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Grosshans Lab

@labgrosshans.bsky.social
494 followers 135 following 58 posts

Studying mechanisms of developmental clocks and timers at the Friedrich Miescher Institute for Biomedical Research, Basel.

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Grosshans Lab @labgrosshans.bsky.social · 09/09/2026
Very proud of Jana 👇 for receiving the 2026 Ed Fischer Prize recognizing the best dissertation at FMI in 2025! And her presentation at the award ceremony at the FMI's Annual Meeting would have merited a separate award for most entertaining/dry-humored talk - wonderful! @fmiscience.bsky.social
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FMI science @fmiscience.bsky.social · 27/08/2026
Looking forward to taking part in the Doctoral Insights Symposium on 10 September and sharing an inside perspective on PhD life at FMI. Join us online for an open conversation about doctoral research in Europe! 👇
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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 26/08/2026
Join the 4th Swiss RNA Therapeutics Summit on 28 January 2027 at the University of Bern. Connect with experts from academia, biotech and pharma and explore the latest developments in RNA-based medicines. 📝 Registration opens soon. More information: www.rnatx.ch #RNA #RNATherapeutics
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Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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Teresa Rayon @trayon.bsky.social · 15/08/2026
Our work on the role of the proteasome in developmental tempo is out!!!! 🐭⌛️👤⏳ Six years after identifying an association between protein stability and developmental tempo, we now demonstrate a causal link between protein turnover and developmental tempo through proteasomal degradation
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Max Heiman @heiman.bsky.social · 16/08/2026
For the last year, aECM Club seminars have brought together researchers working on apical ECM in diverse species and tissues - yeast cell wall, C. elegans cuticle, Drosophila lens, mammalian inner ear and pancreatic lumen, and many others. Sign up for 2026-27: forms.gle/DDJUxGLkcSRb...
forms.gle
aECM Club 2026-27
Dear aECM researchers, Thank you for your interest in aECM Club! Feel free to forward this brief survey to any colleagues and trainees who may be interested.
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David Brückner @davidbrueckner.bsky.social · 10/08/2026
If you're looking for a PhD position, or know someone looking checkout our interdisciplinary PhD Fellowship program! We are always looking for talented students with a physics or computational background to join our group to work on the physics of living systems!
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Grosshans Lab @labgrosshans.bsky.social · 05/08/2026
RNA-binding proteins (RBPs) often bind numerous transcripts - but do they act through a network effect? Our new paper in @plosbiology.org shows that the highly conserved LIN28 RBP controls developmental timing in C. elegans larvae through only two targets. doi.org/10.1371/jour... 1/n
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Grosshans Lab @labgrosshans.bsky.social · 05/08/2026
Tweetorial/thread with some academic details to follow 👇
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FMI science @fmiscience.bsky.social · 03/08/2026
Looking forward to joining the Doctoral Insights Symposium on 10 September and introducing students to the FMI PhD Program, our research, and life in Basel’s vibrant biomedical ecosystem 🧬
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FMI science @fmiscience.bsky.social · 08/07/2026
Much of the genome is made up of repetitive DNA sequences that trace back to ancient mobile elements. Two new studies from the @marcbuhler.bsky.social group, now published in @cp-molcell.bsky.social, show how cells keep these potentially disruptive sequences under control. www.fmi.ch/news-events/...
fmi.ch
How cells keep genomic hitchhikers under control
Much of the genome is made up of repetitive DNA sequences that trace back to ancient mobile elements, many of which have lost their ability to copy themselves into new locations but can still cause pr...
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FMI science @fmiscience.bsky.social · 22/06/2026
Undergraduate or master’s student in the life sciences looking for fully funded PhD programs in Europe? Don’t miss the free @docinsightssymp.bsky.social on Sep 10 at 14:00 CET, featuring 20+ programs across 7 countries, including the FMI International PhD Program. Register: www.doctoralinsights.at
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FMI science @fmiscience.bsky.social · 23/06/2026
We’re delighted to welcome @computingcaitie.bsky.social to the FMI next year! Her work will bring an interdisciplinary perspective spanning structural biology, quantitative imaging and computational analysis to our institute, opening exciting new ways to study ciliary structure and dynamics.
