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Maria Alcolea

@mariapalcolea.bsky.social
456 followers 219 following 53 posts

Associate Professor. Cambridge Stem Cell Institute, University of Cambridge, UK. Interested in epithelial cell fate plasticity and early tumorigenesis.

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Reposted by Maria Alcolea
Bardin Lab @bardinlab.bsky.social · 30/04/2026
Invited faculty: Maria Alcolea @mariapalcolea.bsky.social , Isabel Farinas , Robin Franklin, Elisa Gomez Perdiguero , Vincent Guen Charlène Guillot , Fabrice Lavial , Cédric Maurange @cedricmaurange.bsky.social, Stéphane Nédelec, Phong Nguyen, Mekayla Storer @storerlab.bsky.social, Ludovic Vallier
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Reposted by Maria Alcolea
Bardin Lab @bardinlab.bsky.social · 30/04/2026
Don’t miss this free meeting taking place in Paris from the Institut Thematique BCRDE @inserm.fr @sfbd.bsky.social , @fsscr.bsky.social on Cell Plasticity Sept 21, 22. Keynotes talks by Sui Huang (Seattle, WA, USA), Jessica Whited (Boston, MA, USA) itbcrde.inserm.fr/index.php?pa...
itbcrde.inserm.fr
Cell Plasticity Symposium 2026 registration - IT Biologie cellulaire, reproduction, développement et évolution
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Maria Alcolea @mariapalcolea.bsky.social · 08/05/2026
This is a lovely smiley face! 😊 Super excited to finally see our recent paper in print! 📖🎉 Check out how the precancerous fibrotic niche 🌱 determines nascent tumour persistence in the current issue of @nature.com🔬 www.nature.com/articles/s41... @gretas90.bsky.social, E.Rojo, @hariajith.bsky.social
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Maria Alcolea @mariapalcolea.bsky.social · 21/04/2026
Excited to see our work featured at Cancer Cell @cp-cancercell.bsky.social ✨ This highlights nascent tumour persistence as a co-evolutionary process between tumour cells and their microenvironment 🌱 www.nature.com/articles/s41... www.cell.com/cancer-cell/...
cell.com
Precancerous niches as gatekeepers of tumor initiation
Clonal competition eliminates most early neoplastic lesions, yet a subset persists and ultimately progresses. In Nature, Skrupskelyte et al. demonstrate that nascent tumors survive by actively reshapi...
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Maria Alcolea @mariapalcolea.bsky.social · 01/04/2026
Studying nascent tumour stages and microtumours 🔬 remains a significant challenge in our field 👩‍🔬 We’re thrilled to partner with FocalPlane to share the "behind-the-scenes" of studying what determines early tumour persistence www.nature.com/articles/s41... Greta Skrupskelyte, Eduardo Rojo
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Maria Alcolea @mariapalcolea.bsky.social · 06/03/2026
Thanks for featuring our work on how emerging tumour remodel their nascent niche 🌱promoting their survival @cam.ac.uk, @scicambridge.bsky.social , @cruk-ci.bsky.social, @pdncambridge.bsky.social www.stemcells.cam.ac.uk/news/alcolea... www.nature.com/articles/s41...
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Reposted by Maria Alcolea
Inigo Martincorena @imartincorena.bsky.social · 05/03/2026
Somatic genomics as a discovery engine for biomedicine - a Perspective in Cell www.sciencedirect.com/science/arti...
sciencedirect.com
Somatic genomics as a discovery engine for biomedicine
Somatic mutations, or genetic changes occurring in cells after conception, are widespread in healthy tissues but are conventionally viewed as signs of…
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Maria Alcolea @mariapalcolea.bsky.social · 04/03/2026
🚨 New paper from our lab just published in Nature🚨 www.nature.com/articles/s41... Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone ✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social
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Maria Alcolea @mariapalcolea.bsky.social · 28/09/2025
Fantastic first day of the Stem Cell and Cancer Fusion Conference! Full of exciting science!
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Reposted by Maria Alcolea
Fusion Conferences @fusionconf.bsky.social · 28/09/2025
Amy, Leanne, Maria & Kate welcomed our #SCC25 attendees to the beautiful Malta this afternoon, a great 4 days ahead for this group, discussing all things Stem Cells & Cancer! @joneslabucsf.bsky.social @mariapalcolea.bsky.social @katemiro.bsky.social
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Maria Alcolea @mariapalcolea.bsky.social · 22/07/2025
📢 Last chance to register! There's still time to sign up for the FUSION Stem Cells and Cancer Conference 🗓️ Registration closes on 31st July — don’t miss out! bit.ly/49sCfJp Co-chairs @joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social
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Maria Alcolea @mariapalcolea.bsky.social · 04/07/2025
⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference! 🧪Share your exciting discoveries with us!! 📍Malta 🗓️Talk Deadline: July 10 🔗http://bit.ly/49sCfJp @joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social
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Reposted by Maria Alcolea
joneslabucsf.bsky.social @joneslabucsf.bsky.social · 04/07/2025
Incredible line-up of speakers! Come join us for the FIRST @fusionconf.bluesky.social #Stemcells and #Cancer conference🔬!!
