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Nick Talbot

@talbotlabtsl.bsky.social
3.3K followers 1.1K following 341 posts

Interested in plant pathology, fungal development, cell biology. I study a disease called rice blast and work at The Sainsbury Laboratory. Views my own.

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Reposted by Nick Talbot
Fantin Mesny @mesny.bsky.social · 13m
5 years ago, @hacquardst.bsky.social and I became very interested in 𝑃𝑙𝑒𝑐𝑡𝑜𝑠𝑝ℎ𝑎𝑒𝑟𝑒𝑙𝑙𝑎 𝑐𝑢𝑐𝑢𝑚𝑒𝑟𝑖𝑛𝑎, an emerging fungal pathogen that colonizes the roots of many plants 🌱 🍅 🌾 🆕📝 Final result of a huge team effort to uncover the bases of its multi-host compatibility👇 www.nature.com/articles/s41...
nature.com
Carbohydrate-active enzymes from a core root mycobiota member enable infection of multiple plant hosts - Nature Microbiology
Host-induced fungal CAZymes act as disease determinants and drive multihost compatibility.
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Reposted by Nick Talbot
Robert Arkowitz @robertarkowitz.bsky.social · 30/09/2026
www.nature.com/articles/s41...
nature.com
Quantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell Biology
Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...
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Sophien Kamoun @kamounlab.bsky.social · 30/09/2026
All pumped up to speak at PurPest @purpest-eu.bsky.social event: From Science to Innovation What science can (and cannot) deliver--Excellence, people, and the long game
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Reposted by Nick Talbot
The Sainsbury Laboratory @thesainsburylab.bsky.social · 29/09/2026
@ahbucknell.com @adnroide.bsky.social @gene-boy.bsky.social @jonathandgjones.bsky.social @talbotlabtsl.bsky.social
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Mariana Schuster @marischuster.bsky.social · 07/09/2026
I'm excited to share that my newly funded #ERCStG FRONTERA is recruiting two postdoctoral researchers at @ipbhalle.bsky.social 🌱🔬 If you are passionate about plant immunity, proteolysis, membrane proteins, or proteomics, I'd love to hear from you. 🧵 Please RT/share!
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Robert Arkowitz @robertarkowitz.bsky.social · 27/09/2026
www.ucsf.edu/news/2026/09...
ucsf.edu
UCSF’s Kevan Shokat Wins Stephenson Prize for Cancer Breakthrough
Kevan Shokat, PhD, a professor of Cellular and Molecular Pharmacology at UC San Francisco who discovered how to disable KRAS, a seemingly unstoppable cancer-driving protein, has won the Stephenson Glo...
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Prof. Keiko Torii @keikoutorii.bsky.social · 24/09/2026
I am proud to share my No-AI-assisted perspective review "Plant Peptide Hormones: Three Decades of Discovery and Emerging Paradigms" for the Centennial issue of @plantphys.bsky.social 🌱🍅. It's OA, so everyone can access! 1/ academic.oup.com/plphys/advan...
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Frederica Theodoulou @freddietheodoulou.bsky.social · 24/09/2026
@jonathandgjones.bsky.social asks: Science can keep up with pathogen evolution, but can regulation keep up with the science? #PrecisionBreeding #UKPB26
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Nick Talbot @talbotlabtsl.bsky.social · 24/09/2026
Cologne Cathedral tonight in the evening sun.
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Isabel saur @izzysaurlab.bsky.social · 23/09/2026
@sfb1403.bsky.social CD symposium in progress. Great to have all these great speakers here!
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Isabel saur @izzysaurlab.bsky.social · 23/09/2026
@bactodeath.bsky.social speaks as the first ‚plant representetive’ at the @sfb1403.bsky.social Cell death symposium! -> great diversity of metacaspase funtions
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Reposted by Nick Talbot
Andrew Urquhart @starships-andrew.bsky.social · 24/09/2026
Another step in the #Starship story - they move via a circular intermediate. Helps explain how these elements horizontally transfer and means that we can modify them into transformation vectors (starmids). www.biorxiv.org/content/10.6...
