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Yale School of Medicine

@yaleschoolofmed.bsky.social
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Yale School of Medicine @yaleschoolofmed.bsky.social · 28/09/2026
A YSM study published in Nature found that genetic background significantly influenced cancer susceptibility, tumor latency, and types of mutations driving cancer progression. Findings suggest prevention and treatment strategies should consdier genetics: pubmed.ncbi.nlm.nih.gov/42486977/ @nature.com
pubmed.ncbi.nlm.nih.gov
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Yale School of Medicine @yaleschoolofmed.bsky.social · 21/09/2026
A YSM study published in @science.org suggests that 4H2 could be developed as a dual-purpose therapy: a tool for cancer immunotherapy and a vehicle for delivering RNA-based treatments. Authors say this may open avenues for therapies for conditions beyond cancer. medicine.yale.edu/publication-...
medicine.yale.edu
Lupus Autoantibody Activates Tumor Immunity and Delivers RNA
This study investigates a lupus-derived autoantibody's ability to activate tumor immunity via intracellular RNA-binding and cGAS activation, improving
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Yale School of Medicine @yaleschoolofmed.bsky.social · 18/09/2026
A YSM study published in the Journal of General Internal Medicine reports Black and Hispanic individuals are significantly less likely than non-Hispanic white individuals to receive a timely dementia diagnosis. Authors suggest targeted interventions could help: bit.ly/4Agkpq1 @journalgim.bsky.social
bit.ly
Associations of Individual, Neighborhood-Level, Racial, and Ethnic Factors in Timely Dementia Diagnosis
This study investigates racial disparities in timely dementia diagnosis, showing education and neighborhood affluence significantly contribute to delays,
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Yale School of Medicine @yaleschoolofmed.bsky.social · 17/09/2026
A YSM study in JAMA Psychiatry reports the neuroplastogen TSND-201 is a promising treatment for PTSD, offering rapid and durable symptom relief with minimal side effects. medicine.yale.edu/publication-...
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Yale School of Medicine @yaleschoolofmed.bsky.social · 16/09/2026
Writing in JAMA Oncology, YSM researchers report that prostate-specific membrane antigen positron emission tomography (PSMA-PET) #imaging could shift #prostate #cancer treatment patterns by detecting previously hidden metastases. @jamaoncology.com Learn more: medicine.yale.edu/publication-...
Initial Prostate Cancer Therapy by Initial Staging Imaging Modality
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Yale School of Medicine @yaleschoolofmed.bsky.social · 15/09/2026
A YSM #study in Cell Press Blue investigates how #rhinoviruses (RVs), which cause the common cold and respiratory issues, trigger varying #immune responses in the nasal epithelium, the tissue lining the nose: medicine.yale.edu/publication-...
Antibodies bind to a rhinovirus.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 14/09/2026
Writing in Molecular Omics, YSM researchers report that molecular variation in #pancreatic ductal #adenocarcinomas comes mostly from cell line identity, with relatively little variation explained by the identity of KRAS #mutations. @molecularomics.bsky.social medicine.yale.edu/publication-...
Pancreatic cells in culture expressing mutant KRAS and a green fluorescent protein.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 11/09/2026
A YSM study investigates how serial #cardiovascular magnetic resonance imaging ( #MRI ) helps predict adverse cardiovascular events in #immune checkpoint inhibitor myocarditis, highlighting its potential to improve risk stratification. medicine.yale.edu/publication-...
