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Robert Seaborne

@robertseaborne.bsky.social
178 followers 84 following 40 posts

Lecturer at King’s College London. Co-affiliate positions at The University of Copenhagen and The Blizard Institute London

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Robert Seaborne @robertseaborne.bsky.social · 20/03/2026
It's been a long time since I sat down and enjoyed reading a paper cover-to-cover as much as this. Some cracking work and experiments. www.science.org/doi/10.1126/...
science.org
Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism
mTORC1 does not always hold the key to unlocking the mechanical load-induced growth of skeletal muscle.
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Professor Adam P. Sharples @profadamsharples.bsky.social · 04/03/2026
1 week left to apply! We are recruiting a Post‑Doc in Skeletal Muscle Molecular Physiology, Oslo, Norway Join our EMMA multi‑omics project on mitochondrial epigenetic memory in human muscle ageing. 4‑year position. Start May 2026. Apply: www.jobbnorge.no/en/available...
jobbnorge.no
Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037) | The Norwegian School of Sport Sciences
Job title: Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037), Employer: The Norwegian School of Sport Sciences , Deadline: Wednesday, March 11, 2026
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Robert Seaborne @robertseaborne.bsky.social · 27/02/2026
We now have a lab website: muscleomicslab.github.io It has taken a while to write the code, update and is still a WIP, but it does a fair job of describing who we are, what we do and who funds us. We are always looking for collabs so please spread the word (& website)
muscleomicslab.github.io
The Seaborne Lab | Muscle-Omics
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Robert Seaborne @robertseaborne.bsky.social · 02/12/2025
Final few days to apply for a postdoc pos. in our lab. If you have a passion for large data sets, data integration, sequencing and plenty of problem solving, then this could be for you! Initial 12 months, but with a further 19months available for the right candidate! www.jobs.ac.uk/job/DPK467/p...
jobs.ac.uk
Postdoctoral Research Associate in Computational Muscle Biology at King's College London
Apply for the Postdoctoral Research Associate in Computational Muscle Biology role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
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Robert Seaborne @robertseaborne.bsky.social · 02/12/2025
Final few days to apply for a postdoc pos. in our lab. If you have a passion for large data sets, data integration, sequencing and plenty of problem solving, then this could be for you! Initial 12 months, but with a further 19months available for the right candidate! www.jobs.ac.uk/job/DPK467/p...
jobs.ac.uk
Postdoctoral Research Associate in Computational Muscle Biology at King's College London
Apply for the Postdoctoral Research Associate in Computational Muscle Biology role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
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Reposted by Robert Seaborne
Robert Seaborne @robertseaborne.bsky.social · 12/11/2025
Please share far & wide. Looking for a #postdoc to get stuck in with a wide range of projects, with freedom to explore and lead the #computational #bioninformatics work 12 months to begin with, but for the right candidate we have funding for a further 19 months www.jobs.ac.uk/job/DPK467/p...
jobs.ac.uk
Postdoctoral Research Associate in Computational Muscle Biology at King's College London
Discover Postdoctoral Research Associate in Computational Muscle Biology jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.
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Reposted by Robert Seaborne
Julien Ochala @droch.bsky.social · 13/11/2025
Excited to present our recent work on myosin as a molecular target for genetic muscle diseases! Kudos to all authors, especially Elise, Fanny and @myofinlab.bsky.social @ucph.bsky.social
insight.jci.org
JCI Insight - Myosin inhibition partially rescues the myofibre proteome in X-linked myotubular myopathy
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Robert Seaborne @robertseaborne.bsky.social · 12/11/2025
Please share far & wide. Looking for a #postdoc to get stuck in with a wide range of projects, with freedom to explore and lead the #computational #bioninformatics work 12 months to begin with, but for the right candidate we have funding for a further 19 months www.jobs.ac.uk/job/DPK467/p...
jobs.ac.uk
Postdoctoral Research Associate in Computational Muscle Biology at King's College London
Discover Postdoctoral Research Associate in Computational Muscle Biology jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.