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FMI science @fmiscience.bsky.social · 23/06/2026
Congratulations to FMI senior group leader Jeff Chao and his team for being awarded €2.5 million through the @erc.europa.eu Advanced Grant scheme to study how RNA controls gene expression in living cells, with the goal of uncovering fundamental principles of RNA biology. www.fmi.ch/news-events/...
fmi.ch
Jeff Chao’s group awarded €2.5m ERC grant to study RNA in living cells
FMI senior group leader Jeff Chao and his team have been awarded €2.5 million through the prestigious European Research Council Advanced Grant scheme to study how RNA controls gene expression in livin...
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Mike Dorrity @mwdorr.bsky.social · 19/06/2026
First pre-print from the lab, a collaborative effort led by Jess Bourn @bournsupremacy.bsky.social, a fantastic PhD in my group. We resolve a key problem in development + evolution: how do we quantify heterochrony and link temporal variation to phenotype? www.biorxiv.org/content/10.6...
biorxiv.org
Quantitative mapping of heterochrony to species-specific phenotypes
The genetic program of animal development is conserved, but its rate of execution varies across species. Heterochrony, shifts in the relative timing of developmental events, generates phenotypic varia...
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FMI science @fmiscience.bsky.social · 16/06/2026
We’re excited that the FMI is participating in the Doctoral Insights Symposium for the first time! Registration is now open — don’t miss this opportunity to explore top PhD programs in life sciences.
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Grosshans Lab @labgrosshans.bsky.social · 14/04/2026
Looking forward to seeing you all at the #aECM club today!👇
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meisterlab.bsky.social @meisterlab.bsky.social · 04/03/2026
Exciting news: Our RNA community in @uniregensburg.bsky.social is set to grow! We are opening a Junior Group Leader position in RNA biochemistry / ribonucleases / RNA stability. A great opportunity to start your own team within our collaborative RNA network. Details & application 👇
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Torben Heick Jensen @heick.bsky.social · 06/03/2026
Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here: mbg.au.dk/en/news-and-...
mbg.au.dk
Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
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Grosshans Lab @labgrosshans.bsky.social · 19/02/2026
Join us 👇. Together with our CompBio and Proteomics platforms, we'd love to work with you on examining protein dynamics!
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FMI science @fmiscience.bsky.social · 12/02/2026
🚀 We’re hiring! The Structural Biology Platform is seeking a Project Leader to advance cryo-electron tomography and expand capabilities at the FMI. Join a vibrant research community at the interface of structural biology, cell biology & disease mechanisms. Apply at: www.fmi.ch/education-ca...
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FMI science @fmiscience.bsky.social · 06/02/2026
👩‍🔬 On February 11, to mark the International Day of Women and Girls in Science, we’re hosting a panel discussion on how scientific progress and gender equality can advance together. The panel brings together voices from academia, industry, and EDI. Join us for this important conversation! #IDWGS
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FMI science @fmiscience.bsky.social · 05/02/2026
Now out in @currentbiology.bsky.social: neuroscientists in the lab of @felsenberg.bsky.social found that in fruit flies, re-tasting a sugar reward can weaken past memories, pointing to new ways to safely update harmful ones. www.fmi.ch/news-events/...
fmi.ch
How a sweet treat can change memories
Memories must be flexible so animals can adapt when the world changes. FMI neuroscientists found that in fruit flies, simply tasting a sugar reward again can weaken all previous associated memories. T...
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Johannes Felsenberg @felsenberg.bsky.social · 05/02/2026
Very thankful for this thoughtful dispatch by @shaisrael.bsky.social sky.social and Moshe Parnas about our work. Learning and memory: Forgetting to remember: Current Biology www.cell.com/current-biol...