Prospective Serial Cardiovascular MRI of Immune Checkpoint Inhibitor Myocarditis
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Yale School of Medicine @yaleschoolofmed.bsky.social · 10/09/2026
People who use smokable #drugs account for 53.6% of burn-related #hospital encounters, despite making up only 14.8% of the #Medicaid population, a YSM team finds in a JAMA Internal Medicine study. Researchers say butane torches are a major risk factor: medicine.yale.edu/publication-... @jama.com
medicine.yale.edu
Burn Risks Linked to Butane Torches in Smokable Drug Use
This study investigates burn risks among people who use smokable drugs, highlighting an urgent public health concern.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 09/09/2026
In a study published in JAMA Internal Medicine, YSM researchers found significant variation in commercial payer-negotiated #costs for outpatient #PhysicalTherapy (PT) services across U.S. #hospitals: medicine.yale.edu/publication-... @jama.com
medicine.yale.edu
Price Variation in US Outpatient Physical Therapy Services
This study investigates price variation for outpatient physical therapy services, finding significant cost differences between hospitals and highlighting
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Yale School of Medicine @yaleschoolofmed.bsky.social · 08/09/2026
A YSM study published in #Arthritis Care & Research finds monitoring of #hydroxychloroquine blood levels could improve disease control in systemic #lupus erythematosus through personalized dosing adjustments: medicine.yale.edu/publication-... @acr-journals.bsky.social
Pill bottles full of hydroxychloroquine tablets.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 03/09/2026
A recent YSM study, published in Cell by Cell Press, identifies distinct purposes for two different types of #neurons in the heart's intrinsic nervous system. Learn more about how the "little #brain on the #heart" helps maintain cardiac function: bit.ly/4wYtH73 @cellpress.bsky.social
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Yale School of Medicine @yaleschoolofmed.bsky.social · 03/09/2026
A YSM study published in JAMA Network Open finds that red #blood cell exchange transfusion (ET) significantly improves clinical outcomes for adults #hospitalized with severe #babesiosis: medicine.yale.edu/publication-... @jama.com
Red blood cells in a blood vessel.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 02/09/2026
A YSM study published in JMIR Medical Education finds #AI ambient scribes can complement #medical student documentation without significantly affecting note quality or #clinical reasoning: medicine.yale.edu/publication-... @jmirpub.bsky.social
Medical students speak with a patient in an exam room.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 01/09/2026
A YSM study published in Cancer Discovery suggests dietary #fat composition could be a modifiable risk factor for #pancreatic ductal adenocarcinoma (PDAC), a highly lethal form of #cancer. @aacrjournals.bsky.social medicine.yale.edu/publication-...
A 3D image of human bowels highlights the location of the pancreas.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 31/08/2026
A YSM study published in @ajpmonline.bsky.social finds living in a neighborhood with visible signs of disorder increases the risk of #dementia and other forms of #cognitive impairment. Learn more: medicine.yale.edu/publication-...
medicine.yale.edu
Neighborhood Disorder Linked to Higher Dementia Risk
This study investigates how neighborhood disorder increases dementia risk, finding cardiometabolic health partially mediates this link, suggesting community
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Yale School of Medicine @yaleschoolofmed.bsky.social · 28/08/2026
In a new Yale-led study, 90% of K-12 school nurses reported their school stocked #naloxone to treat #opioid #overdose – but researchers report storage and administration restrictions could slow response times during emergencies: medicine.yale.edu/publication-... @journals.sagepub.com
A doctor holds Nyxoid, a naloxone nasal spray used for emergency opioid overdose reversal.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 27/08/2026
Writing in @jama.com #JAMA Internal Medicine, YSM researchers investigate the prevalence of high-risk #prescriptions among older adults discharged from emergency departments (EDs) and suggest standardized interventions could guide safer #medication choices: medicine.yale.edu/publication-...
medicine.yale.edu
High-Risk Medication Prescriptions in Older Adults Post-ED
This study investigates high-risk medication prescribing for older adults discharged from emergency departments, showing 6.5% receive potentially inappropriate
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Yale School of Medicine @yaleschoolofmed.bsky.social · 26/08/2026
A YSM study published in Community Mental Health Journal investigates the link between #arrest history and #suicide risks, finding recently arrested individuals face higher rates of suicidal thoughts, plans, and attempts: medicine.yale.edu/publication-...
medicine.yale.edu
Arrests Linked to Higher Suicide Risks: Social Factors Examined
This study investigates the link between arrest history and suicide risks, finding recently arrested individuals face higher rates of suicidal thoughts, plans,
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Yale School of Medicine @yaleschoolofmed.bsky.social · 25/08/2026
A YSM study printed in the journal Urology investigates the #gender #PayGap in academic #urology, reporting projected career earnings deficits nearing $1 million for American #women: medicine.yale.edu/publication-...