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Robert Seaborne @robertseaborne.bsky.social · 10/11/2025
Recruiting a comp PDRA for the lab 🚨 Working on multiple projects using integrated multi omics in bulk & single cell level Passion for data, coding, bioinformatics & keen to lead our labs comp workflow 12 months in first instance but extendable for further 19 months my.corehr.com/pls/coreport...
my.corehr.com
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Robert Seaborne @robertseaborne.bsky.social · 29/10/2025
We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!
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Robert Seaborne @robertseaborne.bsky.social · 06/10/2025
Little under a week left to apply for this position to come and lead some cool experiments in muscle biology in London!
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Julien Ochala @droch.bsky.social · 29/09/2025
We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere
employment.ku.dk
14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme
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Robert Seaborne @robertseaborne.bsky.social · 25/09/2025
🚨Second position available in the lab. Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell. Please spread the word! kcl-mrcdtp.com/project/the-...
kcl-mrcdtp.com
The brain-muscle epigenetic interplay in neuromuscular disease - MRC DTP
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease marked by progressive motor neuron loss. Emerging evidence suggests a critical, previously underappreciated role for skeletal muscle in ALS onset and progression, highlighting pathological and molecular interplay between brain and muscle. However, systematic, high-resolution molecular analyses across these tissues remain scarce. This project will use advanced […]
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Julien Ochala @droch.bsky.social · 25/09/2025
Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social
kcl.ac.uk
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
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Robert Seaborne @robertseaborne.bsky.social · 25/09/2025
🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important Good collab with @droch.bsky.social so travel to CPH involved as well www.kcl.ac.uk/jobs/126245-...
kcl.ac.uk
Postdoctoral Research Associate in Muscle Biology and Genomics | King's College London
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Robert Seaborne @robertseaborne.bsky.social · 16/09/2025
Denmark is a country very difficult not to fall in love with www.science.org/content/arti...
science.org
I thought science hinged on prestige. Moving abroad made me reassess my priorities
In Denmark, this Ph.D. student fell in love with an egalitarian society that values work-life balance
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Robert Seaborne @robertseaborne.bsky.social · 13/08/2025
Very happy to have been awarded a NIRG from the MRC. Stay tuned for some exciting (I think, but being biased) postdoc positions within our lab!
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King's Faculty of Life Sciences & Medicine @kingslsm.bsky.social · 13/08/2025
Congratulations to Dr Robert Seaborne @kingscollegelondon.bsky.social who has been awarded a New Investigator Grant from the Medical Research Council (MRC), which will support his work on understanding the role of skeletal muscle in motor neurone disease. Read more ➡️ www.kcl.ac.uk/news/dr-robe...
Photo of Dr Robert Seaborne with quote: "The support from the MRC will allow our lab to apply novel methodologies that we have developed over the last ~5 years, to study motor neurone disease from a muscle perspective, giving us a greater opportunity to provide novel insights into the disease."
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Robert Seaborne @robertseaborne.bsky.social · 17/07/2025
Kings Prize Fellowship is now open, awarding funds for 18-24 months to an outstanding postdoc. If keen to come to KCL and work on molecular dynamics of single myofibers in healthy/diseased contexts, drop me a message! www.kcl.ac.uk/assets/resea...
kcl.ac.uk
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Robert Seaborne @robertseaborne.bsky.social · 25/06/2025
Fantastic opportunity for an ECR to establish their own group!
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Karolinska Institutet @ki.se · 18/06/2025
Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence
news.ki.se
KI to recruit junior researchers with a focus on excellence
On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility. As one of Europe’s leading medical universities, KI offe...
