Modern microscopy generates data volumes that far exceed human analytical capacity. Over the past decade, artificial intelligence (AI) has transformed microscopy image analysis into an engine for quan...

Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...

The protein landscapes that underlie multicellular self-organization remain challenging to characterize across intact embryos at high spatial resolution. Here, the authors present 3D-4i, a high-throug...

The mammalian liver possesses a regenerative capacity that is unmatched by any other organ. Following injury, liver epithelial cells can proliferate or even change their identity, enabling the organ t...

Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...

Historian William Dalrymple joins Zack Polanski on Bold Politics to explain how one corporation conquered India, how Britain created the conditions for the Nakba - and why none of it is on the school ...

YouTube video by Bold Politics with Zack Polanski

The Tapenade pipeline enables single-cell, whole-mount 3D quantification in dense multilayer organoids, linking spatial gene co-expression and nuclear deformation to emerging tissue-scale organization...

An accessible light-sheet microscope delivers subcellular-resolution, multicolor volumetric, and live-cell imaging, lowering barriers to state-of-the-art performance.

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The control of animal homeostasis and repair has been studied for decades, mostly from a molecular and biochemical perspective. Recent research shows that biophysical factors, such as mechanical forc…

Neuroscience experts convened in Asilomar to talk through guidelines around ethical research on human neural organoids.

Cell-extrinsic cues are key for neocortical cell identity and diversity.

The mechanics of embryonic tissue spreading over spherical eggs is not fully understood. Here, the authors show that during gastrulation in the red flour beetle, extraembryonic tissue epiboly is facil...

A small tissue fold present in fruit fly embryos buffers mechanical stresses and may have evolved in response to mechanical forces.