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Professor Adam P. Sharples

@profadamsharples.bsky.social
52 followers 59 following 38 posts

Professor of Molecular Physiology | Our Group 1st Demonstrated that Human Skeletal Muscle Possesses an Epigenetic Memory of Exercise -Our DNA Remembers Exercise! | ExProRugby

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Professor Adam P. Sharples @profadamsharples.bsky.social · 26/08/2026
Exciting milestone for npj Exercise Medicine & Health as it publishes its first articles under EIC @bluespotscience.bsky.social Delighted to serve as Editor for the Molecular Biology of Exercise Collection with Malene Lindholm & Zhen Yan www.nature.com/collections/... @natureportfolio.nature.com
nature.com
Molecular Biology of Exercise
Cutting-edge molecular and cellular research revealing how exercise drives adaptation, prevents chronic disease, and improves health.
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bluespotscience.bsky.social @bluespotscience.bsky.social · 26/08/2026
Today marks an exciting milestone as npj Exercise Medicine & Health publishes its first articles: www.nature.com/npjexercisem... Sincerel thanks to everyone for the amazing support. This is just the start of building a leading venue for high-quality research in exercise as medicine.
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Professor Adam P. Sharples @profadamsharples.bsky.social · 21/08/2026
New @npjExMedHealth Collection now open: Molecular Biology of Exercise @Nature_NPJ We welcome papers exploring the molecular & cellular mechanisms underpinning exercise adaptation in health, aging & disease nature.com/collections/... @Malene Lindholm @Zhen Yan @bluespotscience.bsky.social
nature.com
Molecular Biology of Exercise
Cutting-edge molecular and cellular research revealing how exercise drives adaptation, prevents chronic disease, and improves health.
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Professor Adam P. Sharples @profadamsharples.bsky.social · 29/07/2026
Exciting position in our department!
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ECSS @ecssofficial.bsky.social · 28/07/2026
@nih-sport-sciences.bsky.social is inviting applications for an Associate Professor/Professor in Sport Nutrition position in the Department of Physical Performance. The application deadline is 18 August 2026. 🔗 For details, visit bit.ly/3Tm49Tm #WeAreSportScience #JobOpening #FacultyPosition
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Professor Adam P. Sharples @profadamsharples.bsky.social · 01/07/2026
Proud to be part of this work in @NatureAging A pan-tissue methylation atlas revealing how ageing blends conserved programs with tissue-specific epigenetic drift Huge credit to Nir Eynon & Macsue Jacques for an outstanding study! #Aging #Epigenetics www.nature.com/articles/s43...
nature.com
Meta-analysis of DNA methylation aging signatures in 17 human tissues - Nature Aging
Jacques and colleagues present a cross-tissue meta-analysis of DNA methylation aging, revealing conserved aging signatures and modifiable gene clusters.
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Professor Adam P. Sharples @profadamsharples.bsky.social · 17/06/2026
New preprint! doi.org/10.64898/202... In BMI-discordant twins we integrate multi-omics across adipose & muscle Exercise reprograms adipose, shifting heavier twins towards a leaner baseline. Muscle improves insulin sensitivity & key molecular adaptations Amazing job: Jaakko Hentilä & Max Ullrich
doi.org
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Professor Adam P. Sharples @profadamsharples.bsky.social · 22/04/2026
Lovely visit @gihsweden for our Nordic muscle meeting! Great discussions with our founding members- Truls Raastad, @juhahulmi.bsky.social, Kristian Vissing, Niklas Psilander & great to talk muscle with Johanna Lanner @ferdinandvw.bsky.social & Lukas Moesgaard. Love the name of the Western lab!
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Professor Adam P. Sharples @profadamsharples.bsky.social · 04/03/2026
1 week left to apply! We are recruiting a Post‑Doc in Skeletal Muscle Molecular Physiology, Oslo, Norway Join our EMMA multi‑omics project on mitochondrial epigenetic memory in human muscle ageing. 4‑year position. Start May 2026. Apply: www.jobbnorge.no/en/available...
jobbnorge.no
Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037) | The Norwegian School of Sport Sciences