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Maria Alcolea @mariapalcolea.bsky.social · 04/07/2025
⏳Only 1 week left to submit your talk for the Fusion Stem Cells & Cancer Conference! 🧪Share your exciting discoveries with us!! 📍Malta 🗓️Talk Deadline: July 10 🔗http://bit.ly/49sCfJp @joneslabucsf.bsky.social, Kathrin Plath, @katemiro.bsky.social at @fusionconf.bsky.social
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Maria Alcolea @mariapalcolea.bsky.social · 02/07/2025
One Month to Go!🚨 Countdown for the STEM CELLS & CANCER Fusion Conference — a unique gathering of global leaders sharing their ground breaking research. 🧬Ignite new ideas by Mediterranean Sea-Malta 🏝️ 📅Final Deadline: 31 July 🎤Unmissable speakers...🧵 bit.ly/49sCfJp
bit.ly
Stem Cells & Cancer Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
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Fusion Conferences @fusionconf.bsky.social · 17/06/2025
Our Stem Cells & Cancer Conference Programme is shaping up nicely, this is now available to view on our website, don't miss out on joining @joneslabucsf.bsky.social Kathrin Plath, @mariapalcolea.bsky.social & @katemiro.bsky.social in Malta this September! bit.ly/49sCfJp
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Maria Alcolea @mariapalcolea.bsky.social · 20/06/2025
Not long left to apply! Join us at the Fusion Stem Cells and Cancer conference in Malta. Deadline 31st of July!
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Maria Alcolea @mariapalcolea.bsky.social · 22/05/2025
Remember to join us 🏖️! Fantastic line up 🎆 Meet experts in Stem Cells and Cancer! 🧫 🧪 🔬 Deadline: 31 July Location: Malta
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Reposted by Maria Alcolea
Júlia Bonjoch @juliabonjoch.bsky.social · 23/04/2025
Hi Bluesky community:) Our new manuscript is now available as a preprint!⛅️ biorxiv.org/content/10.1... 1/ Here, we describe a novel BMAL1-YAP complex in epidermal cells, which is hijacked during ageing to control the expression of up-regulated inflammation genes through enhancer binding.🧵
biorxiv.org
BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis
Ageing is characterised by persistent low-grade inflammation that is linked to impaired tissue homeostasis and functionality. However, the molecular mechanisms driving age-associated inflammation rema...
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Maria Alcolea @mariapalcolea.bsky.social · 25/04/2025
Fantastic to see this out! Congratulations @juliabonjoch.bsky.social @guiomarsolanas.bsky.social @aznarbenitahlab.bsky.social @sarawickstrom.bsky.social @katemiro.bsky.social and all those involved!
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Reposted by Maria Alcolea
Maria Alcolea @mariapalcolea.bsky.social · 11/04/2025
⏰ The Early Bird deadline is 17 April — don’t miss your chance to learn from pioneers in Stem Cells & Cancer research. Don’t miss out! Fusion STEM CELLS and CANCER conference! bit.ly/49sCfJp 🧬✨
bit.ly
Stem Cells & Cancer Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
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Maria Alcolea @mariapalcolea.bsky.social · 11/04/2025
⏰ The Early Bird deadline is 17 April — don’t miss your chance to learn from pioneers in Stem Cells & Cancer research. Don’t miss out! Fusion STEM CELLS and CANCER conference! bit.ly/49sCfJp 🧬✨
bit.ly
Stem Cells & Cancer Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
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Maria Alcolea @mariapalcolea.bsky.social · 03/04/2025
Come and join us! Fantastic conference! Deadline looming!
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Reposted by Maria Alcolea
Trevor Graham @trevorgraham.bsky.social · 31/03/2025
Application deadline for our @wellcometrust.bsky.social #CancerEvolution summer school is tomorrow, 1 April 2025. coursesandconferences.wellcomeconnectingscience.org/event/evolut... Our brilliant faculty will cover evo&eco theory, math models, genomics, digital path, clinical trial design & more
coursesandconferences.wellcomeconnectingscience.org
Evolutionary Biology and Ecology of Cancer — 20250630
Evolutionary Biology and Ecology of Cancer
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Reposted by Maria Alcolea
Sendoel Lab @sendoellab.bsky.social · 27/03/2025
The former GRC Stem Cells & Cancer has found its new home in beautiful Malta, fantastic meeting ahead!
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Maria Alcolea @mariapalcolea.bsky.social · 26/03/2025
Incredibly grateful to have met Dave and learned about his oesophageal cancer journey. Grounding our research in real-life experiences is key to making a difference. Huge thanks to @gutscharityuk.bsky.social and @worldwidecancer.bsky.social for their invaluable and continued support!
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Maria Alcolea @mariapalcolea.bsky.social · 25/03/2025
Essential meeting at the crossroads of stem cell biology & cancer! 🔬✨ EARLY CAREER RESEARCH GRANTS AVAILABLE! 📅 Fusion: Stem Cells & Cancer 📍 Malta | September 28, 2025 🚀 Key Deadlines: 🗣️ Early Bird & Talks: Apr 17, 2025 🖼️ Posters: Jul 31, 2025 🔔 Final Registration: Jul 31, 2025 bit.ly/49sCfJp
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Maria Alcolea @mariapalcolea.bsky.social · 25/03/2025
