Sex differences have traditionally been attributed to gonadal hormones, but accumulating evidence shows that sex chromosomes exert distinct, cell-autonomous effects on health, aging, and disease. XX a...

Tumor-secreted ADAMTSL4 activates latent TGFβ1 at muscle cell surfaces, promoting muscle atrophy and fibrosis while also driving adipose tissue wasting, and represents a selective therapeutic target f...

Circadian regulation of proteostasis, a key determinant of muscle health, remains poorly understood. Here, we identify DNAJB6, an Hsp40 (DnaJ) co-chaperone, as a substrate of the circadian E3 ligase F...

Background Skeletal muscle is vital for mobility and metabolic regulation, impacting independence and overall health. Increases in skeletal muscle mass and contractile function during development, and...

Cancer cachexia limits treatment tolerance and survival in pancreatic ductal adenocarcinoma (PDAC), yet the tumor-derived signals driving tissue dysfunction remain poorly understood. Here, we identify...

Aging is the primary risk factor for most chronic diseases and is characterized in striated muscle by progressive functional decline, mitochondrial dysfunction, and chronic inflammation. The miR-128-1...

Background Skeletal muscle mass maintenance involves coordination of myofibers with mononuclear cell populations, including satellite cells, resident macrophages and fibro-adipogenic progenitors (FA...

Sarcopenia remains underdiagnosed and undertreated, partly because it continues to be mainly conceptualised as a disorder intrinsic to skeletal muscle. Although current definitions incorporate muscle ...

Protein entanglements can generate long-lived misfolded states, but their cellular fate is poorly understood. Here, the authors combine proteomics and simulations to show that entanglement misfolding ...

Reactive oxygen species (ROS) regulate protein function through reversible cysteine oxidation. In human skeletal muscle, exercise-induced ROS initiates adaptations such as mitochondrial biogenesis, in...

A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the molecular life sciences

Active self-organization of myoblasts, coupled with extracellular-matrix interactions, create mechanical stress patterns that bias cell fusion toward specific locations, providing a mechanistic link b...

How diet regulates cancer progression and therapeutic response is not completely understood. Here, the authors show that creatine supplementation promotes tumor metastasis by inducing hyperactive plat...

The mechanistic target of rapamycin (mTOR) pathway is an important integrator of processes involved in aging and longevity, coordinating nutrient sensing, metabolic adaptation, and cellular stress re

Bafilomycin A1-induced lysosomal dysfunction can be mitigated by CCA in muscle myotubes. The curcumin analogue C1 similarly decreases lysosomal accumulation, modestly improves function and increases ...

Seq-Scope maps skeletal muscle transcriptomes at high spatial resolution while preserving histological context, revealing distinct responses of myofibers, neuromuscular junctions, and stromal cells t...

Abstract figure legend β-Hydroxy-β-methylbutyrate (HMB) enhances fast-twitch muscle and mitochondrial function in D2.mdx mice. Male DBA/2J (wild-type) and D2.mdx mice aged 3 or 6 months received dail....

Disuse-induced muscle atrophy is driven by a non-metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4-mediated ubiquitination and degradation of the anti-a...

Nature - Quality control of glycogen through direct ubiquitylation by RNF213

5-Fluorouracil-based chemotherapies, such as FOLFOX (5-fluorouracil, leucovorin, oxaliplatin), are used to treat colon cancer but also induce skeletal muscle toxicities. While FOLFOX can disrupt muscl...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

<p>Sarcopenia, characterized by the progressive loss of skeletal muscle mass and function, is a major hallmark of aging. Post-translational modifications (PTMs) play essential roles in regulating prot...

The role of mtDNA integrity in muscle progenitor function remains poorly understood. Sen et al. show that mtDNA alterations in myoblasts impair myogenic differentiation and reshape the mitochondrial p...

1Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, United States of America

Shim and colleagues develop DLMEH, a metabolically stabilized D-leucine prodrug that bypasses first-pass catabolism. DLMEH activates Sestrin2-dependent mTORC1 signaling, restoring muscle protein synth...

Skeletal muscle stem cells (MuSC) are the guardians of muscle regeneration, sustaining tissue integrity through a delicate balance of quiescence, activation, and lineage commitment. While numerous mol...

Cell Death Discovery - Reorientation of the SUMOylation landscape and altered L3mbtl2-mediated transcriptional activity in cancer-associated muscle contractile dysfunction

CaMKII exemplifies antagonistic pleiotropy in skeletal muscle. Exercise-related Ca2+/redox signals drive transient CaMKII activation supporting youthful performance. Here we show CaMKII is upregulate...

Muscle stem cells orchestrate skeletal muscle regeneration through complex fate decisions. The transcriptional co-activators Yes-associated protein 1 (YAP) and WW domain-containing transcription regul...

Skeletal muscle adapts to exercise through rapid transcriptional remodeling, but regulators that link contractile activity to these gene programs remain unclear. Here we show that MAFF, a small MAF tr...

Abstract. Muscle satellite cells (MuSCs) are muscle-resident stem cells that are responsible for myofiber regeneration. Although the importance of calcium

There are currently no approved therapies for sarcopenia, the age-related loss of skeletal muscle mass and strength. This Review discusses advances in understanding of the cellular, molecular and meta...

Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disorder caused by mutations in the dystrophin gene that result in the absence of functional dystrophin, leading to progressive mus...

Mobility in humans and all animals depends on the co-ordinated progress of essential steps linking electrical action potentials along the surface membrane of muscle fibres to the increased cytoplasmic...

Sarcopenia is a progressive disease characterized by age-related decline in skeletal muscle force and mass. The fundamental molecular pathogenesis of sarcopenia has not yet been elucidated. Here, we s...

Tissue mitochondrial activity controls macrophage abundance by regulating CSF1 availability, thereby enabling efficient waste removal.

Abstract. Mutations in the Ky gene are the underlying cause of Myofibrillar Myopathy-7 (MFM-7), a rare progressive muscle weakness disease of childhood ons

The degradation and recycling of damaged proteins and organelles through autophagy is a vital process to maintain terminally differentiated cells under energy-demanding physiological conditions and me...

In this Review, the authors present distinguishing features for 62 cell types found in skeletal muscle and discuss how each cell type contributes to skeletal muscle function.

Sarcopenia, the age-related loss of skeletal muscle mass, strength, and function, contributes substantially to frailty, impaired mobility, chronic disease, and premature mortality. Central to its deve...

Exercise enhances skeletal muscle insulin sensitivity, but the signaling mechanisms responsible are poorly understood. Understanding them may open new therapeutic avenues for individuals with limited ...

A network of plasma membrane invaginations called t-tubules plays an essential role in controlling calcium release from the endoplasmic reticulum at the triads during muscle contraction. Although the ...

An organism’s external environment is dynamic and ever-changing. Survival depends on an animal’s ability to engage with its surroundings through adaptive and purpose driven movement. Organisms that re...