Tang et al. reveal that macrophage-derived itaconate acts as a paracrine inhibitor of adipose tissue thermogenesis by blocking succinate uptake into brown adipose tissue.

The Medical Research Council Mitochondrial Biology Unit (MRC MBU), University of Cambridge, wishes to appoint two post-doctoral Research Associates to join the research group of Prof. Mike Murphy at t...

AbstractAims. Succinate accumulates significantly during myocardial ischaemia, and its rapid oxidation upon reperfusion is a critical driver of ischaemia/r

Anderson et al. demonstrate that the glucokinase activator AZD1656 reduces inflammation and reverses cardiac dysfunction and metabolic remodeling in mice with diabetic cardiomyopathy.

Join us at the Keystone Symposia on Mitochondria Signaling in Physiology and Disease, February 2026, in Keystone, with field leaders!

Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to ...

Atherosclerosis is the leading cause of death worldwide. Here, the authors show that defective vascular smooth muscle cell tafazzin promotes mitochondrial dysfunction and atherosclerosis, highlighting...

Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by the synergy of innate immune activation and metabolic stress. This process is regulated by mTORC2 and involves persis...

PhD Project - Understanding and slowing transverse tubule loss in heart failure at University of Bristol, listed on FindAPhD.com

The Burger Lab Defining the metabolite protein regulome

AbstractAims. Ischemic stroke is increasingly treated by mechanical thrombectomy (MT) with the more rapid and complete reperfusion of the ischemic tissue,

Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc...

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

Metformin may serve as a non-toxic intervention to inhibit mitochondrial metabolism and slow DNMT3A-R882 clonal haematopoiesis expansion, thus delaying or averting progression to acute myeloid le...

Information, Program, Registration, Abstract Submission for the 22nd SFRRI Biennial Meeting

Reverse electron transport is the mechanism behind excess mitochondrial reactive oxygen species in the livers of obese mice, which has implications for developing therapeutics for fatty liver dis...

Central to the development of heart failure with preserved ejection fraction (HFpEF) is the redox disruption of metabolic processes, however, the underlying mechanisms are not fully understood. This s...

CREBBP mutations in B-cell acute lymphoblastic leukemia (B-ALL) are linked to poor prognosis and chemoresistance. Here, the authors show that genetic or pharmacological inactivation of CREBBP sensitiz...

CREBBP mutations in B-cell acute lymphoblastic leukemia (B-ALL) are linked to poor prognosis and chemoresistance. Here, the authors show that genetic or pharmacological inactivation of CREBBP sensitiz...

Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state o...

First-in-class approach to targeting mitochondrial DNA polymerase (POLG) with disease modifying potential across mitochondrial DNA depletion syndromes

O2 sensing by carotid body chemoreceptor cells depends on mitochondrial complex I (MCI) function. In mice with a mutated ND6 subunit, which retains normal forward MCI activity but cannot catalyze rev...

TRAM–LAG1–CLN8 family proteins function as enzymes that remodel cellular phospholipids and expand the membrane lipid diversity.

Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.

Petrovic et al. demonstrate that ergothioneine acts as an alternative substrate for cystathionine gamma-lyase, an H2S-producing enzyme, leading to an increase of protein persulfidation. The persulfida...

Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...