🛫You won’t want to miss us in stunning Malta!🌴🏖️ Get ready to be inspired at the STEM CELLS & CANCER conference. INCREDIBLE LINE-UP of speakers! 🎙️Cedric Blanpain @cedric-blanpain.bsky.social 🎙️Peter Dirks 🎙️Catriona Jamieson… and more 🧵 📅 September 28, 2025 🔗 bit.ly/49sCfJp @fusionconf.bsky.social
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Bartomeu Colom @bartomeucolom.bsky.social · 24/03/2025
'Translating premalignant biology to accelerate non-small-cell lung cancer interception' www.nature.com/articles/s41...
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Reposted by Maria Alcolea
Daryl Jason Verzosa David @djdavid.bsky.social · 18/03/2025
www.nature.com/articles/s41... A new Review out at @sarawickstrom.bsky.social @clemvilleneuve.bsky.social , and @mccreery.bsky.social on tools measuring and perturbing mechanical forces during development. Out now at @naturecellbiology.bsky.social ! Link to read for free: rdcu.be/ed48r
nature.com
Measuring and manipulating mechanical forces during development - Nature Cell Biology
This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...
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Christian Frezza @frezzalab.bsky.social · 23/03/2025
Good morning, all. The first curated issue of papers in #cancermetabolism and #mitochondrialbiology this spring is out. Don't miss it! biomed.news/bims-camemi/... @biomednews.bsky.social "Not everything that is faced can be changed, but nothing can be changed that is not faced." James Baldwin
media.tenor.com
a stick figure is sitting on a stool reading a book
ALT: a stick figure is sitting on a stool reading a book
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Trevor Graham @trevorgraham.bsky.social · 21/03/2025
Ben O'Leary & I are looking for a #postdoc to join us in @cec-icr.bsky.social to work on collaborative @cancerresearchuk.org RadNet project about the interrelationship between genome & epigenome instability and radiotherapy response. Details & apply here: jobs.icr.ac.uk/vacancies/11... @icr.ac.uk
jobs.icr.ac.uk
Postdoctoral Training Fellow - Evolution & Translational Genomics in Sutton | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow - Evolution & Translational Genomics vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Future progre...
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Eric Topol @erictopol.bsky.social · 18/03/2025
Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue journals.plos.org/plosbiology/...
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Sara Wickstrom @sarawickstrom.bsky.social · 10/03/2025
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
nature.com
Measuring and manipulating mechanical forces during development - Nature Cell Biology
This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...
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Reposted by Maria Alcolea
Bartomeu Colom @bartomeucolom.bsky.social · 07/03/2025
'The complex interplay between aging and cancer' www.nature.com/articles/s43...
nature.com
The complex interplay between aging and cancer - Nature Aging
This Review explores the intersection between cancer and aging, illustrating shared causal mechanisms including genome instability, telomere dysfunction, cellular senescence and dysregulated immunity ...
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KatajistoLab @katajistolab.bsky.social · 07/03/2025
1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵
sciencedirect.com
Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin
Mesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…
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Rashmi Priya @rashmi-priya.bsky.social · 06/03/2025
More soon… but for now, feast your eyes on this HEADLESS zebrafish, still rocking a beating HEART— yellow (blood) magenta (endothelium) #Zebrafish #DevBio
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Maria Alcolea @mariapalcolea.bsky.social · 26/02/2025
Fantastic to see this out! PIK3CA mutant response in endothelial cells. Congratulations Helena Sabata, Anne Martinez-Larrinaga, @aangulou.bsky.social, @sandradcastillo.bsky.social , the amazing @grauperalab.bsky.social and all others that made this such a remarkable piece of work.
biorxiv.org
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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CellMech2025 @cellmech2025.bsky.social · 04/02/2025
🚨 We are thrilled to announce our amazing list of keynote speakers!! @PCusachs @GeorgHalder @hirashima0203.bsky.social @iberd.bsky.social @johannaivaska.bsky.social @gijsjekoenderink.bsky.social @laurentnguyen.com @renkawitzteam.bsky.social @Sixt_Lab ...
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Mekayla Storer @storerlab.bsky.social · 11/02/2025
Calling all students. The registration for the European Summer School on Stem Cell Biology and Regenerative Medicine is now open.
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The Company of Biologists @biologists.bsky.social · 04/02/2025
Our latest extraordinary biologist is Sarah Bray, Chair of our Board of Directors. To learn more about Sarah's role and relationship with @biologists.bsky.social, read this interview in @dev-journal.bsky.social: bit.ly/3CEibaX. #100biologists @uniofcam.bsky.social
The Company of Biologists 100 logo to the left and QR code to the right.
 
