An analogy with wetting has proven apt for describing how groups of cells spread on a substrate. But cells are active: they polarize, generate forces and adhere to their surroundings. Experiments now ...

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

Engineering Biology for Biomedicine A UKRI:BBSRC Centre for doctoral training Why EB4BM “ Our graduates bridge fundamental biological design principles with biomedical bottlenecks, delivering engineer...

Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.

van der Net et al. show that mechanical interactions with the stromal component collagen I trigger reprogramming of colorectal cancer cells into a fetal-like state, through mechanosensitive integrins ...

Women over 35 experience a marked reduction in fertility. The origin of these fertility defects appears to reside in the implantation capacity of the embryo itself, but the mechanistic basis of this i...