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FMI science @fmiscience.bsky.social · 19/01/2026
Our annual brochure “Year in Review” is out now! It highlights the FMI’s key scientific publications, major events, and facts & figures from 2025, a year that marked our 55th anniversary. www.fmi.ch/news-events/...
fmi.ch
FMI Year in Review 2025
Our annual brochure highlighting the FMI’s key scientific publications, major events, and facts & figures from the past year is now available. Discover the highlights of 2025, a year that marked the F...
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Biozentrum, University of Basel @biozentrum.unibas.ch · 15/01/2026
Prof. Fiona Doetsch has been awarded the 2026 Louis-Jeantet Prize for Medicine! Her discoveries reveal how neural stem cells support lifelong brain plasticity and repair. 🧠 Read more: www.biozentrum.unibas.ch/news/detail/...
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Grosshans Lab @labgrosshans.bsky.social · 15/01/2026
RNA-binding proteins function through network effects, coordinately binding and weakly regulating many transcripts – or don’t they? Read our new preprint on how LIN28 controls developmental timing through only two targets, one mRNA, one miRNA. doi.org/10.64898/202...
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Grosshans Lab @labgrosshans.bsky.social · 08/12/2025
Please repost - position of Head of Student & Postdoc Affairs available at our Institute in the heart of Europe (Basel, Switzerland) 👇
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Oded Rechavi @odedrechavi.bsky.social · 25/11/2025
Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...
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Ursula von der Leyen @vonderleyen.ec.europa.eu · 10/11/2025
Switzerland is joining Horizon Europe! We are uniting two research powerhouses. For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more. Today is a good day for science, and for our EU-Switzerland partnership.
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Christa Buecker @chribue.bsky.social · 06/11/2025
And we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!
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FMI science @fmiscience.bsky.social · 04/11/2025
Now in @embojournal.org: Researchers in @labgrosshans.bsky.social & UCSC found that similar molecular machineries control daily circadian rhythms & developmental timing—showing that evolution can repurpose core timing systems to coordinate both daily cycles & growth. www.fmi.ch/news-events/...
fmi.ch
One clock, two functions: from daily rhythms to development
Scientists at the FMI and the University of California-Santa Cruz have found that similar molecular machineries control daily circadian rhythms and developmental timing. Their work in worms shows that...
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Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · 30/10/2025
Here is the schedule for the next TriRhena Gene Regulation Club at the FMI @fmiscience.bsky.social in Basel 🇨🇭 next week (5 Nov 2025; 14:00-18:45). Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI). www.ie-freiburg.mpg.de/grc
Programme of the upcoming TriRhena Gene Regulation Club in Basel on November 5, 2025

https://www.ie-freiburg.mpg.de/gene-regulation-club
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Grosshans Lab @labgrosshans.bsky.social · 29/10/2025
Nektarios Tavernarakis on why curiosity-driven research, not focusing on application, is fundamental to problem solving and requires government support in @emboreports.org doi.org/10.1038/s443...
doi.org
For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
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Grosshans Lab @labgrosshans.bsky.social · 29/10/2025
Flying worms! www.science.org/content/arti... (And I always wondered how worm cuticular alae (= wings) got their name 😉)
science.org
Bull’s-eye! Static electricity pulls worm through air to its insect victim
Electrostatic charges may help roundworms infect a wide variety of hosts
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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 24/10/2025
🔬 Next in the NCCR RNA & Disease Seminar Series: Prof. Olivia Rissland (Univ. of Colorado School of Medicine, USA)! 📅 27.10. 16:30 – University of Bern, DCBP 📅 28.10. 15:00 – ETH Zurich, Hönggerberg 👉 More info: nccr-rna-and-disease.ch/education/nc... @unibe.ch @ethz.ch @snf-fns.ch
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Wyoming Wormboy @wyomingwormboy.bsky.social · 22/10/2025
For what it’s worth, The Wyoming Worm lab has funding for 5 years along with exciting projects with solid foundations. We are is still looking for capable, dedicated, and fun-to-work-with lab members at all career stages. davidfay@uwyo.edu scholar.google.com/citations?us...