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Nick Talbot @talbotlabtsl.bsky.social · 23/09/2026
In Cologne for International Symposium of Cell Death - fantastic interdisciplinary group assembled here. #CellDeath
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Neil Gow @neil-gow.bsky.social · 19/09/2026
Great to be at the Myk2026 in Graz and see my good friend and long term colleague receiving a long term achiement award from the German Soc of Medical Mycology. @ishamycology.bsky.social @mrccmm.bsky.social @youngecmm.bsky.social
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Rob 🇨🇦 @rockinbones.bsky.social · 16/09/2026
#ColorADay #RedWed #Lichen
Lichen with British Soldiers
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Nick Talbot @talbotlabtsl.bsky.social · 16/09/2026
The Autumnal feel of a freshly ploughed field #Norfolk
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UK Centre for Ecology & Hydrology (UKCEH) @ukceh.bsky.social · 15/09/2026
🍄‍🟫💻 Explore UKCEH’s new Fungi Explorer, an interactive tool revealing the hidden world of soil fungi across Great Britain using DNA data from 1,000+ Countryside Survey soil samples. Search species, map distributions, or match your own DNA sequences. connect-apps.ceh.ac.uk/fungal-explo…
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The Plant Cell @theplantcell.bsky.social · 15/09/2026
Decoding plants cell by cell: opportunities and challenges in single-cell and spatial biology (Lieven De Veylder , Maite Saura-Sanchez , Bert De Rybel , Tatsuya Nobori , Klaas Vandepoele , Lorenzo Caputi , Sarah E O’Connor , Jian Xu) doi.org/10.1093/plce... #PlantScience @aspbofficial
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Nick Talbot @talbotlabtsl.bsky.social · 14/09/2026
Latest preprint from our group. We found the Bip1 transcription factor is phosphorylated in a Pmk1-dependent manner & with Mst12 co-regulates appressorium-specific functions, as well as acting on genes associated with invasive growth. @camilla-moli.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
A Pmk1-Regulated Mst12-Bip1 Network Coordinates Appressorium Function, Effector Deployment, and Invasive Growth by Magnaporthe oryzae
To cause rice blast disease, the filamentous fungus Magnaporthe oryzae develops a specialised infection cell called an appressorium, which generates enormous turgor to breach the rice leaf cuticle. Al...
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Reposted by Nick Talbot
Camilla Molinari @camilla-moli.bsky.social · 14/09/2026
Thank you to all the co-authors for your contributions! 🌾 Neha Sahu @lauren23.bsky.social Xia Yan @vgeshkovski.bsky.social @tatsuyanobori.bsky.social and @talbotlabtsl.bsky.social
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Camilla Molinari @camilla-moli.bsky.social · 14/09/2026
5) Together, this maps a Pmk1 → Mst12 ↔ Bip1 circuit required for appressorium function, effector deployment, and invasive growth by M. oryzae.
Model of a Pmk1-dependent Mst12-Bip1 transcriptional progam for rice blast infection.
Three-layered MAPK activation, mediated by upstream sensors and a RAS-dependent phosphorelay,
activates the Pmk1 MAPK, which is required for appressorium formation, maturation and invasive
growth. Activated Pmk1 subsequently phosphorylates Mst12, which controls penetration, polarity,
and septation through regulation of septin and actin ring assembly at the appressorium pore, while
also repressing a number of effector proteins prior to plant infection. Mst12 binds a cis-regulatory
element in the BIP1 promoter to drive its transcription. Bip1 regulates primary metabolism during
conidial germination its Mst12-mediated expression and Pmk1-dependent phosphorylation are
required for effector regulation, PKS gene regulation and invasive growth. Together, Mst12 and Bip1
co-regulate a large set of infection-related genes, while Bip1 controls a distinct set of effectors
associated with invasive growth by the rice blast fungus.
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Reposted by Nick Talbot
Camilla Molinari @camilla-moli.bsky.social · 14/09/2026
4) Genome-wide, Bip1 and Mst12 jointly control 2,600+ genes, and together switch on about half of the fungus's effector repertoire required to colonise the host.
