Are you a DNMT3 enthusiast wondering how they achieve specificity at CpG islands during development? And why is DNMT3B specifically required for methylation on the inactive X?
We set out to dissect the mechanism, now published in Genes & Development
genesdev.cshlp.org/content/earl...
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genesdev.cshlp.org
Chromatin binding and N-terminal domains of DNMT3B1 confer specificity for developmentally regulated CpG island methylation
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