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Grosshans Lab @labgrosshans.bsky.social · 20/10/2025
And the next one: dx.doi.org/10.1038/s44318-025-00585-z . Super-fun collaboration with @partchlab.bsky.social & @gotworms.bsky.social to find similarities between developmental and circadian clocks – supported by @fmiscience.bsky.social Facilities and, financially, @snsf.ch and @erc.europa.eu . 1/n
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Piali Sengupta @senguptalab.bsky.social · 16/10/2025
Despite the mess, we are grateful to be funded, have exciting science happening, and have an opening for a postdoc! If you are interested in sensory biology and esp in cilia, thermosensation, or interoception, and would like to join an interactive & supportive group - please email. Please RT 🙏
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Grosshans Lab @labgrosshans.bsky.social · 15/10/2025
And here is a layperson video summary of parts of our recent paper👇
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FMI science @fmiscience.bsky.social · 15/10/2025
🎥 FMI scientists discovered that thousands of C. elegans genes switch on and off in rhythmic patterns controlled by chromatin, revealing how gene timing shapes development & offering clues to human biological clocks. @labgrosshans.bsky.social www.youtube.com/watch?v=Dibw...
youtube.com
DNA rhythms orchestrate gene activity across development
YouTube video by The Friedrich Miescher Institute for Biomedical Research
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Grosshans Lab @labgrosshans.bsky.social · 13/10/2025
Watch Lucas' amazing artistic/musical rendition of C. elegans larval development and our work on developmental timing and molting here youtu.be/-hGHYRvw87w and read on his inspiration and challenges below
youtu.be
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Teresa Rayon @trayon.bsky.social · 12/10/2025
Model organisms as platforms for training scientific minds www.nature.com/articles/s41...
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Grosshans Lab @labgrosshans.bsky.social · 10/10/2025
Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n
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Meera Sundaram @meera-sundaram.bsky.social · 23/09/2025
The 2025-2026 #aECM club schedule is now posted on our website, where you can also find the link to sign up for access. I’m looking forward to lots of great talks and discussions! sundaramlab.com/blog/aecm-cl...
sundaramlab.com
aECM Club Seminars
A virtual seminar series to highlight work on apical ECM across different systems Organizers: Meera Sundaram, UPennMax Heiman, Boston Children’s, Harvard U.Nathalie Pujol, U. Aix MarseilleJor…
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FMI science @fmiscience.bsky.social · 17/09/2025
Another FMI Annual Meeting is in the books! After a night of follies and plenty of dancing, today brought the announcement of our internal prize winners, more inspiring talks, and a vibrant poster session. Already looking forward to next year! 🙌
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SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 15/09/2025
 📅 Program of the NCCR RNA & Disease Seminar Series for the Autumn Semester 25/26:
For more information visit: nccr-rna-and-disease.ch/news/article...
 @unibe.ch @ethz.ch @snf-fns.ch
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FMI science @fmiscience.bsky.social · 12/09/2025
📣The Turco group is seeking a computational biologist to analyze large omics datasets. Work on cutting-edge 3D organoid models of the human placenta and be embedded in our Computational Biology Platform (part of @sib.swiss). Apply here: www.fmi.ch/education-ca...
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FMI science @fmiscience.bsky.social · 08/09/2025
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
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Grosshans Lab @labgrosshans.bsky.social · 08/09/2025
Thanks for highlighting - thread to follow. Mini-summary: beyond assigning oscillatory genes expression by scRNA-seq to individual cell types, we also show that chromatin opens rhythmically and that we can predict this (and gene expression) with a small set of TFs in a mathematical model.
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