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Robert Seaborne @robertseaborne.bsky.social · 05/06/2025
Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes www.sciencedirect.com/science/arti....
sciencedirect.com
Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes
Recent decades have revealed increasing evidence for epigenetic inheritance through paternal environmental exposures and experiences, affecting offspr…
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Robert Seaborne @robertseaborne.bsky.social · 30/05/2025
A pleasure to play a very small part in a very large story (and just as big collaboration). From @nireynon.bsky.social team. Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration www.cell.com/cell-reports...
cell.com
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration
Jacques et al. conducted a thorough meta-analysis integrating multi-omics data from over 1,000 participants to identify distinctive molecular signatures in human skeletal muscle adaptation to various ...
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Robert Seaborne @robertseaborne.bsky.social · 24/05/2025
A wonderful time celebrating a fair few years of quality science! A few brain cells, papers, grants, experiments and beers developed, created and shared amongst these lads over the years!
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Robert Seaborne @robertseaborne.bsky.social · 16/05/2025
Wow! Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM www.nejm.org/doi/full/10....
nejm.org
Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM
Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...
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Rakyan Lab @rakyanlab.bsky.social · 08/05/2025
Nice!
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Jenni Laitila, PhD @laitilajenni.bsky.social · 06/05/2025
Another beautiful collaboration 🔬💪 Proof-of-principle of getting both functional and proteomics data from a single myofiber - even from our tiny nemaline myopathy ones! Thanks for all the fun times in the lab @robertseaborne.bsky.social
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Atul Deshmukh @adeshmukh.bsky.social · 06/05/2025
Excited to share another great collaborative effort — we successfully combined single muscle fiber proteomics with functional assays in the same fiber! This integrated approach allows a direct link between molecular composition and functional performance at the single cell/fiber level.
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Robert Seaborne @robertseaborne.bsky.social · 05/05/2025
Integrated single-cell functional-proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof-of-principle study Another collab between the labs @droch.bsky.social @adeshmukh.bsky.social physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com
Integrated single‐cell functional‐proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof‐of‐principle study
Abstract figure legend SMPFO uniquely develops data relating to the biophysical state of the sarcomeric protein, alongside global proteome profiling, on a single myofibre basis. Using this approach w...
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Robert Seaborne @robertseaborne.bsky.social · 30/04/2025
New collaborative paper from @droch.bsky.social group, combining SkM biopsy, single fascicle and single myofiber biophysical and molecular experiments in T2DM link.springer.com/article/10.1...
link.springer.com
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
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Julien Ochala @droch.bsky.social · 29/04/2025
Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes
link.springer.com
Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus - Diabetologia
Aims/hypothesis Disrupted energy balance is critical for the onset and development of type 2 diabetes mellitus. Understanding of the exact underlying metabolic mechanisms remains incomplete, but skele...
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Robert Seaborne @robertseaborne.bsky.social · 07/04/2025
Big thanks to @acmedsci.bsky.social for the 2 year grant that will fund a programme of work on skeletal muscle ageing. Looking forward to getting stuck into it! #Springboard25 acmedsci.ac.uk/more/news/sp...
acmedsci.ac.uk
Groundbreaking health research gets £7.6m boost as Academy funds emerging scientific leaders
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Robert Seaborne @robertseaborne.bsky.social · 31/03/2025
Computational analysis of DNA methylation from long-read sequencing www.nature.com/articles/s41...
nature.com
Computational analysis of DNA methylation from long-read sequencing - Nature Reviews Genetics
Long-read sequencing technologies can directly profile methylation modifications across the genome. In this Review, Fu et al. overview the long-read computational tools to identify and compare methyla...
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Robert Seaborne @robertseaborne.bsky.social · 24/03/2025
It’s a timely process, building your own lab as a new PI. Especially with very, very limited start up funding. So this is a small step, but we now have our own, fully functioning lab room with everything we need (… nearly)
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Robert Seaborne @robertseaborne.bsky.social · 11/03/2025
On the responsibilities of intellectuals and the rise of bullshit jobs in universities academic.oup.com/brain/articl...
academic.oup.com
On the responsibilities of intellectuals and the rise of bullshit jobs in universities
You may never have considered yourself to be one. Why would you? But if you’re reading this, there is more than a likelihood that you are one. If you’re a
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Robert Seaborne @robertseaborne.bsky.social · 07/03/2025
www.nature.com/articles/s41...
nature.com
Entering the era of deep single-cell proteomics - Nature Methods
Advances in single-cell proteomics allow quantification of half of the expressed proteome in an individual cell.
