Muscle function depends on the ability of myofibrils to withstand and repair mechanical damage, yet how adult muscles remodel damaged myofibrils remains poorly understood. Here, we establish a Drosoph...

UNIVERSITY OF MICHIGAN FACULTY POSITION IN CELL & MOLECULAR BIOLOGY AND RELATED FIELDS   The Department of Molecular, Cellular, and Developmental B...

Low aerobic capacity in patients with long COVID and ME/CFS is often attributed to physical inactivity. The authors show that long COVID and ME/CFS patients have distinct skeletal muscle changes that ...

The mitochondrial phosphatase PPTC7 is required to sustain mammalian metabolism, as its global knockout (KO) triggers hypoketotic hypoglycemia and perinatal lethality in mice. However, the extent to w...

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

The University of Cambridge wishes to appoint a talented and ambitious laboratory postdoctoral research associate to join the research groups of Prof Patrick Chinnery, Prof Rita Horvath and Dr Jelle v...

Aging kidneys exhibit mitochondrial structural defects, oxidative stress, fibrosis, and altered metabolism. A new study published in Aging Cell suggests that alterations in the mitochondrial contact s...

Recent studies have highlighted major roles for skeletal muscle in human health, yet most of the underlying mechanisms remain to be explored, from molecules to the organism. This EMBO Workshop will a…

In eukaryotic cells, mitochondria form networks that range from highly fused interconnected structures to fragmented populations of individual orga...

Using single-cell tissue imaging and spatial proteomics to study mitochondria–lipid droplet coupling in hepatocytes, PLIN5 phosphorylation is identified as a mediator of lipid flux and nutrient stress...

The main function of mitochondria is to generate ATP by oxidizing pyruvate to CO2. Rauseo et al. show that matrix pyruvate is also converted to lactate, which is released to the cytosol via the MPC to...

mTORC1 does not always hold the key to unlocking the mechanical load-induced growth of skeletal muscle.

Using live-imaging in vivo and ex vivo, Sarde et al. show that dystrophic muscle stem cells have precocious differentiation through symmetric divisions and impaired migration, with differential impact...

Job title: Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037), Employer: The Norwegian School of Sport Sciences , Deadline: Wednesday, March 11, 2026

Winner of the Vilcek Prize for Creative Promise, Akera’s novel research findings have huge implications for infertility and chromosomal disorders.

Abstract The mitochondrial reticulum of skeletal muscles has been characterized in the 1970-80s. It has been suggested and then proven its role is delivering energy in a form of transmembrane potentia...

Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...

Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to ...

Non-peripheral (displaced) myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to th...

Cryogenic electron microscopy structures and functional analyses reveal that NCLX functions as a H+/Ca2+ rather than a Na+/Ca2+ exchanger, and uncover its transport mechanism with implications for the...

Berezhnaya et al. showed that MICU2 is present in the brain during development but is replaced during maturation by MICU3. MICU2 loss during development results in neuronal overmigration in the cortex...

Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...