The Arp2/3 complex in mammals, consists of 8 iso-complexes with different properties as there are two isoforms of the Arp3, ArpC1 and ArpC5 subunits. All iso-complexes still generate actin branches wh...

Xu et al. identify a membrane responsive segment in the HLA-A cytoplasmic tail that promotes receptor internalization and limits surface retention. Disrupting this region, genetically or with a tail-derived peptide, reduces internalization and preserves surface HLA-I, revealing a receptor intrinsic mechanism that regulates antigen presenting complex availability.

This study explores the use of graphene reservoirs formed over perforated supporting films as a method to precisely control ice thickness during cryo-EM sample preparation.

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This study explores the use of graphene reservoirs formed over perforated supporting films as a method to precisely control ice thickness during cryo-EM sample preparation.

Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to stress and whose deregulation underlies tumorigenesis in follicular lymphoma.

Nature Microbiology, Published online: 02 October 2026; doi:10.1038/s41564-026-02501-5A GTPase complex conserved across alveolates gates exocytosis in the parasite Toxoplasma and the ciliate Tetrahymena. In Toxoplasma, an added apical vesicle tightens control over rhoptry secretion, a process critical to host cell invasion.

The Ras subfamily is the most extensively studied branch of the Ras superfamily, with 20% of all human tumors having activating mutations in one of the RAS genes. Recent studies have shown that the…

Protein misfolding in the endoplasmic reticulum (ER) of podocytes/glomerular epithelial cells (GECs) induces ER stress and contributes to the pathogenesis of glomerular disease. Activation of IRE1α an...

Lipid droplets (LDs) are assembled at discrete endoplasmic reticulum (ER) subdomains whose local phospholipid composition, rather than their protein content alone, determines whether a LD nucleates an...

Acanthamoeba castellanii, a pathogenic amoeba, belongs to an evolutionary branch distinctly removed from humans and fungi. Cryo-EM of the organism’s ATP synthase enzyme using raw mitochondrial lysates...

3-Phosphoinositides are essential cellular lipids regulating health and disease. Among them, phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] remains the least understood. Using a newly developed rat...

Nature Structural & Molecular Biology, Published online: 30 September 2026; doi:10.1038/s41594-026-01877-6Koenig et al. present a phosphoproteome atlas of 33 human cell lines covering >200,000 phosphosites, advancing cellular kinase activity scoring and drug sensitivity prediction, providing a resource for cell signaling insights and precision oncology.

Nature Structural & Molecular Biology, Published online: 30 September 2026; doi:10.1038/s41594-026-01898-1Advances in phosphoproteomics enable systems-wide mapping of phosphorylation, but translating these data into functional signaling networks remains challenging. A deep human cell-line phosphoproteome atlas infers kinase activity, enabling systematic network mapping and identification of actionable kinase vulnerabilities for precision therapies.

Cryogenic electron microscopy (cryo-EM) has enabled rapid progress in structural biology throughout the last decade. However, cryo-EM sample preparation still represents a major bottleneck in high-res...

Cryogenic electron microscopy (cryo-EM) has enabled rapid progress in structural biology throughout the last decade. However, cryo-EM sample preparation still represents a major bottleneck in high-res...

Protein synthesis declines with age across many tissues, but whether this decline actively contributes to physiological aging remains unclear. Oocytes may be particularly vulnerable because they rely ...

3-Phosphoinositides are essential cellular lipids regulating health and disease. Among them, phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] remains the least understood. Using a newly developed rat...

A study employs ChIP-CryoEM to determine structures of CENP-A nucleosomes isolated from human cells. Homotypic CENPA and heterotypic CENP-A/H3 nucleosomes are octameric and retain hallmark CENP-A stru...

Autophagic degradation of parts of the nucleus (nucleophagy) and endoplasmic reticulum (ER-phagy) utilizes the selective autophagy receptors, Atg39...

Fluorescent proteins are widely used as quantitative reporters of protein abundance in living cells. Here we show that this relationship can break down under translation inhibition: the cellular ribos...

Heat shock protein 70 (Hsp70) is a molecular chaperone that plays a key role in cellular processes by assisting protein folding and preventing aggregation. During client-protein folding, Hsp70…