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Antentor “AJ” Hinton Jr

@phdgprotein86.bsky.social
264 followers 250 following 8 posts

Assistant Professor, Molecular Physiology and Biophysics, Vanderbilt University The Hinton Lab utilizes SBF-SEM and FIB-SEM to investigate the molecular mechanisms that regulate molecule transfer and morphology changes between the Mito and ER

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Antentor “AJ” Hinton Jr @phdgprotein86.bsky.social · 04/02/2026
Grateful for an incredible time at #Cardiometabolism in Keystone 🇺🇸
Honored to present our work on DRP1, mitochondrial dynamics, lipid droplets & muscle oxygenation in PAD. @keystonesymposia.bsky.social @bwfund.bsky.social @chanzuckerberg.bsky.social @vanderbilt.edu @vubasicsciences.bsky.social
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Sonya Neal @neal-lab.bsky.social · 04/03/2026
Another preprint is out from the Neal Lab! 🎉 Excited to share the first systematic side-by-side comparison of ERAD Derlin paralogs, revealing distinct cellular functions for Derlin-1, Derlin-2, and Derlin-3. www.biorxiv.org/content/10.6...
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Sonya Neal @neal-lab.bsky.social · 04/03/2026
Although Derlins are core components of ERAD, their paralog-specific roles have remained unclear. By analyzing all three in the same cellular context, we uncover clear non-redundant functions at the cellular level.
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Sonya Neal @neal-lab.bsky.social · 04/03/2026
We reveal Derlin-2 is dominant paralog for ER stress relief & loss of Derlin-2 and Derlin-3 disrupts mitochondrial homeostasis, including: • altered ER–mitochondria contact sites • impaired respiration • defective Ca²⁺ handling Linking ER protein quality control directly to mitochondrial function.
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Sonya Neal @neal-lab.bsky.social · 04/03/2026
Mechanistically, we identify ORMDL3, a regulator of sphingolipid metabolism, as a Derlin-dependent ERAD substrate. Without Derlins → ORMDL3 accumulates and mislocalizes to ER–mitochondria contact sites, driving mitochondrial dysfunction.
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Sonya Neal @neal-lab.bsky.social · 04/03/2026
Why does this matter? ORMDL3 is genetically linked to multiple diseases, including: asthma, inflammatory bowel disease, metabolic disease, and cancer. Our findings suggest ERAD safeguards cellular health by preventing pathological ORMDL3 accumulation.
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Sonya Neal @neal-lab.bsky.social · 04/03/2026
Conceptually, this work expands ERAD beyond misfolded protein clearance. Instead, Derlin-mediated ERAD can act as a spatial and quantity control system that regulates functional ER proteins to preserve organelle communication.
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Sonya Neal @neal-lab.bsky.social · 04/03/2026
Importantly, ORMDL3 is genetically linked to several major diseases, including asthma, inflammatory bowel disease, metabolic disorders, and cancer, highlighting the broader biomedical relevance of this work. This work wouldn't have been possible w/o massive tour de force effort across multiple labs!
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Sonya Neal @neal-lab.bsky.social · 04/03/2026
Congrats to first-author and amazing postdoc from my lab @nicola-scott.bsky.social and special thanks to @phdgprotein86.bsky.social lab, @drohsopretty.bsky.social lab, Dr. Dhanendra Tomar lab, and Dr. Mark Phillips lab!
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Antentor “AJ” Hinton Jr @phdgprotein86.bsky.social · 04/02/2026
Grateful for an incredible time at #Cardiometabolism in Keystone 🇺🇸
Honored to present our work on DRP1, mitochondrial dynamics, lipid droplets & muscle oxygenation in PAD. @keystonesymposia.bsky.social @bwfund.bsky.social @chanzuckerberg.bsky.social @vanderbilt.edu @vubasicsciences.bsky.social
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Krishna Mudumbi @krishnamudumbi.bsky.social · 23/01/2026
Mini golf with @phdgprotein86.bsky.social and Jeeyeon Cha's labs, followed by pizza! Great way to kick off the first lab outing of the year!
8 people sitting at a long table with drinks and menus
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Antentor “AJ” Hinton Jr @phdgprotein86.bsky.social · 01/01/2026
Grateful for an amazing year—mentorship, fellowship, and community. Seeing my mentor, Dr. Gayle Slaughter of BCM, at ABRCMS meant everything. Thankful for friends and colleagues who sharpen me. “Steel sharpens steel.” — Proverbs 27:17 ✨
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Antentor “AJ” Hinton Jr @phdgprotein86.bsky.social · 01/01/2026
Grateful for an amazing year—mentorship, fellowship, and community. Seeing my mentor, Dr. Gayle Slaughter of BCM, at ABRCMS meant everything. Thankful for friends and colleagues who sharpen me. “Steel sharpens steel.” — Proverbs 27:17 ✨
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BioTechniques @biotechniques.bsky.social · 13/11/2025
In the STEM Tea podcast, @phdgprotein86.bsky.social sits down with Lindsey Keith-Vincent, Associate Dean at Louisiana Tech University, to explore her unique model for supporting faculty, mentoring students and fostering a culture of authenticity >>> www.biotechniques.com/podcasts/ste... 🧪
biotechniques.com
STEM Tea | Humans first, professionals second
In this episode, AJ Hinton is joined by Lindsey Keith-Vincent, a first-generation college graduate who is passionate about STEM education.
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Dr. Nathan A Smith @drnathanasmith.bsky.social · 16/12/2025