medicine.yale.edu
Gender Pay Gap in Academic Urology: $1M Lifetime Deficit
This study investigates differences in pay in academic urology, showing women earn less than men across ranks, with projected career earnings deficits nearing
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Yale School of Medicine @yaleschoolofmed.bsky.social · 24/08/2026
Writing in Blood Advances, Layla Van Doren, MD, and colleagues report increased #burnout among #physicians focused on #SickleCell disease (SCD) compared to their non-SCD-focused peers. medicine.yale.edu/publication-... @bloodjournals.hematology.org
Layla Van Doren, MD, speaks with a colleague at Yale New Haven Hospital.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 21/08/2026
In a Phase II #ClinicalTrial, YSM researchers find sacituzumab govitecan, a Trop-2–directed antibody-drug conjugate, could be an effective treatment option for patients with recurrent endometrial #cancer, including those with aggressive #tumor subtypes. @aacrjournals.bsky.social
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Yale School of Medicine @yaleschoolofmed.bsky.social · 20/08/2026
Writing in @jrheumatol.bsky.social, YSM researchers have developed & tested a novel imaging metric for measuring calcinosis cutis (CC) in patients with systemic #sclerosis (SSc). The new tool could improve clinical assessment and enable personalized treatment: medicine.yale.edu/publication-...
medicine.yale.edu
Novel Imaging Metric Tracks Calcinosis Cutis Changes in SSc
This study investigates the scleroderma calcinosis cutis score (SC2S), a reproducible imaging metric to quantify lesion volume changes during treatment for
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Yale School of Medicine @yaleschoolofmed.bsky.social · 19/08/2026
A YSM study compares the cost-effectiveness of haploidentical stem cell transplantation for sickle cell disease offers better value in terms of quality-adjusted life years than gene therapy or standard care: medicine.yale.edu/publication-... @bloodjournals.hematology.org @bloodjournal.bsky.social
Sickle Cell Anemia Red cells in Blood Stream - stock illustration
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Yale School of Medicine @yaleschoolofmed.bsky.social · 18/08/2026
Writing in @nejm.org, a YSM team reports an all-oral regimen of decitabine–cedazuridine plus venetoclax is a viable #treatment option for older patients with acute myeloid #leukemia: medicine.yale.edu/publication-...
Overall Survival with oral decitabine–cedazuridine in patients with AML
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Yale School of Medicine @yaleschoolofmed.bsky.social · 17/08/2026
YSM researchers examine in a new #study how colorectal #cancer (CRC) screening trends changed in the United States during the COVID-19 #pandemic, uncovering the impact of racial and ethnic differences as well as new screening methods: medicine.yale.edu/publication-...
A chart follows pandemic-era trends in colorectal screening recommendations.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 07/08/2026
A YSM team has investigated the limitations of circulating #tumor #DNA (ctDNA) surveillance in detecting peritoneal metastases (PM) in patients with stage II–III colon #cancer: medicine.yale.edu/publication-...
medicine.yale.edu
Peritoneal Metastases Evade Circulating Tumor DNA Detection
This study investigates the limitations of circulating tumor DNA (ctDNA) surveillance in stage II–III colon cancer, showing reduced detection of isolated
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Yale School of Medicine @yaleschoolofmed.bsky.social · 06/08/2026
Writing in the journal Cancer Letters, a YSM team explores the role of Homeobox (HOX) gene expression patterns, known as the #HOXCode, to help understand the #evolution of individual #cancers. Learn more: medicine.yale.edu/publication-...
medicine.yale.edu
HOX Codes and RUNX1T1: Unveiling Lineage Plasticity in Cancer
This study investigates how HOX gene expression patterns identify therapy-resistant cancer subtypes and demonstrates RUNX1T1-HDAC3 inhibition as a potential
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Yale School of Medicine @yaleschoolofmed.bsky.social · 05/08/2026
A YSM team recently investigated the potential of a #lupus-associated autoantibody, called 4H2, to activate #tumor immunity and deliver #RNA into cells. Their results are published in Science Signaling: medicine.yale.edu/publication-.... @science.org
medicine.yale.edu
Lupus Autoantibody Activates Tumor Immunity and Delivers RNA
This study investigates a lupus-derived autoantibody's ability to activate tumor immunity via intracellular RNA-binding and cGAS activation, improving
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Yale School of Medicine @yaleschoolofmed.bsky.social · 04/08/2026
YSM researchers evaluate amivantamab as a targeted therapy for recurrent or metastatic head and neck squamous cell #carcinoma (HNSCC), in a recent Journal of Clinical Oncology study: medicine.yale.edu/publication-...
