iiinova — where your digital self keeps evolving

Reposted by Andy Truman PhD

Anna Leder @annaleder.bsky.social · 21/09/2026

A huge thank you to my co-first authors Raju and @masgu.bsky.social, our collaborators Nadinath Nillegoda, @trumanlab.bsky.social, @paolodelosrios.bsky.social, @chercheurjuteux.com, @hillerlab.bsky.social and everyone else involved!

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Reposted by Andy Truman PhD

Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 17/09/2026

A conserved tyrosine motif encodes a structural vulnerability controlling stability and activity across J-domain proteins This interesting story, which involved several labs and some ideas of my own, has finally been released. www.nature.com/articles/s42...

nature.com

A conserved tyrosine motif encodes a structural vulnerability controlling stability and activity across J-domain proteins - Communications Biology

NMR spectroscopy and functional assays define a conserved tyrosine motif outside the canonical J-domain core of J-domain proteins. The motif stabilizes the fold, and its phosphomimetic perturbation dr...

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Andy Truman PhD @trumanlab.bsky.social · 27/04/2026

Honored and humbled to have received the UNC Charlotte Klein College of Science Excellence in Research Award (Advanced Scholar) for our work on Proteostasis and the Hsp70 chaperone code 🔥

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Reposted by Andy Truman PhD

Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 15/04/2026

Voilà enfin le papier dont je vous parlais depuis un petit temps. Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system febs.onlinelibrary.wiley.com/doi/10.1111/...

febs.onlinelibrary.wiley.com

FEBS Press

Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co-chaperones such as JDPs and NEF...

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Andy Truman PhD @trumanlab.bsky.social · 18/09/2025

Colleague Shan Yan doing a great job highlighting our Genome research at the NC Biotech Summit at the newly opened Pearl campus in Charlotte!

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Andy Truman PhD @trumanlab.bsky.social · 13/09/2025

Had a wonderful time visiting Marquette University Biological Sciences to share our recent work on the Hsp70 Chaperone Code! Thanks to Emily Sontag for inviting me! Such a beautiful campus and loved talking with the students and faculty about the exciting research going on 🔥🔥🔥#hsp70

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Reposted by Andy Truman PhD

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · 10/09/2025

This study, led by Megan Mitchem & Ashley Choi at the Truman Lab (@trumanlab.bsky.social), provides a resource for dissecting the functional landscape of Cdc37 post-translational regulation & highlights new regulatory sites w/potential relevance to chaperone-kinase network dysregulation in disease.

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Andy Truman PhD @trumanlab.bsky.social · 20/08/2025

Friday was the 10th anniversary of setting up my lab! My amazing team hosted a party-the showstopper was the video they made that contained messages from all my previous students, mentors and collaborators!Finished the day by failing Beat the bomb in Charlotte!

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Andy Truman PhD @trumanlab.bsky.social · 06/08/2025

@ronbeavis.bsky.social Hi Ron, I teach a graduate course on cell signaling and each year do a couple of classes on PTMs. I love showing the students how to use the gpmdb for their studies but can’t access it anymore from the US. Do you offer paid access/educational discount for those in the US?

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Andy Truman PhD @trumanlab.bsky.social · 01/07/2025

Excited to begin my new role as Associate Chair for Research in the Department of Biological Sciences at UNC Charlotte 🔥🔥

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Andy Truman PhD @trumanlab.bsky.social · 13/06/2025

Great time celebrating the achievements of the lab at Fahrenheit restaurant-graduations, proposal defenses, papers and grants! So grateful for the hard work and energy my team bring!

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Reposted by Andy Truman PhD

Andy Truman PhD @trumanlab.bsky.social · 08/09/2023

A really important skill for trainees to learn is to be a “closer” of a project-that is to take it over the finish line for publication. This means doing the experiments, getting the figures/text ready for submission and being prepared to do review corrections 😀

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Andy Truman PhD @trumanlab.bsky.social · 05/06/2025

Classic NIH shenanigans-R03 scores: A0: ND A1: 26 (need 25 to be funded) Revised A0: 40 😭

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Reposted by Andy Truman PhD

Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 03/06/2025

On adaptation to a mesophilic environment and the chaperone network in Archaea Hopla il est là et je ferais une petite explication de ce que j'ai cherché à comprendre dedans. Mais ça parle de chaperonnes et d'archées et de relations entre évolution et HSP70. www.biorxiv.org/content/10.1...

biorxiv.org

On adaptation to a mesophilic environment and the chaperone network in Archaea

A prevailing hypothesis for the emergence of life on Earth holds that it might have originated in hydrothermal vents, where the environmental conditions, although physically and chemically extreme (ac...

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Andy Truman PhD @trumanlab.bsky.social · 12/05/2025

Grateful to have been awarded the first UNC Charlotte Klein College of Science award for Research and Scholarship (KNOBEL) 🔥🔥🔥

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Andy Truman PhD @trumanlab.bsky.social · 24/04/2025

Another Hsp70-Hsp90 complex spotted in the wild 🔥🔥🔥

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Andy Truman PhD @trumanlab.bsky.social · 17/04/2025

Proud of undergraduate students Shreya Patel and Erica Flores on doing a great job presenting their work at the University of North Carolina at Charlotte Undergraduate Research Symposium! Incredible findings on the Hsp70 and BiP PTM code!

