iiinova — where your digital self keeps evolving

Reposted by Stephen Methot

Schubeler Lab @schubelerlab.bsky.social · 07/05/2026

Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6... 1/9

biorxiv.org

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Reposted by Stephen Methot

Grosshans Lab @labgrosshans.bsky.social · 15/01/2026

RNA-binding proteins function through network effects, coordinately binding and weakly regulating many transcripts – or don’t they? Read our new preprint on how LIN28 controls developmental timing through only two targets, one mRNA, one miRNA. doi.org/10.64898/202...

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Reposted by Stephen Methot

Grosshans Lab @labgrosshans.bsky.social · 08/12/2025

Please repost - position of Head of Student & Postdoc Affairs available at our Institute in the heart of Europe (Basel, Switzerland) 👇

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Reposted by Stephen Methot

Olga Rosspopoff @orpsf.bsky.social · 15/11/2025

Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social #TEsky #TEworldwide authors.elsevier.com/c/1m6MC,LqAZ...

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Reposted by Stephen Methot

IGBMC @igbmc.bsky.social · 13/11/2025

The IGBMC is recruiting a new Computational Biology Group Leader through the ENACT AI Chair for Scientific Discoveries, covering cancer, developmental, and structural biology. Join one of Europe’s leading life science centers! cluster-ia-enact.ai/appels-a-pro... Deadline: Jan 7, 2026

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Reposted by Stephen Methot

Annika Hausmann @hausmannannika.bsky.social · 11/11/2025

Jo in our team - we are looking for a PhD student, postdoc or lab manager! More information and links to job portal for application submission: lnkd.in/dcU2Vg7W lnkd.in/dgVKTARV Please share widely 🙏🏼 @yefis-immunology.bsky.social @syis-ecr.bsky.social

lnkd.in

Postdoc or PhD student position in molecular dissection of cellular crosstalk in the intestinal mucosa

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Reposted by Stephen Methot

FMI science @fmiscience.bsky.social · 29/10/2025

Three FMI researchers—Nanci Winke, @neuramos.bsky.social & @lukas-anneser.bsky.social—have received @snsf.ch Ambizione Grants! Their projects explore how emotions shape behavior, how the brain responds to anxiety treatments, and how brain states affect learning & memory 🧠 www.fmi.ch/news-events/...

fmi.ch

Three FMI researchers awarded coveted SNSF Ambizione Grants

Three FMI researchers — Nanci Winke, Arnau Ramos Prats, and Lukas Anneser — have been awarded a prestigious Ambizione Grant from the Swiss National Science Foundation (SNSF). Their work spans from unc...

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Reposted by Stephen Methot

Grosshans Lab @labgrosshans.bsky.social · 20/10/2025

And the next one: dx.doi.org/10.1038/s44318-025-00585-z . Super-fun collaboration with @partchlab.bsky.social & @gotworms.bsky.social to find similarities between developmental and circadian clocks – supported by @fmiscience.bsky.social Facilities and, financially, @snsf.ch and @erc.europa.eu . 1/n

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Reposted by Stephen Methot

The EMBO Journal @embojournal.org · 21/10/2025

Shared mechanisms across distinct biological clocks: Jordan Ward @gotworms.bsky.social , Helge Grosshans @labgrosshans.bsky.social & collaborators find the nematode homologs of mammalian circadian clock proteins PERIOD & CK1 to control developmental timing in worms www.embopress.org/doi/full/10....

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Reposted by Stephen Methot

FMI science @fmiscience.bsky.social · 15/10/2025

🎥 FMI scientists discovered that thousands of C. elegans genes switch on and off in rhythmic patterns controlled by chromatin, revealing how gene timing shapes development & offering clues to human biological clocks. @labgrosshans.bsky.social www.youtube.com/watch?v=Dibw...

youtube.com

DNA rhythms orchestrate gene activity across development

YouTube video by The Friedrich Miescher Institute for Biomedical Research

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Reposted by Stephen Methot

Teresa Rayon @trayon.bsky.social · 12/10/2025

Model organisms as platforms for training scientific minds www.nature.com/articles/s41...