Portrait of Sarah Bray to the left, text to the right
 
100 extraordinary biologists

Sarah Bray

Sarah Bray is the current Chair of the Board, having been a Director since 2016 and a Professor at the University of Cambridge, UK with a research interest in Notch signalling.

#100biologists #biologists100
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Sandra Blanco Lab @sblancolab.bsky.social · 01/02/2025
Remarkable study from @evamarianovoa.bsky.social lab @crg.eu @naturecomms.bsky.social. Bacteria 🦠🧬 #ribosome tweak #RNAmods contributing to #antibioticresistance 💉. The new NanoConsensus #nanopore tool is a game-changer for studying these changes across species www.nature.com/articles/s41...
nature.com
Native RNA nanopore sequencing reveals antibiotic-induced loss of rRNA modifications in the A- and P-sites - Nature Communications
It remains unclear whether rRNA modifications can be naturally altered in response to antibiotics in bacteria. Here, the authors analyzed direct RNA nanopore sequencing data with an analytical pipelin...
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epithelial mechanics fan club @epimechfc.bsky.social · 03/02/2025
Oost, Koen C., Maurice Kahnwald, ... Sebastien A. Smallwood, Michael B. Stadler, and Prisca Liberali. "Dynamics and plasticity of stem cells in the regenerating human colonic epithelium." biorxiv (2023): 2023-12. doi.org/10.1101/2023.12.18.572103 #EpithelialMechanics
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Sara Wickstrom @sarawickstrom.bsky.social · 29/01/2025
Despite challenging times delighted to see our preprint on how stem cell-specific sphingolipid metabolism controls fate trajectories in the hair follicle published🎉 congratulations Franziska &team and thank you @dfg.de @maxplanckpress.de and UniHelsinki for support! rupress.org/jcb/article/...
rupress.org
Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment | Journal of Cell Biology | Rockefeller University Press
This study identifies a specific role for ceramide synthase 4 (CerS4) in cell fate regulation. Epidermis-specific deletion of CerS4 prevents development of
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Kate Miroshnikova @katemiro.bsky.social · 22/01/2025
Join us for fantastic science on #cancer #stemcells in a beautiful place 🇲🇹 🤩
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The Francis Crick Institute @crick.ac.uk · 23/01/2025
Speakers will include @foadrouhani.bsky.social, @mariapalcolea.bsky.social and @cedric-blanpain.bsky.social
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Maria Alcolea @mariapalcolea.bsky.social · 22/01/2025
✈️Join us in paradise! The stunning Malta will be the perfect setting to stimulate great discussions on Stem Cell and Cancer Biology 🔬 World-leading experts will share their exciting science. 🗓️Fusion Conference Stem Cells & Cancer! September 28, 2025 bit.ly/49sCfJp
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Albert Herms @albertherms.bsky.social · 20/01/2025
We are looking for a postdoc for an ERC funded project at @albertpol.bsky.social Lab at @idibaps.bsky.social in Barcelona. Do you want to use 3D #epithelioids to study the role of lipid droplets against bacterial infections? Come and join us!👇 www.clinicbarcelona.org/uploads/medi...
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epithelial mechanics fan club @epimechfc.bsky.social · 20/01/2025
Chen, D. Y., Crest, J., Streichan, S. J., & Bilder, D. (2019). Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation. Nature communications, 10(1), 3339. #EpithelialMechanics www.nature.com/articles/s41467-019-…
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Edouard Hannezo @ehannezo.bsky.social · 15/01/2025
Excited to see this out - how single cell heterogeneities and cell-cell interactions synergize to drive tissue patterning during regeneration! See thread below!
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