Jürgen Knoblich may be best known for his work on cerebral organoids at IMBA, but his nearly 30-year career in Vienna began at the IMP, where his group deciphered the molecular mechanisms of asymmetri...

With organoids, assembloids and a growing toolkit of bioengineering tricks, scientists are stitching together models of the developing human brain — and pushing the limits of realism and control.

Lindenhofer, Haendeler, Esk, Littleboy et al. perform whole-tissue lineage tracing in human cerebral organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage siz...

Human brain organoids are powerful in vitro models for brain development and disease. However, their variability can complicate use in biomedical research and drug discovery. Both the specific protoco...