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Reposted by Stephen Methot

Grosshans Lab @labgrosshans.bsky.social · 10/10/2025

Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n

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Reposted by Stephen Methot

SIRD - Swiss Initiative for RNA & Disease @swissinitiativerna.bsky.social · 01/10/2025

Preprint by the Grosshans lab w/ co-1st authors Dimos Gaidatzis, Maike Graf-Landua & Stephen P. Methot "A scheduler for rhythmic gene expression" @biorxivpreprint.bsky.social doi.org/10.1101/2025... @labgrosshans.bsky.social @smethot.bsky.social @fmiscience.bsky.social

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Reposted by Stephen Methot

Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 03/07/2025

📖 Happy to share our recent preprint! www.biorxiv.org/content/10.1... We discovered how SINEs are kept silent: the ChAHP protein complex acts as a molecular brake on POL III transcription retrotransposons. A 🧵:

biorxiv.org

ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment

Short interspersed nuclear elements (SINEs) are abundant non-autonomous transposable elements derived from RNA polymerase III (POL III)-transcribed short non-coding RNAs. SINEs retain sequence feature...

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Reposted by Stephen Methot

FMI science @fmiscience.bsky.social · 26/09/2025

We’re excited to host the next TriRhena Gene Regulation Club on November 5! Attendance is free, but registration (by October 20) is mandatory 👇🏽

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Reposted by Stephen Methot

Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 24/09/2025

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication. www.biorxiv.org/content/10.1... A🧵👇

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Reposted by Stephen Methot

Julia Batki @juliabatki.bsky.social · 14/09/2025

I am excited to announce that we are looking for a Lab Manager @fmiscience.bsky.social in Basel. If you want to be part of a growing team investigating development and tissue formation, and are enthusiastic about helping set up a new lab, please check out the role: www.fmi.ch/education-ca...

fmi.ch

Friedrich Miescher Institute, open position

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Reposted by Stephen Methot

Max Heiman @heiman.bsky.social · 07/09/2025

New preprint! How are developmental cycles coordinated across cell types? It turns out that, like Geppetto's cuckoo clocks in the GIF below, individual cell types are each performing their own little crazy routine, but all in sync with each other.

media.tenor.com

a bunch of clocks are hanging on a wall including one that says ' 3:00 ' on it

ALT: a bunch of clocks are hanging on a wall including one that says ' 3:00 ' on it

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Reposted by Stephen Methot

FMI science @fmiscience.bsky.social · 08/09/2025

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

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Reposted by Stephen Methot

Kazuhiro Maeshima @kazu-maeshima.bsky.social · 28/08/2025

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. www.biorxiv.org/cgi/content/...

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Reposted by Stephen Methot

Julia Batki @juliabatki.bsky.social · 25/08/2025

I am excited to share that I will join the Friedrich Miescher Institute @fmiscience.bsky.social in Basel as a group leader, starting my lab in March 2026 🎉 We will explore cell fate regulation during organogenesis, with a focus on how cell elimination underlies the emergence of functional tissues.

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Reposted by Stephen Methot

Schubeler Lab @schubelerlab.bsky.social · 12/08/2025

Excited to share our latest preprint. www.biorxiv.org/content/10.1.... Lead by Lukas, we investigated multiple ways of assessing a TF's sensitivity to chromatin based on genome-wide binding profiles. The developed methods allowed us to quantify chromatin sensitivity across tested TFs.

biorxiv.org

A novel deep learning-based framework reveals a continuum of chromatin sensitivities across transcription factors

The genome-wide binding of many transcription factors (TFs) depends not only on the presence of their recognition motifs, but also on the surrounding chromatin context. This raises the question of how...

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Reposted by Stephen Methot

Schubeler Lab @schubelerlab.bsky.social · 07/08/2025

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....

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Reposted by Stephen Methot

Erich M. Schwarz @erichmschwarz.bsky.social · 01/08/2025

After 10 years of work, a complete telomere-to-telomere gap-free genome for C. elegans finally exists: it has 106 Mb rather than the textbook 100.3 Mb, and up to 366 additional genes. genome.cshlp.org/content/35/8...

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Reposted by Stephen Methot

Annika Hausmann @hausmannannika.bsky.social · 18/07/2025

📢Master thesis project opportunity ‼️We are looking for a motivated Master student to join the lab working on semi-automated analysis pipelines for organoid microscopy images. Please spread the word and check out our website for more information: www.annikahausmannlab.com

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Reposted by Stephen Methot

Charlène Boumendil (She/Her) @charleneboumendil.bsky.social · 21/07/2025

Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!

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Stephen Methot @smethot.bsky.social · 14/03/2025

Job opening in my research group!! Please share. I'm looking for a lab technician to join my small team investigating how chromatin structure regulates gene expression in C. elegans. www.fmi.ch/education-ca...

fmi.ch

Friedrich Miescher Institute, open position

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