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Reposted by Nick Talbot
Camilla Molinari @camilla-moli.bsky.social · 14/09/2026
3) We also find that Mst12 directly binds a BIP1 promoter element required for appressorium-mediated infection.
Schematic representation of the BIP1 promoter and gene sequence, highlighting the motif bound by Mst12. Below two chimeric versions of the promoter where the motif is deleted or substituted by a sequence of poly-T.Barley infection assays showing that the Mst12 binding motif found in the BIP1 promoter is required for M. oryzae infection. When this motif is deleted or replaced by a sequence of poly-T, M. oryzae cannot infect the host. This is the same phenotype observed for the bip1 mutant
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Reposted by Nick Talbot
Camilla Molinari @camilla-moli.bsky.social · 14/09/2026
3) We find that Pmk1 regulates a recently discovered bZIP transcription factor in M. oryzae, Bip1. It does this transcriptionally and post-translationally, through phosphorylation.
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Reposted by Nick Talbot
Camilla Molinari @camilla-moli.bsky.social · 14/09/2026
2) Appressorium development and infection are regulated by Pmk1, a MAPK that controls a network of transcription factors, including the conserved Mst12.
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Reposted by Nick Talbot
Camilla Molinari @camilla-moli.bsky.social · 14/09/2026
1) To infect, Magnaporthe oryzae builds a specialised cell, the appressorium, that ruptures through the leaf using huge internal pressure, switching on nearly half its genome to do so.
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Reposted by Nick Talbot
Camilla Molinari @camilla-moli.bsky.social · 14/09/2026
Excited to share this pre-print from my PhD work! We explore a Pmk1-Mst12-Bip1 network required for appressorium-mediated infection by the blast fungus 🌾 www.biorxiv.org/content/10.6... Thread 👇
biorxiv.org
A Pmk1-Regulated Mst12-Bip1 Network Coordinates Appressorium Function, Effector Deployment, and Invasive Growth by Magnaporthe oryzae
To cause rice blast disease, the filamentous fungus Magnaporthe oryzae develops a specialised infection cell called an appressorium, which generates enormous turgor to breach the rice leaf cuticle. Al...
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Reposted by Nick Talbot
Gladfelter Lab @gladfelterlab.bsky.social · 26/07/2026
You're probably already doing science advocacy — you just might not call it that. Our new commentary (www.nature.com/articles/s41...) makes the case that every scientist has a role, and that advocacy takes many forms. Find and embrace yours! @natcellbio.nature.com @vfarm15.bsky.social
nature.com
Every scientist has a role in advocacy - Nature Cell Biology
In this Comment, we call on scientists to share their stories. Through casual conversation or prepared presentations, with images or essays, scientists can advocate for their research and reach taxpay...
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Reposted by Nick Talbot
Michael Feldbrügge @mfeldbruegge.bsky.social · 02/09/2026
Two PhD positions in the Feldbrügge Lab at HHU Düsseldorf within nEXt-RNA: 🔬 DC1: Live-cell imaging of RNA transfer and function 📦 DC10: Mechanisms and applications of RNA delivery RNA biology, fungi, extracellular vesicles and advanced imaging. www.mikrobiologie.hhu.de/en/
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Michelle Momany @mcmomany.bsky.social · 11/09/2026
UGA Fungal Group 2026. Love these colleagues. They put the FUN in fungi!
UGA Fungal group 2026
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Robert Arkowitz @robertarkowitz.bsky.social · 11/09/2026
www.cdc.gov/fungal/funga...
cdc.gov
Fungal Disease Awareness Week
Join CDC each September for Fungal Disease Awareness Week (FDAW). <em>Think fungus</em> to save lives.
