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Maximilian Kleinert

@mkleinert.bsky.social
412 followers 431 following 5 posts

Researcher interested in metabolism, nutrition, energy balance. Head of Molecular Physiology of Exercise and Nutrition Department @Leibniz_Dife. Views are my own.

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Reposted by Maximilian Kleinert
Deutsches Zentrum für Diabetesforschung (DZD) @diabresearch-dzd.bsky.social · 21/01/2025
🚨Paper Alert 🚨: PanK4 Identified as Regulator of Glucose and Lipid #Metabolism. A new study led by mkleinert.bsky.social‬ at our DZD-Partner #DIfE has identified PanK4 as a key regulator of energy metabolism in skeletal muscle. ⬇️ ⬇️ ⬇️ ⬇️
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Reposted by Maximilian Kleinert
Alexander Bartelt @barteltlab.bsky.social · 19/01/2025
Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing! 👇 www.cell.com/cell-reports...
Islet from aged mouse vs islet from young mice after 10 weeks of IF - IHC for Nkx6.1
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Reposted by Maximilian Kleinert
Pablo Ranea-Robles @pranea.bsky.social · 12/01/2025
Our new paper from @clemmensenc.bsky.social @metabolcenter.bsky.social is available online! I briefly summarize here our findings on the effects of short-term overfeeding in mice! We show real time energy expenditure data during and after overfeeding! diabetesjournals.org/diabetes/art... 🧵 (1/n)
diabetesjournals.org
Time-resolved effects of short-term overfeeding on energy balance in mice
To curb the obesity epidemic, it is imperative that we improve our understanding of the mechanisms controlling fat mass and body weight regulation. While g
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Reposted by Maximilian Kleinert
Craig A. Goodman @craigagoodman1.bsky.social · 09/01/2025
Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail physoc.onlinelibrary.wiley.com/doi/10.14814...
physoc.onlinelibrary.wiley.com
Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail
While total RNA concentrations putatively represent ribosome content, there is a need to homologize various quantification approaches. Thus, total RNA concentrations ([RNA]) provided through UV–Vis s...
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Maximilian Kleinert @mkleinert.bsky.social · 08/01/2025
Shamelessly😬 reposting our recent work to a broader metabolism network—thanks to @frezzalab.bsky.social starter packs. We’d love to hear your thoughts!
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Reposted by Maximilian Kleinert
Christian Frezza @frezzalab.bsky.social · 07/01/2025
With two complete starter packs (in my profile), here is a 3rd one for the ever-growing metabolism community. Please contact me if you are working (prerequisite) on metabolism and want to be included here; there is still some space. I will keep updating it. go.bsky.app/7Uwa6fb
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Reposted by Maximilian Kleinert
Agingdoc⭐David Barzilai🔔MD PhD, MS, MBA, DipABLM @agingdoc.bsky.social · 06/01/2025
Why Is the American Diet So Deadly? A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity. @DhruvKhullar www.newyorker.com/magazine/202...
newyorker.com
Why Is the American Diet So Deadly?
A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity.
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Reposted by Maximilian Kleinert
Trends in Endocrinology and Metabolism @cp-trendsendomet.bsky.social · 06/01/2025
NEW ISSUE! We start 2025 approaching gut-brain crosstalk from a variety of perspectives, including neuroendocrine regulation of gut-brain signaling, interaction between microbiome and circadian rhythms, microbial metabolites associated with gut health and the potential of microbiome-based therapies.
The cover depicts gut-brain communication as sand in an hourglass, highlighting its circadian component. Cover credits: Cristina Cuesta Martí.
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Reposted by Maximilian Kleinert
Kevin Murach @kevinmurachphd.bsky.social · 06/01/2025
A really nice special issue in @jphysiol.bsky.social by Dr. Chris Sundberg “Physiology of ageing skeletal muscle and the protective effects of exercise” feat. some work by our lab and many others! Check it out @myoblue.bsky.social physoc.onlinelibrary.wiley.com/toc/14697793...
physoc.onlinelibrary.wiley.com
Special Issue: Physiology of ageing skeletal muscle and the protective effects of exercise: The Journal of Physiology: Vol 603, No 1
<em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.
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Maximilian Kleinert @mkleinert.bsky.social · 06/01/2025
Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue
nature.com
Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications
Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
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