput discovery and deep characterization of cyclin-CDK docking motifs
Cyclin-CDKs are master regulators of cell division. In addition to directly activating the CDK, the cyclin subunit regulates CDK specificity by binding short peptide “docking” motifs in CDK substrates...
14417
Reposted by Lucas Dent
Xavier Trepat @xaviertrepat.bsky.social · 03/12/2024
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1
519147
Reposted by Lucas Dent
John Wallingford @jbwallingford.bsky.social · 02/12/2024
Welcome to the #devbiolwriteclub Bluesky Boot Camp! I’ll be posting here regularly with thoughts and exercises to help scientists become better writers. Let’s start by managing expectations: I will NOT help you write better. I WILL help you become a better writer. 🧵 1/10
38640
Reposted by Lucas Dent
Dave Barry @david-j-barry.bsky.social · 26/11/2024
#CBIAS2024 attendees group photo. Is there a collective noun for a dense group of image analysts?
CBIAS 2024 attendees group photo
113314
Reposted by Lucas Dent
Chris Bakal @cbakal.bsky.social · 26/11/2024
In May we published in #CellReports describing our study using high-throughput #lightsheet microscopy to investigate the #3D morphogenesis of melanoma cells during invasion, a process critical to #metastasis. Part of the Dynamical Cell Systems Team in-focus 2024. buff.ly/415jwBn
052
Reposted by Lucas Dent
Chris Bakal @cbakal.bsky.social · 17/11/2024
#Sentinal4D and my lab at the Institute of Cancer Research have developed Al methods to analyze videos of #cancer cells, and measure how #cellshape changes over time. We are using this technology to understand how drugs work, and find new cancer therapeutics. link.springer.com/chapter/10.1...
link.springer.com
Interpretable Phenotypic Profiling of 3D Cellular Morphodynamics
The dynamic 3D shape of a cell acts as a signal of its physiological state, reflecting the interplay of environmental stimuli and intra- and extra-cellular processes. However, there is little quantita...
053
Reposted by Lucas Dent
Mark A. Hanson @hansonmark.bsky.social · 19/11/2024
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on? direct.mit.edu/qss/article/... A 🧵 1/n #AcademicSky #PhDchat #ScientificPublishing #SciPub
44994558
Reposted by Lucas Dent
The Company of Biologists @biologists.bsky.social · 25/11/2024
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at: @dev-journal.bsky.social @jcellsci.bsky.social @jexpbiol.bsky.social @dmmjournal.bsky.social @biologyopen.bsky.social @the-node.bsky.social @prelights.bsky.social @focalplane.bsky.social
10437211
Reposted by Lucas Dent
Su-In Lee @suinlee.bsky.social · 24/11/2024
Here’s the updated Computational Biology Starter Pack! Let me know if you'd like to be included. go.bsky.app/QVPoZXp
8017577
Reposted by Lucas Dent
Noam Ross @noamross.net · 23/11/2024
At @rOpenSci.hachyderm.io.ap.brid.gy we're pairing first-time code contributors with experienced maintainers. If you are an rOpenSci or other #RStats package author and want to help build the road for new contributors and get co-maintainers, sign up for co-working! ropensci.org/blog/2024/10...
ropensci.org
Looking for Maintainers to Support First-Time Contributors
Announcing a Community Call and Coworking sessions to support first contributions
02616
Reposted by Lucas Dent
Sylvain Gabriele @sgabriele.bsky.social · 21/11/2024
Pre-announcing the 10th Biennial European CellMech conference organized in Leuven 🇧🇪 from September 30th to October 3rd, 2025. cellmech2025.org Save the date !
04528
Reposted by Lucas Dent
Reto Fiolka @retof.bsky.social · 21/11/2024
Mitofilin/MIC60 in an U2OS cell, imaged with our latest generation oblique plane microscope (OPM). OPM is a light-sheet technique where both illumination and detection go through the same primary objective.
1366