Recent studies have highlighted major roles for skeletal muscle in human health, yet most of the underlying mechanisms remain to be explored, from molecules to the organism. This EMBO Workshop will a…

The Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more...

Using live-imaging in vivo and ex vivo, Sarde et al. show that dystrophic muscle stem cells have precocious differentiation through symmetric divisions and impaired migration, with differential impact...

Using live-imaging in vivo and ex vivo, Sarde et al. show that dystrophic muscle stem cells have precocious differentiation through symmetric divisions and impaired migration, with differential impact...

Postpartum breast cancer is diagnosed five to ten years after giving birth. It is associated with a higher risk of metastasis and a lower survival rate compared with women who have not been pregnant o...

Using live-imaging in vivo and ex vivo, Sarde et al. show that dystrophic muscle stem cells have precocious differentiation through symmetric divisions and impaired migration, with differential impact...

Generation and characterization of a conditional dystrophin (Dmd) knockout mouse reveals myofiber-specific requirements for muscle homeostasis, and an essential role for Purkinje neuron Dmd in neurobe...

In this manuscript, Sacco, Caputo, and colleagues demonstrate that modulation of the JAK2/STAT3 signaling pathway during in vitro myogenic differentiation promotes expansion of PAX7+ SMPCs in multiple...

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...

The extracellular matrix (ECM) niche regulates skeletal muscle stem cell (MuSC) behavior. Using transcriptomic data and 3D imaging, they show that quiescent MuSCs express unique ECM markers, including...

Freire-Delgado and Brunet discover a new mode of cell motility in choanoflagellates, the closest relatives of animals. Under mild confinement, choanoflagellate move over surfaces without cell deformat...

Hibernating brown bears, due to a drastic reduction in metabolic rate, show only moderate muscle wasting. Here, we evaluate if ATPase activity of resting skeletal muscle myosin can contribute to this ...

French Society on Stem Cell Research (FSSCR)

In the primary report of a phase 1b trial, adeno-associated virus gene therapy with fordadistrogene movaparvovec in patients with Duchenne muscular dystrophy was well tolerated in an ambulatory cohort...

As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are …

Author summary We describe our experience in creating a nationwide core facility offering services in bioimage analysis. This virtual facility federates existing resources scattered across the territo...

Using multiple in vivo mouse models, Rehman and colleagues report that tumor-induced impairments in the muscle vasculature mediated by circulating activin A contribute to cachexia development during c...

Summary: Cell extrusion is a conserved process that leads to seamless expulsion of epithelial cells from tissues. This Cell Science at a Glance describes the functions and underlying mechanisms of cel...