Dicer has long been viewed as the RNAse III enzyme that generates small regulatory RNAs to drive RNA interference (RNAi) machinery and posttranscriptional gene silencing. However, a growing body of ev...

The Larry Sandler Award was established in 1988 by the colleagues, friends, and students of Dr. Larry Sandler after his untimely death in 1987. The award serves to honor Dr. Sandler for his many contr...

When preparing a scientific paper, we typically write with coauthors who have different backgrounds and styles, and we target readers who have little time and patience. To help both readers and writer...

The prothoracic gland is the principal steroidogenic gland in Drosophila. Here Zhang et al. perform transcriptomic analysis and show that starvation prior to the nutrient restriction checkpoint alters...

How does transcriptional patterning regulate salivary gland morphogenesis? In this study, the authors provide a detailed scRNA-seq characterization of transcriptional changes during early morphogenesi...

Adult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...

The pace of embryonic development differs between mammalian species, yet the molecular basis for this remains unknown. By comparing protein dynamics i…

Sorge et al. use a co-optimization strategy to design a chemically defined (holidic) diet tailored for fast Drosophila development. This has broad applications in nutritional and metabolic studies.

Intercellular calcium waves (ICWs) coordinate multicellular responses, although precise mechanisms are less understood. Here, authors show that nutrient-triggered hormone release from the brain stimul...

Cellular differentiation and morphogenesis require the coordination between cytoskeletal remodeling and transcriptional programs, raising the question…

Pericentromeric heterochromatin clusters into nuclear foci known as chromocenters, the proteome of which remains largely unknown. This study uses quantitative mass spectrometry to characterize the chr...

Molecular biology; Cell biology

Wg/Wnt signalling—a highly conserved transduction pathway—has most commonly been found to be involved in patterning, cell fate, or cell proliferation, but less so in shaping organs or body parts. A re...

The ARP2/3 complex works together with actomyosin in an oscillatory program at the soma to govern neuronal polarization.

Neurons must establish distinct microtubule orientations in axons vs. dendrites. Yagoubat and Conduit reveal that asymmetric microtubule nucleation from oriented Golgi stacks within the cell body help...

Thakur et al. find that the lipid transfer protein PDZD8 induces synaptic growth. Through in vivo studies, the authors find that PDZD8 functions at neuronal ER-late endosome/lysosome membrane contact ...

IU Biology news: The IU Stock Center maintains thousands of documented, living genetic strains of Drosophila melanogaster, a small fruit fly that has served as one of science’s most powerful tools for...

The authors identify glucose-derived conversion of citrate to acetyl-CoA upstream of histone acetylation as modulating the regional dynamics of oligodendrocyte progenitors, with extranuclear acetyl-Co...

ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.

Yu, Li and colleagues explore the metabolome of neurons, microglia and astrocytes under normal, ageing and Alzheimer’s disease conditions. They find enrichment of glutathione and polyamine metabolism ...

Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K...

Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...

This Perspective discusses the mechanisms underlying both the formation and scission of caveolae, with a focus on highlighting the role of specific lipids in regulating and coupling these processes.