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Reposted by Andy Truman PhD

Saccharomyces Genome Database @yeastgenome.bsky.social · 20/03/2025

The Pacific Northwest Yeast Club is holding their annual meeting on June 20th, 2025 in beautiful Vancouver, Canada! There are only 100 spots and registration is open now: www.pnwyc.net

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Reposted by Andy Truman PhD

Yeast Journal @yeast-journal.bsky.social · 10/02/2025

Hi everybody! The Yeast journal is finally on Bluesky! Follow us to keep updated on the latest research articles, reviews and special issues on #Yeast biology and more! 🙂

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Andy Truman PhD @trumanlab.bsky.social · 27/03/2025

The celebration of UNC Charlotte reaching R1 status was such a positive and inspiring event! Go Niners 🔥🔥🔥

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Andy Truman PhD @trumanlab.bsky.social · 06/03/2025

Our inaugural Rising Stars in Proteostasis seminar was a roaring success! Thanks to Dr. Ian Guldner for visiting from Stanford University and giving an amazing talk on the decline of proteostasis in aging 🔥🔥🔥 #proteostasis #charlotte

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Andy Truman PhD @trumanlab.bsky.social · 05/03/2025

Access to the GPM database removed for US researchers 😬

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Andy Truman PhD @trumanlab.bsky.social · 02/03/2025

I can no longer access pubmed or eracommons WTH is going on????

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Reposted by Andy Truman PhD

Mark Peifer (He, him) @peiferlabunc.bsky.social · 01/03/2025

In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n www.nature.com/articles/s41...

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Reposted by Andy Truman PhD

Elaine Luo @oceanmicrobes.bsky.social · 20/02/2025

Hi everyone! New here 😄 excited to connect and learn about/share cool research in aquatic microbial ecology, or just science in general! Here's our lab photo to kick-start another year! #newPI

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Andy Truman PhD @trumanlab.bsky.social · 18/01/2025

Incredible as always-Rick Morimoto gives the final talk of the day at the Midwest Stress Response and Molecular Chaperone Meeting 🔥

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Andy Truman PhD @trumanlab.bsky.social · 18/01/2025

So excited to be back in Chicago for the Midwest Stress Meeting!

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Andy Truman PhD @trumanlab.bsky.social · 16/12/2024

We’ve had a great response so far! Please forward to any researchers that may be interested! 😀

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Reposted by Andy Truman PhD

D. Allan Drummond @dadrummond.art · 12/12/2024

Merry #Crustmas. Now get off my lawn

My drawing of a very grumpy hermit crab, drawn from life in crosshatched black pen. He has looong antennae and wonderful angry eyes. 🐡

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Andy Truman PhD @trumanlab.bsky.social · 12/12/2024

The Proteostasis Group at UNCC are excited to announce the Rising Stars in Proteostasis seminar series! This is open to postdoctoral researchers in the US. We have funds to pay for travel costs. If you are interested, please complete the google form here:https://forms.gle/b6ZTPfw5WMaqb7H18

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Andy Truman PhD @trumanlab.bsky.social · 09/12/2024

Excited to share our latest study PLOSGenetics "Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity". Thanks to Siddhi Omkar Megan Mitchem and Courtney Shrader 🔥https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011338

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Andy Truman PhD @trumanlab.bsky.social · 06/12/2024

Humbled to have been awarded the Outstanding Faculty Research Award by the department of biological sciences at UNC Charlotte 😀

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Reposted by Andy Truman PhD

Michael Baym @baym.lol · 02/12/2024

Finally my startup to do point-of-meal sequence verification of fish cuts has a name. Fillet MinION

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Reposted by Andy Truman PhD

Mark Peifer (He, him) @peiferlabunc.bsky.social · 01/12/2024

Phenomenally useful and interesting comparison of the timescale of different events inside cells! 🧪

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Reposted by Andy Truman PhD

D. Allan Drummond @dadrummond.art · 28/11/2024

Thankful for these little ones who make our bread, beer, and wine #thanksgiving #sciart

A metal sculpture of a budding yeast cell (Saccharomyces cerevisiae) in late cell division, with a large mother cell budding off a smaller daughter cell, in my hand against a white background. The cell wall is cut away to show many complex, fluid internal structures, including the nucleus and gemstone chromosomes separating after replication, mitochondria with little internal ribbed membranes, the endoplasmic reticulum, and many more. Cell wall is steel, organelles are bronze, mitotic spindle is silver, and the gemstones are apatite, which gets its blue-green color from phosphorus--the element that forms the backbone of DNA.

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Reposted by Andy Truman PhD

Jon Lim, FRCP PhD @drjonlim.bsky.social · 23/11/2024

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

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Andy Truman PhD @trumanlab.bsky.social · 19/11/2024

Had a great time at the UNC Charlotte Research Reception! Thanks go to the Division of Research for organizing such a great event!

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Reposted by Andy Truman PhD

Paolo De Los Rios @paolodelosrios.bsky.social · 11/11/2024

First post here. I am interested in chaperone proteins: how do cells counteract/revert protein misfolding and aggregation? What are the physics principles that allow these machines to work? Are native proteins in the cell thermodynamically stable? 1/4

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