Background Obesity is associated with impaired physical fitness, including physical functional performance and cardiorespiratory fitness, which affect health-related quality of life and mortality. Obj...

Mitochondrial dysfunction has long been associated with insulin resistance, yet the causal relationship in humans remains unresolved. Here, we leveraged individuals carrying the diabetogenic m.3243A>G...

Halofuginone curbs weight gain in mice and pigs.

Selective targeting of mitochondrial oxidative stress mitigates lipid-induced insulin resistance in humans.

Fiorenza et al. reveal selective and dynamic alterations in energy-balance-regulating metabokines and sphingolipids throughout weight loss, weight-loss maintenance, and weight regain in adults with obesity. Weight-loss maintenance elicits distinct remodeling patterns within the FGF21-adiponectin-leptin-sphingolipid axis as compared with weight regain, and these changes are associated with cardiometabolic health outcomes.

Nature Metabolism - This authoritative Perspective lays a foundation for the field of obesity research by comparing commonalities and differences between competing models of obesity pathogenesis...

Selective targeting of mitochondrial oxidative stress mitigates lipid-induced insulin resistance in humans.

Objective: Glucagon-like peptide 1 receptor agonists (e.g. semaglutide) potently induce weight loss and thereby reducing obesity-related complications. However, weight regain occurs when treatment is ...

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