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A personalized mRNA cancer vaccine succeeded in a late-stage melanoma study, results that could herald a new, powerful approach in oncology.

Take a look at a great career opportunity where you can make a real difference at UCLA Health

Genetic background shapes how human cells proliferate and respond to environmental stress. Using pooled, multi-donor human neural progenitor cell villages and the compositional model Townlet, we quant...

The incumbent performs limited grants management analysis assignments that are developmental and recurring in nature including functions such as the following: assisting a higher-level specialist in c...

Dr. Aparna Bhaduri, assistant professor of medicine and biological chemistry at the David Geffen School of Medicine at UCLA, has been named a recipient of the 2026 Pershing Square Sohn Cancer Prize, a...

Genome-wide association studies have identified thousands of intergenic variants associated with disease, most of which are presumed to act by affecti…

Take a look at a great career opportunity where you can make a real difference at UCLA Health

Deep mutational scanning (DMS) coupled with fluorescence-activated cell sorting (FACS) provides a high-throughput method to link genetic variants with quantitative molecular phenotypes. Analysis of th...

Cells continually encounter environmental stressors that challenge homeostasis. How three-dimensional (3D) chromatin structure contributes to these stress responses, particularly under hyperosmotic co...

A Trump administration change to how NIH awards grants has sharply reduced early-stage investigators’ odds of securing funding.

How do cis-regulatory differences, across mouse subspecies over timescales, shape cell-type specification and maturation during corticogenesis? In this issue of Developmental Cell, Medina-Cano et al. ...

The Emerging Genomic Scientist Fellows Program showcases innovative research from junior scientists

Psilocybin reshapes brain networks through activity-dependent plasticity, including a weakening of recurrent cortical loops that could underlie its therapeutic effects.

The capacity of neurons to maintain stable activity levels through homeostatic plasticity is essential for proper brain function. Primary cilia, which are non-motile, antenna-like organelles projectin...

Using SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in Scn2a haploin...

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Toxic ‘forever chemicals’ were found at a level 10 times higher than people who did not work in contaminated zone

Air pollution from oil and gas production and use in the U.S. has an enormous health toll. A new study tallies the cost.

How embryo selection exploits our flawed intuitions about risk

A new Danish study finds no association between aluminum in childhood vaccines and 50 different health conditions, including autism, asthma, and autoimmune diseases. The findings reaffirm the safety o...

The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem cells, revealing vulnerabi...

Detection of cancer before a clinical diagnosis could give patients and caregivers more time for intervention and may lead to better outcomes because tumors are more likely to be curable

A virtual seminar series focusing on stem cell models and functional variation across human iPSC lines. Monthly virtual seminar series, held on one Tuesday o...

Background Neurodevelopmental disorders (NDDs) are a challenging group of disorders to treat, but promising therapeutic interventions in the form of antisense oligonucleotides (AONs) have emerged in r...