New preprint: Collaborative Team Science effort: @drnathanasmith.bsky.social & @phdgprotein86.bsky.social #URochesterResearch #VanderbiltResearch www.biorxiv.org/content/10.6...
biorxiv.org
The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease
Mitochondrial contact site and cristae organizing system (MICOS) complexes are critical for maintaining the mitochrondrial architecture, cristae integrity, and organelle communication in neurons. MICO...
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BioTechniques @biotechniques.bsky.social · 24/09/2025
In this STEM Tea episode with @phdgprotein86.bsky.social and Corey Reynolds, learn about the crucial need for more Black scientists in every stage of the scientific process, from student labs to clinical trials >>> www.biotechniques.com/podcasts/ste... 🧪
biotechniques.com
STEM Tea | Working together for better science and better opportunities
In this episode of STEM Tea, Corey Reynolds discusses his journey from academia to industry and how he'd like to see Black science grow.
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BioTechniques @biotechniques.bsky.social · 30/09/2025
What role do HBCUs play in student success? In the latest STEM Tea podcast episode, @phdgprotein86.bsky.social is joined by Haysetta Shuler, an I-O psychology consultant and HBCU supporter. Learn more about creating effective mentorships >>> www.biotechniques.com/podcasts/ste... 🧪
biotechniques.com
STEM Tea | Strengthening HBCUs
In this episode, Haysetta Shuler shares strategies for mentoring, maximizing opportunities, and the vital role of HBCUs in student success.
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BioTechniques @biotechniques.bsky.social · 21/10/2025
In this STEM Tea podcast episode, @phdgprotein86.bsky.social and his guests discuss the importance of STEM education in K-12 schools and how these programs can support and expand students’ career prospects, sense of belonging and scientific exploration >>> www.biotechniques.com/podcasts/ste... 🧪
biotechniques.com
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BioTechniques @biotechniques.bsky.social · 14/10/2025
In the latest STEM Tea podcast episode, @phdgprotein86.bsky.social and @ulisesricoy.bsky.social discuss how intentional learning can shape scientific research as well as mentorship practices >>> www.biotechniques.com/podcasts/ste... 🧪
biotechniques.com
STEM Tea | Being visible as an act of service
STEM Tea | Ulises Ricoy discusses his experiences of working on academic recruitment and how learning can be found everywhere.
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BioTechniques @biotechniques.bsky.social · 10/10/2025
Surviving isn’t enough; underrepresented groups in academia need to thrive. In this STEM Tea episode, @phdgprotein86.bsky.social is joined by @brielleryan.bsky.social and @heydrdukes.bsky.social. Learn why visibility is sometimes the most important step >>> www.biotechniques.com/podcasts/ste... 🧪
biotechniques.com
STEM Tea | Founding Black in Neuro
Brielle Ferguson and Angeline Dukes discuss Black in Neuro, the power of visibility in representation and critical lessons about mentorship.
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Brielle Ferguson @brielleryan.bsky.social · 10/10/2025
Had such a great conversation with @phdgprotein86.bsky.social. It's always great to go down memory lane with @heydrdukes.bsky.social to the early days of @blackinneuro.bsky.social, but listening back also gave me a much-needed reminder of the power of community, especially right now.
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BioTechniques @biotechniques.bsky.social · 16/09/2025
How do we build a more equitable STEM community? 💡 In the latest STEM Tea podcast episode, @phdgprotein86.bsky.social is joined by Alberto "Beto"​ Vasquez from @ucsandiego.bsky.social to discuss mentoring students from underserved communities >>> www.biotechniques.com/podcasts/ste... 🧪
biotechniques.com
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BioTechniques @biotechniques.bsky.social · 19/09/2025
What does it mean to ‘lift while you climb’? 🧗🏾‍♀️ In the latest STEM Tea podcast with @phdgprotein86.bsky.social, Clintoria Williams, co-founder of Black in Physiology, shares her insights on impactful mentorship and leading with your 'why'. Listen here >>> www.biotechniques.com/podcasts/ste... 🧪
biotechniques.com
STEM Tea | Impact and sustainability in mentorship
In this episode, Clintoria Williams shares her journey in mentorship, discusses balancing life and work, and highlights the mission of Black in Physiology.
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allen institute @alleninstitute.org · 19/12/2024
Meet our 2024 cohort of Next Generation Leaders! For the next 3 years, they will network with other rising stars, participate in professional development, and share their ideas for future research directions.
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Sonya Neal @neal-lab.bsky.social · 19/12/2024
Time to celebrate for Neal lab members and @bummpucsd.bsky.social! Everyone delivered amazing talks, workshops and poster presentations at @ascbiology.bsky.social 🎉🎉Until next year!
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Derek Applewhite @applewhitederek.bsky.social · 18/12/2024
@ajdiazphd.bsky.social @stephgupton.bsky.social @channyskye.bsky.social @neal-lab.bsky.social @omqu.bsky.social
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Derek Applewhite @applewhitederek.bsky.social · 18/12/2024
Every year I am reminded of how incredible the Cell Biology community is at ASCB.
A group of cell biologist enjoying themselves at a bar. Close friends reuniting