A clinical figure displaying topline results from a journal study on amivantamab.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 03/08/2026
YSM #researchers develop a video-based decision aid designed for older women considering breast #cancer screening beyond age 74, in a recent study published in the Journal of the American #Geriatrics Society. Learn more: medicine.yale.edu/publication-...
A doctor looks at a breast scan, while in the background a patient is seen using a mammography machine.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 31/07/2026
In a recent #study published in the Journal of the National Cancer Institute, YSM researchers report a high prevalence of financial #ConflictsOfInterest (FCOI) across multiple sectors of the United States #cancer ecosystem. Learn more: medicine.yale.edu/publication-...
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Yale School of Medicine @yaleschoolofmed.bsky.social · 30/07/2026
In a Journal of Hepatology review, YSM researchers explore how #AI can enhance diagnosis, prognosis, and treatment of #liver #cancer by analyzing complex, multimodal datasets. Learn more: medicine.yale.edu/publication-... @jhepatology.bsky.social
Example imaging-based artificial intelligence-aided workflow across the hepatocellular carcinoma care continuum
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Yale School of Medicine @yaleschoolofmed.bsky.social · 29/07/2026
A weeklong prophylactic course of #antibiotics following #JointReplacement #surgery fails to significantly prevent infection or complication rates, YSM researchers report in a recent Journal of Arthroplasty study: medicine.yale.edu/publication-...
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Yale School of Medicine @yaleschoolofmed.bsky.social · 28/07/2026
A novel mucosal adjuvant created by YSM researchers helps boost #immunity vs genital #herpes, in a new study published in Science Immunology: medicine.yale.edu/publication-... @science.org
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Yale School of Medicine @yaleschoolofmed.bsky.social · 27/07/2026
In a new @nature.com study, YSM researchers examine how inherited #genetics influence the progression and evolution of #liver #cancer. Learn more and find the full study: medicine.yale.edu/publication-...
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Yale School of Medicine @yaleschoolofmed.bsky.social · 24/07/2026
3D multi-omics #tumor atlases have the potential to revolutionize #cancer detection & #treatment, researchers find in a new review published in Nature Cancer Reviews. @natureportfolio.nature.com Learn more: medicine.yale.edu/publication-...
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Yale School of Medicine @yaleschoolofmed.bsky.social · 23/07/2026
In a new study, YSM researchers examine the impact of differentiated service delivery (#DSD) models versus conventional care on #tuberculosis preventive therapy (TPT) outcomes among people living with #HIV (PLHIV) in sub-Saharan Africa. Learn more: medicine.yale.edu/publication-...
medicine.yale.edu
HIV Care Models and Tuberculosis Prevention in Africa
This study found that differentiated HIV care models—community-based approaches to HIV care that have gained popularity in sub-Saharan Africa—achieved similar
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Yale School of Medicine @yaleschoolofmed.bsky.social · 22/07/2026
In a new @nature.com Nature Communications study, YSM researchers take a closer look at data memorization in #LLMs adapted for #medical use, discovering benefits to model performance along with some risks to generalization and #privacy. medicine.yale.edu/publication-...
medicine.yale.edu
What Medical Large Language Models Remember: Benefits, Risks, and Recommendations
This study systematically examined what large language models memorize when adapted for medicine, how frequently memorization occurs, how much content is
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Yale School of Medicine @yaleschoolofmed.bsky.social · 21/07/2026
Writing in @science.org Science Advances, YSM researchers explore how two related #proteins, YAP and TAZ, influence liver cell growth and #immune responses. Results highlight both proteins as independent drivers of cell behavior and immune interactions in #cancer: medicine.yale.edu/publication-...
