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Michaela Horger

@callmemich.bsky.social
349 followers 328 following 1 posts

PhD candidate in the Grotjahn lab at Scripps Research (grotjahnlab.org) Interested in organelle/cytoskeleton interactions 🩷🩷 Big mito girl!

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Reposted by Michaela Horger
Teng-Leong Chew @scopeshifu.bsky.social · 28/07/2026
🧪 Want to image specimens that require air-liquid interface on a microscope with water-dipping lenses such as the lattice light sheet system? @aicjanelia.bsky.social, @cmhobson.bsky.social and TokaiHIT have just made that a reality. Check out our new paper: www.nature.com/articles/s44...
nature.com
Adapting upright light sheet fluorescence microscopy for imaging at air-liquid interface - npj Imaging
npj Imaging - Adapting upright light sheet fluorescence microscopy for imaging at air-liquid interface
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Reposted by Michaela Horger
Nitish Dua @nitishdua.bsky.social · 27/06/2026
Really hyped to share our pre-print on mtDNA replication-fission ! @nanigrotjahn.bsky.social (doi: doi.org/10.64898/202...) 🧵with details below ⤵️
doi.org
ATAD3A structurally links mtDNA replication and mitochondrial fission
Mitochondrial function depends on the maintenance of its genome, and disruptions in copy number and distribution are hallmarks of mitochondrial disorders. Mitochondrial DNA (mtDNA) replication is spat...
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Reto Fiolka @retof.bsky.social · 05/05/2026
@aqlm.bsky.social Quite reasonable requests…
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Elias Spiliotis @septinlab.bsky.social · 11/04/2026
A book chapter we wrote awhile ago: Peering into the Septin Cytoskeleton – New Insights Unlocked by Microscopy Advances Andrew W. Schaefer and Elias T. Spiliotis onlinelibrary.wiley.com/doi/abs/10.1... Out now in the new Royal Microscopy Society book "Live Biological Imaging Across Scales"
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Nick Talbot @talbotlabtsl.bsky.social · 07/04/2026
A new study from our group, led by Iris Eisermann, of the septin interactome during appressorium development, revealing many new interactors and significantly widening the biological function of septins in fungal pathogenesis. 👇 @thesainsburylab.bsky.social
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Jan-Hannes Schaefer @jhschaef.bsky.social · 07/04/2026
We identified the maltoside detergent DM as an effective and easy solution to address preferred orientation in cryo-EM. Helped me switch from graphene grids. Special congrats to Maria Rafiq! @landerlab.bsky.social @nanigrotjahn.bsky.social @wisemanlab.bsky.social #cryoEM doi.org/10.64898/202...
Blender Rendering of vitrified HA trimer with DM at the air-water interface
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Reposted by Michaela Horger
Cell Biology J-Club @cellclub.bsky.social · 06/04/2026
MitoAtlas: a Domain-Resolved Spatial Map of the Human Mitochondrial Proteome www.biorxiv.org/content/10.6...
biorxiv.org
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Devine lab @devinelab.bsky.social · 13/03/2026
⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...
cell.com
MitoTracker transfers from astrocytes to neurons independently of mitochondria
The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...
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Reposted by Michaela Horger
Juan C. Landoni @jclandoni.bsky.social · 03/04/2026
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
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James Barrett @james-r-barrett.bsky.social · 30/01/2026
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!: www.biorxiv.org/content/10.6... @cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social #Rubisco #PhaseSeparation #Condensates #Pyrenoid
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Maggie Utgaard @maggieutgaard.bsky.social · 23/01/2026
So excited to share the preprint with the bulk of my PhD work in the Beach @myosincity.bsky.social and Oakes @pwoakes.bsky.social Labs at Loyola University Chicago! We investigate the structure, recruitment, and function of septin networks around the nucleus. A thread: doi.org/10.64898/202...
doi.org
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Journal of Cell Biology @jcb.org · 05/01/2026
Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/... #CryoET
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Reposted by Michaela Horger
Ben Barad @baradlab.com · 26/12/2025
Online today, the journal version of our ( @nanigrotjahn.bsky.social @attychang.bsky.social @mmedina300kv.bsky.social) manuscript from earlier this year describing membrane thickness measurement in cells with #teamtomo! rupress.org/jcb/article/...