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Laura M. K. Dassama @lmkdassama.bsky.social · 18/12/2024
Introducing Dr. @jonathanccc-chem.bsky.social, the first PhD from the Dassama Lab! I am very proud of the broad and deep undertakings that formed Jonathan's thesis! Some highlights are in the comments. Many congrats to the doc!!
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 19/12/2024
@cbmoens.bsky.social Welcome! Follow lots of people --that's how this place works!
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Stephanie Gupton @stephgupton.bsky.social · 19/12/2024
24 years later and still the annual ASCB meeting is some of the best science and best reunions of the year. @ascbiology.bsky.social @applewhitederek.bsky.social @omqu.bsky.social @klukasik.bsky.social @chrisho.bsky.social @channyskye.bsky.social
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Samira Musah @stemcellengineer.bsky.social · 19/12/2024
Final #MusahLab publication of 2024 is here, open access! We explore epigenetics in hypertensive nephropathy, a major contributor to kidney disease & rising healthcare cost. Congratulations to PhD students/coauthors Yize Zhang, Hamidreza Arzaghi, Zhehan Ma, & Yasmin Roye! tiny.cc/epigenHN
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Dr. Arnaldo Díaz @ajdiazphd.bsky.social · 18/12/2024
@applewhitederek.bsky.social @cterminiphd.bsky.social @neal-lab.bsky.social @phdgprotein86.bsky.social @omqu.bsky.social @channyskye.bsky.social
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Dr. Arnaldo Díaz @ajdiazphd.bsky.social · 18/12/2024
Blessed with a community of brilliant scientists, pioneering leaders, and committed individuals paving a path for others to follow. May each of you continue to shine brightly; your light is leaving a significant mark.
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Angeline J. Dukes, PhD @heydrdukes.bsky.social · 18/12/2024
My live radio interview on MPR News ✨ www.mprnews.org/episode/2024...
Screenshot of an instagram post by MPR
news that has a photo of Dr. Angeline Dukes smiling with a 30 Under 30 chocolate cake. The headline reads U of M neuroscience assistant professor makes Forbes 30 under 30 list for her work in empowering Black scholars. The post is liked by over 7,000 people.
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Sonya Neal @neal-lab.bsky.social · 18/12/2024
The Wiley Press dinner at #CellBio2024 was impeccable! Thank you EIC Alexander Hutchinson and @phdgprotein86.bsky.social for bringing us all together for an unforgettable night!
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Flora Rutaganira @frutag33.bsky.social · 02/12/2024
As #BlueSci grows, let’s remember to amplify the voices that are historically suppressed and create inclusive spaces. I’ve created two lists for you to find Black Scientists here: bsky.app/profile/did:... bsky.app/profile/did:... I’m happy to promote more, just comment!
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Flora Rutaganira @frutag33.bsky.social · 17/12/2024
Dr. AJ Hinton, inter-organelle (mitochondria+ER) molecular communication expert, faculty at Vandy, and creator of the 1000 Inspiring Black Scientists list is now on BlueSky @phdgprotein86.bsky.social. Follow for the latest research in his lab and stay inspired!
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Hanieh Falahati @haniehfalahati.bsky.social · 16/12/2024
This #EM_Monday, is the follow-up of something I posted before on the other place. I posted about these axon curling their way into other pre-synapse, forming funny spinules. This was from mouse visual cortex (www.microns-explorer.org), and not super common.
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Chrystal Starbird @drstarbird.bsky.social · 14/12/2024
New or incoming faculty? Please come join us for a panel tomorrow at #CellBio2024 It’s in the same room as the Mentoring Keynote, which is sure to be amazing. Come to hear about best mentoring practices and stay for the panel!
Panel starts at 9:30 am on December 14th in Room 25B
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 14/12/2024
@maikbischoff.bsky.social ^^^^^
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Dr. Jaye Gardiner @jayeperview.bsky.social · 14/12/2024
Love that it’s in the same room as the mentoring keynote 🙌🏾
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 14/12/2024
This looks like a great opportunity to learn key skills from folks who just made this transition #CellBio2024
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Samira Musah @stemcellengineer.bsky.social · 23/11/2024
Excited to share this TEDx talk by #MusahLab undergrad researcher and recent Duke graduate, Sophia Leeman! She dives into our work using stem cells to engineer patient-specific preclinical models, helping to uncover disease mechanisms and new and safe therapeutics. www.youtube.com/watch?v=Iskr...
TEDx talk by an inspiring #MusahLab undergrad researcher and recent Duke BME & CS graduate, Sophia Leeman! She dives into some of our lab's work using stem cell derivatives to engineer patient-specific preclinical models, helping us uncover disease mechanisms and identify new and safe therapeutics.
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Dr. Jaye Gardiner @jayeperview.bsky.social · 13/12/2024
Hello San Diego!! Excited to be here for #CellBio2024! I’m co-chairing 2 sessions and have a poster - and after the science and art session, I’ll be at the #SciArt show! Come learn about my science, @thegardinerlab.bsky.social plans & opportunities, and my #SciComm #comics!
Photo of San Diego as the plane descends to landScreenshot that reads:

What’s next: Cell Biology from the ASCB MOSAIC Scholars

Location: Room 31B
Date: Monday, Dec 16 8:45 am
Duration: 1 hour 30 minutesScreenshot that reads:

Science and Art: Bridging Two Creative Universes

Location: Room 33B
Date: Tuesday, Dec 17 5:00 pm
Duration: 1 hour 30 minutesScreen shot that reads:

P2531 Role of the BAF Complex in Pancreatic Cancer-Associated Fibroblast Function [Board No. B139]

Session Posters: ECM Interaction
Location: Exhibit Halls D-G
Date: Tuesday, Dec 17 11:15 AM
Duration: 1 hour 30 minutes
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Antentor “AJ” Hinton Jr @phdgprotein86.bsky.social · 15/12/2024
I’m here ! It took a while! Still love all the same things 😎😁
All eight shapes of mitochondria Reconstruction of mitochondria from
Confocal imaging of human cells Mitotracker staining (orange) and nucleus (green)  in Hela cells
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Chrystal Starbird @drstarbird.bsky.social · 15/12/2024
Welcome to 🦋 Dr. Hinton! @phdgprotein86.bsky.social
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Daniel Gonzales @dgonzales1990.bsky.social · 14/12/2024
Really sorry for letting y’all down. Full details here
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American Society for Cell Biology @ascbiology.bsky.social · 14/12/2024
ASCB President Sandra Murray with our 2024 Mentoring Keynote, Sonya Neal, Associate Professor, HHMI Freeman Hrabowski Scholar, UC San Diego, HHMI #CellBio2024
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Sonya Neal @neal-lab.bsky.social · 14/12/2024
Holding back tears all throughout the morning while delivering the Mentoring Keynote. It was more moving than anything to be in a room full of trailblazers in academia. Thank you @ASCBiology for this amazing recognition♥️♥️♥️
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Krishna Mudumbi @krishnamudumbi.bsky.social · 02/12/2024
The Mudumbi Lab website is live! lab.vanderbilt.edu/mudumbi-lab/ We are interested in the kinetics of RTK mediated signal transduction and will be using a number of advanced live cell image approaches to study this. If you're interested in RTKs like EGFR, and 🔬 reach out!
lab.vanderbilt.edu
Home
Welcome! The kinetics of receptor tyrosine kinase (RTK) signaling The Mudumbi lab is fundamentally interested in the mechanistic underpinnings of signal transduction by cell surface transmembrane rece...
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