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Robert Seaborne @robertseaborne.bsky.social · 19/02/2025
A small part in a very big story. An exploration into drivers of heterogeneity in single muscle cells. A fantastic piece of work and a great collaboration. Human skeletal muscle fiber heterogeneity beyond myosin heavy chains | Nature Communications www.nature.com/articles/s41...
nature.com
Human skeletal muscle fiber heterogeneity beyond myosin heavy chains - Nature Communications
Moreno-Justicia and colleagues report transcriptomic and proteomic pipelines to explore heterogeneity within human skeletal muscle fibers, identifying sources of fiber heterogeneity in healthy individ...
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Robert Seaborne @robertseaborne.bsky.social · 14/02/2025
5-aza-2-deoxycytidine improves skeletal muscle function in a mouse model for recessive RYR1-related congenital myopathy academic.oup.com/hmg/advance-...
academic.oup.com
5-aza-2-deoxycytidine improves skeletal muscle function in a mouse model for recessive RYR1-related congenital myopathy
Abstract. RYR1-related congenital myopathies are rare disorders that severely impair muscle function and the quality of life of patients and their families
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Robert Seaborne @robertseaborne.bsky.social · 28/01/2025
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity www.nature.com/articles/s42...
nature.com
Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity - Nature Metabolism
Kdm2a demethylates H3K36me2 to mediate fast-to-slow-twitch myofiber transition and reshape skeletal muscle metabolic flexibility under metabolic stress conditions.
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Robert Seaborne @robertseaborne.bsky.social · 03/01/2025
Link between fatty acid oxidation and senescence! www.science.org/doi/10.1126/...
science.org
Mitochondrial fatty acid oxidation drives senescence
Nuclear DNA damage activates fatty acid–fueled mitochondrial energy metabolism to induce cellular senescence, a hallmark of aging.
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Arjun Raj @arjunraj.bsky.social · 12/12/2024
If peer-review really qualitatively improved papers, then if I had read the preprint, I would subsequently go read the reviewed version. But usually, if I've read the preprint, the message doesn't change, and I don't read the final version. Sure, papers get better… but not by much. 3/3
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Robert Seaborne @robertseaborne.bsky.social · 12/12/2024
Paper rejected. Grant submitted. Wine drunk. All in a days work…
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Robert Seaborne @robertseaborne.bsky.social · 27/11/2024
www.nature.com/articles/s41...
nature.com
Behind the graduate mental health crisis in science - Nature Biotechnology
Survey results identify how scientific research and teaching contribute to the graduate student mental health crisis.
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Robert Seaborne @robertseaborne.bsky.social · 19/11/2024
www.nature.com/articles/s41...
nature.com
Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
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Robert Seaborne @robertseaborne.bsky.social · 19/11/2024
For my second post; Anyone ever had a NIRG deemed fundable in a panel meeting and not be awarded due to funding restrictions, but held over to the following panel (5/6 months down the line) Only to be told the application is now deemed not fundable? Help! 🙃😬
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Robert Seaborne @robertseaborne.bsky.social · 18/10/2024
As my inaugural post here, im pleased to share our latest work Single Myofiber Protein Function-Omics, a novel method enabling inspection of underlying proteome landscape, coupled with protein functionality - with all data derived from the same single SkM cell... www.biorxiv.org/content/10.1...
biorxiv.org
Integrated single cell functional-proteomic profiling of human skeletal muscle reveals a shift in cellular specificity in nemaline myopathy
Skeletal muscle is a complex syncytial arrangement of an array of cell types and, in the case of muscle specific cells (myofibers), sub-types. There exists extensive heterogeneity in skeletal muscle f...
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