rupress.org
Surface Morphometrics reveals local membrane thickness variation in organellar subcompartments | Journal of Cell Biology | Rockefeller University Press
Medina, Chang et al. introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar membranes fro
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Michaela Horger @callmemich.bsky.social · 22/12/2025
Honored to be featured in the current issue of Cytoskeleton as a part of the Cytoskeleton Scholars program! Many thanks to @justinparreno.bsky.social for coordinating this profile onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
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Yamuna Krishnan @krishnanyamuna.bsky.social · 17/12/2025
Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
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Luc Reym⌬nd @lreymond.bsky.social · 16/12/2025
New paper from @zhixingchen2.bsky.social's lab! It turns out that, in addition to its very low phototoxicity, PKmito Deep Red (PKMDR) directly reports on mitochondrial membrane potential (MMP) in live cells through its lifetime! www.nature.com/articles/s41...
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Julius Winter @julius-w.bsky.social · 11/12/2025
Using photoconversion, volumetric imaging, mitochondrial segmentation, and network simulations, we identified a distinct, proliferative mitochondrial subpopulation positioned around the nucleus. From there, single mitochondria scatter new material across the cell, maintaining network in balance
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Journal of Cell Biology @jcb.org · 05/12/2025
@attychang.bsky.social, @nanigrotjahn.bsky.social et al. show that cytoplasmic #ribosomes on #mitochondria alter the local membrane environment for protein import. rupress.org/jcb/article/... 📕 From The Year In Cell Biology: rupress.org/jcb/collecti... #CellBio2025
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Juanma García-Arcos @juanmagararc.bsky.social · 27/11/2025
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
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Julia Métraux @juliametraux.bsky.social · 15/11/2025
What a privilege it is to be a younger disabled person in a community shaped by Alice Wong. Rest in peace, Alice.
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Reposted by Michaela Horger
Claire Deo @clairedeo.bsky.social · 13/11/2025
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇 www.biorxiv.org/content/10.1...
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Tom Iwanicki @iwanicki.bsky.social · 14/10/2025
Kailua Beach, Hawai’i: The first time I laid eyes on a By-the-wind sailor, I stopped dead in my tracks, dusted the sand off my hands, grabbed my iphone and...
 close-up of a by-the-wind sailor on a white background
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Rebecca R Helm @rebeccarhelm.bsky.social · 09/10/2025
Many sea stars begin life as young fairy-like creature (called a brachiolaria) that float through the open ocean. Eventually, a small star forms within them (here in yellow). The fairy-like brachiolaria sinks under the star’s weight, and the star pops out! 🎥@the_story_of_a_biologist (on Insta)
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Nadja M. Hümpfer @nadjahuempf.bsky.social · 30/09/2025
It is out! 🦚 I recorded hundreds of #ExM 🔬images of cytokinetic bridges and averaged them into 6 stages. How? With help from our fantastic collaborators @zacsimile.bsky.social and @jonasries.bsky.social in Vienna 😇. Check out the full atlas here: doi.org/10.5281/zenodo.17232370
Sketches of six stages of cytokinetic development of the intercellular bridge are illustrated with exmaple U-ExM fluorescence microscopy images. Septin2-GFP shown in green. Tubulin shown in magenta. A shortened workflow illustrates the image alignment and averaging process to generate average 2D reconstructions of cytokinetic stages.
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Merja Joensuu @joensuulab.bsky.social · 01/10/2025
🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉 🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
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FocalPlane @focalplane.bsky.social · 05/09/2025
In this week's preprint list we highlight a jumbo crop of #preprints focussed on new tools and techniques in imaging🔬. Check it out here, and let us know if you’ve come across a preprint that we’ve missed: focalplane.biologists.com/2025/09/05/m...
focalplane.biologists.com
Microscopy preprints - new tools and techniques in imaging - FocalPlane
Microscopy preprints - new tools and techniques in imaging - News
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Jonatan Alvelid @jonatanalvelid.bsky.social · 02/09/2025
Excited to share my postdoc work from the Eggeling lab in Jena (@leibnizipht.bsky.social, #FSUJena, #KTHuniversity) on bringing smart microscopy to super-resolution MINFLUX: event-triggered MINFLUX microscopy.
