Naydenova, Mund, Yip, et al. investigate the innate immune sensor ZNFX1, an RNA helicase and E3 ubiquitin ligase. Cryo-EM structures reveal that ZNFX1 is an auto-inhibited RNA helicase that forms large helical assemblies. Both ZNFX1 assemblies and ubiquitin ligase activity regulate ZNFX1 stability. Disease-associated mutations disrupt catalytic activities of ZNFX1.

Nature Reviews Molecular Cell Biology, Published online: 05 October 2026; doi:10.1038/s41580-026-01023-6Chaperone-mediated autophagy (CMA) is a selective lysosomal degradation pathway. Recent insights into its regulation, substrate repertoire and therapeutic modulation have revealed organ-specific functions and highlighted CMA as a therapeutic target in ageing and disease.

All cells experience mechanical forces, yet how they increase energy production to meet the demands of force response remains incompletely understood. This

The endoplasmic reticulum (ER)-Golgi interface is a dynamic trafficking hub maintained in part by TANGO1, a scaffolding protein that coordinates proteins and membranes at ER exit sites (ERES). TANGO1 ...

Lennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

Re-engineering a highly conserved metabolic pathway in yeast prevents age-related functional decline and proves that ageing is not inevitably linked to loss of fitness.

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Akbari et al. investigated the mechanisms of linker histone H1.0 loading onto nucleosomes. H1.0 directly binds nucleosomes and DNA, while DNA-bound H1.0 is mobile but does not load onto nucleosomes. Linker histone chaperones facilitate H1.0 loading through enhancing nucleosome binding, increasing H1.0 mobility, and enabling H1.0 loading through DNA sliding.

Polo-like kinase 1 (Plk1) regulates multiple steps of the cell and centrosome cycle, including mitotic entry, DNA-damage recovery, centrosome maturation and centriole disengagement. Plk1 activity depends on several independent cofactors, such as the cytoplasmic Bora, and the centrosomal proteins Cep192 and Cenexin. However, whether these Plk1 coactivators differentially regulate the Plk1-dependent processes is unknown. Here, we show that each Plk1 coactivator controls different cell and centrosome cycle transitions in human cells. We find that Plk1 already acts in S-phase, where under the control of Cep192 and Aurora A it promotes replication origin firing. Bora is the main Plk1 activator driving mitotic entry, DNA-damage recovery and centrosome maturation in G2, while centriole disengagement is mainly regulated by Cep192 and Cenexin. Our results thus uncover a complex Plk1 activation regulatory network, in which distinct upstream activators dictate its activity in a context-dependent

The Arp2/3 complex in mammals, consists of 8 iso-complexes with different properties as there are two isoforms of the Arp3, ArpC1 and ArpC5 subunits. All iso-complexes still generate actin branches wh...

Xu et al. identify a membrane responsive segment in the HLA-A cytoplasmic tail that promotes receptor internalization and limits surface retention. Disrupting this region, genetically or with a tail-derived peptide, reduces internalization and preserves surface HLA-I, revealing a receptor intrinsic mechanism that regulates antigen presenting complex availability.

This study explores the use of graphene reservoirs formed over perforated supporting films as a method to precisely control ice thickness during cryo-EM sample preparation.

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This study explores the use of graphene reservoirs formed over perforated supporting films as a method to precisely control ice thickness during cryo-EM sample preparation.

Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to stress and whose deregulation underlies tumorigenesis in follicular lymphoma.

Nature Microbiology, Published online: 02 October 2026; doi:10.1038/s41564-026-02501-5A GTPase complex conserved across alveolates gates exocytosis in the parasite Toxoplasma and the ciliate Tetrahymena. In Toxoplasma, an added apical vesicle tightens control over rhoptry secretion, a process critical to host cell invasion.

The Ras subfamily is the most extensively studied branch of the Ras superfamily, with 20% of all human tumors having activating mutations in one of the RAS genes. Recent studies have shown that the…

Protein misfolding in the endoplasmic reticulum (ER) of podocytes/glomerular epithelial cells (GECs) induces ER stress and contributes to the pathogenesis of glomerular disease. Activation of IRE1α an...

Lipid droplets (LDs) are assembled at discrete endoplasmic reticulum (ER) subdomains whose local phospholipid composition, rather than their protein content alone, determines whether a LD nucleates an...

Acanthamoeba castellanii, a pathogenic amoeba, belongs to an evolutionary branch distinctly removed from humans and fungi. Cryo-EM of the organism’s ATP synthase enzyme using raw mitochondrial lysates...

3-Phosphoinositides are essential cellular lipids regulating health and disease. Among them, phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] remains the least understood. Using a newly developed rat...