The lab investigates the molecular mechanisms that control biological timing in mouse and human stem cells (Azzi & Rayon, Curr Opinions 2024; Nakanoh et al., Dev Cell 2026). The central aim of this ex...

Using a combination of microglia-specific conditional mouse knockout and knockin approaches and xenotransplantation of human iPSC-derived microglia, Diaz-Salazar et al. demonstrate that the human-spec...

Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developme…

The pace of embryonic development differs between mammalian species, yet the molecular basis for this remains unknown. By comparing protein dynamics i…

The differentiation variability of human pluripotent stem cell lines is diagnosed and corrected.

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

Xu et al. perform a whole-genome CRISPR-Cas9 knockout screen using directed differentiation systems. They find that MEN1 and SUZ12 modulate human developmental timing by epigenetically controlling biv...

Developmental processes display temporal differences across species, leading to divergence in organ size and composition. In the cerebral cortex, neurons of diverse identities are generated sequential...

Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show rapid progression of transcriptional programs in specific tissues relative to morphological landmarks. This shift in...

International recruitment scheme comes amid announcement of Government principles for 10-year research funding

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

Traditional peer review is slow, often delayed by the time-consuming process of identifying reviewers and lengthy review turnaround times. This study tests the feasibility of the Fast & Fair peer revi...

Friedrich Miescher Institute, open position