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Devine lab

@devinelab.bsky.social
152 followers 246 following 8 posts

Devine lab at @crick.ac.uk We study how mitochondria regulate neuronal synapses and how that regulation goes wrong in diseases that affect the brain Posts by lab members | Views are own

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Devine lab @devinelab.bsky.social · 24/08/2026
Here we describe step-by-step how to visualise dopaminergic release in acute brain slices, using the fluorescent false neurotransmitter 200 (FFN200). This protocol can be used with other FFNs, and explains steps from imaging🔬 to data analysis✅
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Devine lab @devinelab.bsky.social · 24/08/2026
We are excited to share a new paper from our lab presenting a protocol developed by Patrick Cottilli during his PhD placement at Sulzer lab in Columbia University, NY www.cell.com/star-protoco...
cell.com
Protocol for fluorescent false neurotransmitter live imaging of dopamine release dynamics from individual synapses in acute brain slices
Striatal dopaminergic (DA) axons have many en passant boutons with synaptic vesicles, but only a fraction display exocytosis. Here, we present a protocol for live imaging of murine DA axons using fluo...
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Reposted by Devine lab
Ali Twelvetrees @dozenoaks.bsky.social · 09/03/2026
Save the date for #NeuroBioUK26 Do you like neurons? Maybe glia? Molecules? Cell biology? - The venue is booked and we are excited to see you and your incredible science there on the 11th of September! Please do join our email list to stay up to date. neurobiouk.sites.sheffield.ac.uk
An image montage advertising NeuroBioUK - 11th of September 2026 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.
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Devine lab @devinelab.bsky.social · 13/03/2026
⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...
cell.com
MitoTracker transfers from astrocytes to neurons independently of mitochondria
The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...
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Devine lab @devinelab.bsky.social · 21/11/2025
Check out the first review from the Mitochondrial Neurobiology lab on... lysosomes! Learn about the non-canonical roles of lysosomes in neurons from @jonnyspencer.bsky.social @ysudarikova.bsky.social: www.cell.com/trends/neuro...
cell.com
Non-canonical roles of lysosomes in neurons
Neurons are highly polarised and compartmentalised cells with organelles that are specialised to support their spatial and functional demands. This includes lysosomes, which are single-membrane-bound ...
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Devine lab @devinelab.bsky.social · 20/11/2025
Congratulations to Dr. Patrick Cottilli who has successfully defended his PhD viva yesterday!!🎉 This is a huge milestone for our lab - our first-ever PhD graduate!⭐ So proud of your hard work, creativity, and perseverance throughout these 4 years. Here's to the amazing science ahead!🔬
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Reposted by Devine lab
Rupert Beale @bealelab.bsky.social · 10/10/2025
Do you want to do a PhD with me and Mike Devine? Of course you do! Or if not, maybe you know someone who does? @devinelab.bsky.social www.crick.ac.uk/careers-stud...
crick.ac.uk
Beale & Devine Lab | Role of the V1H subunit of the V-ATPase in neurons and cell-autonomous immune responses
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Devine lab @devinelab.bsky.social · 05/06/2025
We are excited to share a new preprint from our lab led by Katy Hole (@drkhole.bsky.social) in collaboration with MSD (UK).
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