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Michelle Fry

@myfry.bsky.social

408 followers 288 following 24 posts

🙋‍♀️🐚💴🍟,👩‍🔬

Michelle Fry @myfry.bsky.social · 02/10/2026

1/ 🧵 Two classic mitochondrial pathways the TCA cycle and OXPHOS are taught as linked but distinct pathways. I’m happy to share our new work out in @cp-cell.bsky.social showing that in Acanthamoeba they're physically linked—with a TCA enzyme incorporated in ATP synthase. www.cell.com/cell/fulltex...

cell.com

Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS

Acanthamoeba castellanii, a pathogenic amoeba, belongs to an evolutionary branch distinctly removed from humans and fungi. Cryo-EM of the organism’s ATP synthase enzyme using raw mitochondrial lysates...

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Reposted by Michelle Fry

Jane Coffin Childs Fund for Medical Research @jcchildsfund.bsky.social · 19/05/2026

Jane Coffin Childs Fellow Dr. Michelle Fry studies perhaps the most iconic organelle of the cell, the mitochondria. Almost everyone knows that mitochondria are the powerhouse of the cell, but few know they are essential for other functions like respiration and ... @myfry.bsky.social 1/

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Michelle Fry @myfry.bsky.social · 03/10/2024

Excited to share our collaborative work characterizing a pathogenic mutation in Opa1 found in ADOA patients that began when Tom Schwarz @BostonChildrens presented a seminar @MGHMolBio biorxiv.org/content/10.1... @lukechao.bsky.social

biorxiv.org

Loss of SARM1 protects against retinal ganglion cell degeneration in Autosomal Dominant Optic Atrophy

Autosomal Dominant Optic Atrophy (ADOA), the most prevalent inherited optic neuropathy, leads to retinal ganglion cell (RGC) degeneration and vision loss. ADOA is primarily caused by mutations in the ...

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