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Sophien Kamoun @kamounlab.bsky.social · 10/09/2026
A fantastic @johninnescentre.bsky.social session at #BSPP26, showcasing an impressive range of pathosystems across wheat, legumes and brassicas 🌾🫘🥬 #PPATH2026 #PlantHealth
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Nick Talbot @talbotlabtsl.bsky.social · 11/09/2026
Van Schepler-Luu on the challenge of controlling bacterial blight of rice IRRI #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 11/09/2026
Evaluating endophytic control of forage grass and wheat diseases - extarodinary potential of Epichloë in wheat from @youngkiwi.bsky.social #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 11/09/2026
Nyambura Mwangi identifying endophytes to protect sugarbeet from stubby root nematodes #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 11/09/2026
Gustaf Fredell identifying Epichloë and Chaetomium endophyes that might colonise barley for biocontrol evaluation against fungal diseases #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 11/09/2026
With my PhD supervisors Alan Coddington (now 92!) and Richard Oliver (a little younger!) #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 11/09/2026
Developing Epichloë endophytic strains to provide protection to wheat from insects and fungal diseases, building on its success in ryegrass where the majority in New Zealand is not protected from insect herbivory in this way. Richard Johnson #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 11/09/2026
David Collinge on innovative biological control interventions to protect against Fusarium head blight #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 10/09/2026
Fascinating structure-guided analysis of NRC network activation dynamics and how sensor-helper NLR interactions lead to resistosome formation in plant immunity @mpcontreras.bsky.social #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 10/09/2026
Developing novel forms of crop resistance based on an understanding of NLR biology so that resurrection of resistance specificities can be generated and deployed. @cianduggan.bsky.social ResurrectBio #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 10/09/2026
Remarkable live cell imaging of spatiotemporal dynamics of helper NLR activation at extra-haustorial and plasma membranes, while others target organellar membranes @tolgaboz.bsky.social #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 10/09/2026
Exploring natural variation as a means of generating novel forms of disease resistance and new understanding of the nature of plant immunity, from @gittacoaker.bsky.social #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 10/09/2026
Cryo-electron tomography of protein complexes in Magnaporthe infection structures - amazing imaging and exrraordinary potential for understanding infection biology from @delaconcepcionjc.bsky.social #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 10/09/2026
Inspiring overview of how to generate novel forms of wheat and rice blast resistance through understanding effector-NLR interactions from Ryohei Terauchi - here quoting Haldane's far-sighted comments on immunity #PPATH2026
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Sophien Kamoun @kamounlab.bsky.social · 09/09/2026
Vivianne Vleeshouwers @VivianneTwit on how NLR and PRR immune receptors work together to resist the potato late blight pathogen, Phytophthora infestans. 🥔🦠🌱 #BSPP26 #PPATH2026 #PlantHealth
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Nick Talbot @talbotlabtsl.bsky.social · 09/09/2026
Keynote talk from Vivianne Vleeshouwers on identifying novel sources of disease resistance in potato - late blight, phytoplasmas and how to use wild species as reservoirs of novel resistance #PPATH2026
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Nick Talbot @talbotlabtsl.bsky.social · 09/09/2026
Presidential address kicking off #PPATH2026 - the remarkable biology of phytoplasmas presented by @saskiahogenhout.bsky.social
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Team Thomma @teamthomma.bsky.social · 08/09/2026
📣...and now for something completely different: no plant pathogens, no Verticillium, but lichens! Driven by our lichen king🤴@ciarankelly.bsky.social with help of a.o. @hroevenich.bsky.social @usadellab.bsky.social @vivienrosenthal.bsky.social Watch for more in future! www.biorxiv.org/content/10.6...
biorxiv.org
Decoupled evolution of antimicrobial repertoires in lichen-forming fungi
Lichens are stable multipartite symbioses in which a fungal mycobiont associates with one or more photosynthetic partners while hosting complex microbiomes. Secreted antimicrobial proteins (AMPs) have...
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Juan Carlos De la Concepcion @delaconcepcionjc.bsky.social · 08/09/2026
The beauty of posting in @biorxivpreprint.bsky.social. This amazing tool was available for the community long before it showed up on a journal. I even forgot this publication was not "peer-reviewed", but it was definitively "community-reviewed". Kudos to @lorenzlamm.bsky.social and all the authors!
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