Demonstrative schematics and example timeline of event-triggered MINFLUX microscopy.
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Catherine Rampell @crampell.bsky.social · 29/08/2025
Trump admin planning to change student visas from lasting for duration of academic program to fixed 4-yr term, and then much harder to renew Could destroy US ability to attract global talent, particularly those seeking advanced degrees in STEM. The median time to complete a PhD is 5.7 yrs per NSF.
forbes.com
Trump Deals A New Immigration Blow To International Students
Trump officials have proposed a new rule limiting international students to fixed periods of entry, making a U.S. education more precarious.
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Sam Lewis, Ph.D. @samlewis.bsky.social · 29/08/2025
arxiv.org/abs/2506.05643
arxiv.org
Diffusive Spreading Across Dynamic Mitochondrial Network Architectures
Networks of physical units can vary from a stationary set of spatially-embedded links to a collection of mobile agents that undergo transient social interactions. In living cells, mitochondria form ar...
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Reposted by Michaela Horger
Current Biology @currentbiology.bsky.social · 28/08/2025
Feeling mitochondrially challenged lately? Here are two classic reviews on #mitochondria that should help. www.cell.com/current-biol... www.cell.com/current-biol...
cell.com
The Origin and Diversification of Mitochondria
Moving beyond the simplistic view of mitochondria as the power house of the cell, Roger et al. present the immense diversity of mitochondria and mitochondrial functions across eukaryotes, and bring th...
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Andy Moore @aaandmoore.bsky.social · 18/08/2025
This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.
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Seth Tomchik @sethtomchik.bsky.social · 08/08/2025
Spreadsheet documenting the administration's systematic attacks on biomedical research (currently focused on NIH). Given the revolving set of pretexts deployed for each attack, keeping tabs on the big picture may help cut through the noise. docs.google.com/spreadsheets...
docs.google.com
Federal Science Policy Tracker
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Marine Biological Laboratory @mblscience.bsky.social · 19/05/2025
It's #MicroscopyMonday, so let's take a look into the microscope! 🔬 This image shows muscle detail in the arms of the California two-spot octopus (Octopus bimaculoides), color-coded for depth. It was also the winner of the 2019 MBL Photo Contest! 📷: Allan Carrillo-Baltodano
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Journal of Cell Science @jcellsci.bsky.social · 19/05/2025
After the success of our 2023 Imaging Cell Dynamics conference, we’ll be hosting a second #JCSImaging meeting in 2026, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social‬, @drmichaelway.bsky.social‬ & Giulia Zanetti. To register your interest: www.biologists.com/meetings/jcs...
Journal of Cell Science Meeting 2026 
Imaging Cell Dynamics
Date: 11 – 14 May 2026
Venue: Montanyà Hotel, Catalonia, Spain
Register your interest
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Danielle Grotjahn @nanigrotjahn.bsky.social · 01/05/2025
🚨New preprint!🚨 #teamtomo We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles. Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science
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Atty (Ya-Ting) Chang @attychang.bsky.social · 10/04/2025
Feeling so honored and thrilled to see our work make it to the cover—what a milestone in my career! I can’t wait to receive the poster from JCB🤩
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Danielle Grotjahn @nanigrotjahn.bsky.social · 23/11/2024
Labs that clay together, stay together 🩶🌪️🥣 @hamid13r.bsky.social @mmedina300kv.bsky.social @callmemich.bsky.social @nitishdua.bsky.social
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Jennifer Waters @jencwaters.bsky.social · 04/11/2024
An excellent primer on co-localization analysis from Federico Gasparoli! youtu.be/Mv4M1HaYdBc @fedegasparoli.bsky.social
youtu.be
Introduction to Colocalization in Fluorescence Microscopy
YouTube video by Microcourses
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Juan C. Landoni @jclandoni.bsky.social · 12/11/2024
#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added! #Mito #Mitochondriac go.bsky.app/J6Bu5fL
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