During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

Rigidity transitions govern tissue organization in ways reminiscent of inert materials. Yet, living tissues are composed of active units with autonomous timing mechanisms, raising the question whether...

How rigid a tissue is coordinates a crucial period of cell patterning, ensuring that embryos develop the right shape and organise their cell layers correctly at the same time.

Opportunities for postdoctoral clinicians to consolidate their research experience.

Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.

When stimulated by nucleation-promoting factors such as WAVE, the Arp2/3 complex generates branched actin networks. In contrast, when activated by SPIN90, the Arp2/3 complex generates linear actin fil...

Inge et al. show that human endoderm originates from two converging developmental routes with distinct dynamics and efficiencies yet similar developmental potential. Combinatorial activin and BMP4 sig...

Spatial maps reveal dynamic epithelial-mesenchymal niches shaping pancreatic development and function.

Mice lacking a gene responsible for cell structure lose intestinal balance and experience systemic inflammation, mirroring a lethal condition seen in humans.

Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion...

Targeting AMPK as a metabolic vulnerability of metastatic cancer cells

The historical order in which mutations appear during evolution determine the evolutionary trajectory of gene regulatory networks and influence how developmental patterns change and diversify over tim...

Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…

The American Society for Cell Biology (ASCB) is proud to announce the election of 14 outstanding scientists as 2025 ASCB Fellows—a prestigious honor recognizing their exceptional contributions to cell...

The placenta supports the foetus by mediating nutrient and gas exchange, hormone production, and immune protection. Yet, human placental biology remains poorly understood due to limited in vitro model...