The hyphae-to-yeast morphological transition promotes dissemination of the pathogen Candida albicans, but the mechanisms underlying this process are poorly defined. By identifying a bacterial metaboli...

Cellularization as a mechanism to build cells

Scientific Reports - The circadian clock gene period regulates the composition and daily bacterial load of the gut microbiome in Drosophila melanogaster

An alkyne-tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the...

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Aneuploidy and oxidative stress have each been implicated in impaired embryonic development, yet their relationship remains unclear. Here we discover a self-reinforcing ROS-aneuploidy feedback loop wi...

Molecular biology; Omics

Cytoplasmic divisions are thought to rely on nuclear divisions and mitotic signals. We demonstrate in Drosophila embryos that cytoplasm can divide rep…

Latest advances in biological timing studies substantiate an emerging concept of autonomous clocks that are normally entrained by the cell cycle and/or the circadian clock to run in synchrony, but hav...

The Trumanlab at UNC Charlotte incorporates protein biochemistry, molecular biology, proteomics, systems biology, bacterial and yeast genetics as well as cell culture technologies to identify novel an...

Worcester et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study lipids.

A DNA nanoruler platform enables precise measurement of the labeling radii of TurboID and APEX2, uncovering their contact-dependent mechanisms. These findings redefine the enzymology of proximity labe...

The positional relationships among all of the visible organelles in a densely packed region of cytoplasm from an insulin secreting, cultured mamm...

Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...

The proliferation of eukaryotic cells is regulated by a complex network of regulatory systems that promotes efficient cell cycle progression and ensures proper responses to the environment. Despite th...