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Yale School of Medicine @yaleschoolofmed.bsky.social · 20/07/2026
In a new study in the Journal of Political Economy, YSM researchers explore the multigenerational effects of early-life #social environments in rhesus #monkeys, with implications for human #development. medicine.yale.edu/publication-...
medicine.yale.edu
Multigenerational Effects of Early-Life Advantage in Monkeys
This study investigates how early-life advantages in rhesus monkeys influence health and social status across generations, showing benefits persist only for
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Yale School of Medicine @yaleschoolofmed.bsky.social · 17/07/2026
A new study evaluates whether digital #breast tomosynthesis offers advantages over conventional digital #mammography in detecting favorable #tumor characteristics, such as smaller size, lower grade, and absence of lymph node involvement, in women aged 75 and older: medicine.yale.edu/publication-...
medicine.yale.edu
Tomosynthesis vs Conventional Mammography: Breast Cancer Detection in the Elderly
This study investigates the benefits of digital breast tomosynthesis over conventional mammography in older women, showing limited advantage in detecting
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Yale School of Medicine @yaleschoolofmed.bsky.social · 16/07/2026
A YSM study in @natureportfolio.nature.com's npj Precision Oncology analyzes the impact of specific #genetic #mutations on the prognosis of patients with pleural and peritoneal mesothelioma, rare and aggressive #cancers affecting the lungs and abdomen, respectively. medicine.yale.edu/publication-...
medicine.yale.edu
Prognostic Role of NF2 and TERT Mutations in Mesothelioma
This study investigates the prognostic impact of somatic mutations in mesothelioma, showing NF2 truncating variants worsen survival, supporting genomic testing
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Yale School of Medicine @yaleschoolofmed.bsky.social · 15/07/2026
Writing in Clinical Cancer Research from @aacrjournals.bsky.social, a YSM team evaluates whether combination therapy with osimertinib + gefitinib could improve outcomes for some patients whose non small cell lung cancer has become resistant to osimertinib. medicine.yale.edu/publication-...
medicine.yale.edu
Osimertinib-Gefitinib Combo Shows Modest Benefits in EGFR NSCLC
This study investigates combining osimertinib and gefitinib in advanced lung cancer with EGFR C797S mutation, showing modest benefits but highlighting tumor
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Yale School of Medicine @yaleschoolofmed.bsky.social · 10/07/2026
Writing in @nature.com Nature Biotechnology, YSM #researchers introduce Perturb-DBiT, a novel method for spatially resolved #CRISPR screening in complex tissue environments. medicine.yale.edu/publication-...
A CODEX UMAP revealing 16 unique clusters in a syngeneic lung model schematic.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 01/07/2026
A new YSM study develops a precise and efficient method for synthesizing engineered circular RNAs (circRNAs), which hold significant potential for advancing RNA-based therapeutics for conditions including infectious #diseases and #cancer. Learn more: medicine.yale.edu/publication-...
medicine.yale.edu
Precise Engineered circRNAs via Enzymatic Ligation Method
This study demonstrates a method to produce highly stable, precise circular RNAs for therapeutic or research use by optimizing enzymatic ligation and RNA
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Yale School of Medicine @yaleschoolofmed.bsky.social · 22/06/2026
In a recent study, YSM researchers investigate how PI3K enables #pancreatic #cancer cells to resist KRAS inhibitors by activating wild-type RAS signaling, suggesting combined PI3K-KRAS targeting as a #therapeutic strategy. Learn more: medicine.yale.edu/publication-...
A clinician's hands hold a 3D representation of a pancreas.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 17/06/2026
A new YSM-led study shows how dietary #fat composition shapes #pancreatic #cancer risk. The results are published in Cancer Discovery: medicine.yale.edu/publication-...
A computer generated model of a human being's internal organs, with the pancreas highlighted.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 15/06/2026
Writing in @nature.com Nature Genetics, YSM researchers introduce a #DeepLearning #AI tool that can combine and interpret spatial transcriptomics (ST) data from multiple streams. The tool, INSPIRE, could offer more detailed mapping of tissues: medicine.yale.edu/publication-...
A doctor wearing scrubs holds a visual representation of data in an outstretched hand.
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Yale School of Medicine @yaleschoolofmed.bsky.social · 01/05/2025
A YSM study led by Carlos Oliveira, MD, PhD, finds #nirsevimab is effective at preventing severe #RSV disease in infants – but timing matters, since the drug's effectiveness declines over the three months after injection. @jama.com medicine.yale.edu/news-arti...
medicine.yale.edu
Timing of RSV Immunization Matters for Infant Protection
A long-acting monoclonal antibody prevents serious RSV illness in most infants. But timing matters to ensure maximum effectiveness.
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