Job title: Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037), Employer: The Norwegian School of Sport Sciences , Deadline: Wednesday, March 11, 2026
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Professor Adam P. Sharples @profadamsharples.bsky.social · 25/02/2026
Our new study is now published in Advanced Science We show that skeletal muscle retains a molecular memory of disuse Young muscle shows transcriptional resilience Aged muscle shows exaggerated vulnerability advanced.onlinelibrary.wiley.com/doi/10.1002/...
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Professor Adam P. Sharples @profadamsharples.bsky.social · 18/02/2026
Now recruiting an experienced Post‑Doc in Skeletal Muscle Molecular Physiology @nih-sport-sciences.bsky.social Oslo, Norway Join our multi‑omics EMMA project on mitochondrial epigenetic memory in human muscle aging 4‑year position Start May Apply at Jobbnorge: www.jobbnorge.no/en/available...
jobbnorge.no
Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037) | The Norwegian School of Sport Sciences
Job title: Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037), Employer: The Norwegian School of Sport Sciences , Deadline: Wednesday, March 11, 2026
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Professor Adam P. Sharples @profadamsharples.bsky.social · 02/02/2026
Excited to share our Nordic project EMMA has been awarded ≈17M DKK from The Novo Nordisk Foundation We will study how aging reshapes epigenetic “memory” of mitochondrial function in muscle With Tinna Stevnsner & Kristian Vissing Proud to lead key aspects @NIH Norway Position announcement soon!
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Professor Adam P. Sharples @profadamsharples.bsky.social · 15/01/2026
Nice feature in @theatlantic.com by @bonnietsui.bsky.social Our lab’s latest study reveals that skeletal muscle doesn’t just remember growth- it also remembers inactivity. Repeated disuse leaves a molecular imprint that shapes future responses. www.theatlantic.com/health/2026/...
theatlantic.com
A Different Type of ‘Muscle Memory’
Repeated exercise, or wasting, can change the way key genes work.
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Professor Adam P. Sharples @profadamsharples.bsky.social · 06/11/2025
Nice new data from @DrMikeRoberts team! Proteomic profiling of skeletal muscle ribosomes from higher versus lower responders to 10 weeks of resistance training doi.org/10.1101/2025...
doi.org
Proteomic profiling of skeletal muscle ribosomes from higher versus lower responders to 10 weeks of resistance training
Ribosome biogenesis is a key driver of resistance training (RT)-induced skeletal muscle hypertrophy in humans. However, high resolution insight into RT-induced compositional alterations in ribosomes r...
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Professor Adam P. Sharples @profadamsharples.bsky.social · 06/11/2025
New @biorxivpreprint.bsky.social Exercise training improves sarcopenic muscle function via restoration of mitochondrial quality control doi.org/10.1101/2025...
doi.org
Exercise training improves sarcopenic muscle function via restoration of mitochondrial quality control
Mitophagy is an essential component of the mitochondrial quality control program, maintaining mitochondrial homeostasis in metabolic tissues such as skeletal muscle. With age, it is thought that mitoc...
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Professor Adam P. Sharples @profadamsharples.bsky.social · 31/10/2025
First post on Blue Sky New pre-print! Does muscle remember disuse muscle wasting? Our new study shows skeletal muscle retains a molecular memory of disuse! Young muscle shows transcriptional resilience to repeated atrophy. Aged muscle shows exaggerated susceptibility. doi.org/10.1101/2025...
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Kevin Murach @kevinmurachphd.bsky.social · 30/10/2025
A heavy lift from a literal strongman, PhD candidate PJ Koopmans “The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus” 💪🏻 www.biorxiv.org/content/10.1...
biorxiv.org
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Dave Hughes @hughesdc-muscle.bsky.social · 18/10/2025
Played a small part in this project, but there some really interesting and cool findings from the Sharples Lab here. Focus on the memory of repeat muscle atrophy in human skeletal muscle 💪
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