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Barral Lab

@barrallab.bsky.social
1.5K followers 1.8K following 10 posts

Immunology lab at King’s College London and The Francis Crick Institute #Immunology #Lipids #NKT #MAIT

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Reposted by Barral Lab
Journal of Experimental Medicine @jem.org · 09/09/2026
CD1d remodels the tumor-infiltrating myeloid populations controlling anti-tumor immunity. From Lauren Evans, Maria Conde Poole, Patricia Barral @barrallab.bsky.social: rupress.org/jem/article/... Part of our #CancerImmunotherapy 2026 👉 rupress.org/jem/collecti... #CSHAsia
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Reposted by Barral Lab
Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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Reposted by Barral Lab
Journal of Experimental Medicine @jem.org · 20/08/2026
CD1d remodels the tumor-infiltrating myeloid populations controlling anti-tumor immunity. New study from Lauren Evans, Maria Conde Poole, Patricia Barral @barrallab.bsky.social @kingscollegelondon.bsky.social @crick.ac.uk and colleagues: rupress.org/jem/article/... #BreastCancer #TumorImmunology
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Reposted by Barral Lab
Barral Lab @barrallab.bsky.social · 13/08/2026
Our latest paper is out! We went back to our favourite molecule, CD1d, and explored its functions in myeloid cells in tumours. Amazing work from Lauren and Maria, and many thanks to our collaborators and funders @breastcancernow.bsky.social @cruk-cityoflondon.bsky.social doi.org/10.1084/jem....
doi.org
CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity
Evans et al. identify CD1d as a key regulator of myeloid cell diversity in breast cancer. CD1d targeting reshapes tumor immune infiltrates, suppresses tumo
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Reposted by Barral Lab
Waggoner Lab @labwaggoner.bsky.social · 14/08/2026
CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity @jem.org @barrallab.bsky.social @kingscollegelondon.bsky.social @crick.ac.uk rupress.org/jem/article/...
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Reposted by Barral Lab
Journal of Experimental Medicine @jem.org · 13/08/2026
Evans et al. @barrallab.bsky.social identify CD1d as a key regulator of myeloid cell diversity in #BreastCancer. CD1d targeting reshapes tumor immune infiltrates, suppresses tumor growth, & enhances #immunotherapy efficacy, suggesting an actionable pathway for treatment. rupress.org/jem/article/...
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Barral Lab @barrallab.bsky.social · 13/08/2026
Our latest paper is out! We went back to our favourite molecule, CD1d, and explored its functions in myeloid cells in tumours. Amazing work from Lauren and Maria, and many thanks to our collaborators and funders @breastcancernow.bsky.social @cruk-cityoflondon.bsky.social doi.org/10.1084/jem....
doi.org
CD1d remodels the tumor-infiltrating myeloid populations controlling antitumor immunity
Evans et al. identify CD1d as a key regulator of myeloid cell diversity in breast cancer. CD1d targeting reshapes tumor immune infiltrates, suppresses tumo
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Reposted by Barral Lab
Juan Martin Serrano @juanmartin-serrano.bsky.social · 12/08/2026
thanks @natsmb.nature.com for having our paper on the issue cover, ESCRT spirals rock!
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Reposted by Barral Lab
Juan Martin Serrano @juanmartin-serrano.bsky.social · 15/07/2026
Very proud to see this paper out. This is an incredible collaboration with the labs of Wes Sundquist and Adam Frost. @uofubiochem.bsky.social @kingslsm.bsky.social www.nature.com/articles/s41...
nature.com
ESCRT-III assembles around mis-segregated DNA to protect genome stability - Nature Structural & Molecular Biology
The authors show that persistent ultrafine DNA bridges become coated by membranes and the ESCRT-III proteins CHMP1B and IST1, which protect the genome within from damage.
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Thiago Carvalho @cyrilpedia.bsky.social · 15/07/2026
They always do 'Merck’s remigromig could become the first trispecific to market. Its origins date back, however, to an academic exploration of antibody space that started before bispecifics had hit the market.' www.nature.com/articles/d41...
nature.com
Can multispecific biologics break the efficacy ceiling?
A growing pipeline of multispecific antibody therapies are in clinical trials, showcasing novel biological effects as well as potential improvements over multi-agent cocktails.
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Reposted by Barral Lab
Juan Martin Serrano @juanmartin-serrano.bsky.social · 10/07/2026
como te voy a echar de menos elpais.com/cultura/2026...
elpais.com
Julia Luzán, la periodista cultural que no se parecía a nadie
Escribió, para este periódico y para otros medios, sobre todo de arte y de asuntos que tenían que ver con la historia y con la memoria. Estaba siempre atenta a lo que pasaba, y a lo que nos pasaba a q...
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Reposted by Barral Lab
Juan Martin Serrano @juanmartin-serrano.bsky.social · 12/07/2026
columnadigital.com/julia-luzan-...
columnadigital.com
Julia Luzán, una periodista única en cultura - Columna Digital
Julia Luzán, una figura emblemática del periodismo cultural español, dejó un legado imborrable en el ámbito de la literatura y las artes con su fallecimiento a los 78 años en Madrid. Conocida por su p...
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Reposted by Barral Lab
Maruja Torres @marujatorres.bsky.social · 10/07/2026
Ha muerto la amiga junto a la que hice testamento vital. Descansa en paz, querida Julia. Tú, que luchaste tanto. Precioso homenaje de @cosmejuan76.bsky.social elpais.com/cultura/2026...
elpais.com
Julia Luzán, la periodista cultural que no se parecía a nadie
Escribió, para este periódico y para otros medios, sobre todo de arte y de asuntos que tenían que ver con la historia y con la memoria. Estaba siempre atenta a lo que pasaba, y a lo que nos pasaba a q...
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Reposted by Barral Lab
Mikel López Iturriaga @mikeliturriaga.bsky.social · 11/07/2026
Cuando era un jovenzuelo y entré a trabajar en El País de la Tentaciones allá por los noventa, de vez en cuando hacía cosas para Julia en El País Semanal. Siempre me pareció de las personas más amables y receptivas de la redacción. Pena 🙁 elpais.com/cultura/2026...
elpais.com
Julia Luzán, la periodista cultural que no se parecía a nadie
Escribió, para este periódico y para otros medios, sobre todo de arte y de asuntos que tenían que ver con la historia y con la memoria. Estaba siempre atenta a lo que pasaba, y a lo que nos pasaba a q...
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Reposted by Barral Lab
Princess Vimentin PhD | Cancer Biologist @princess-vimentin.bsky.social · 06/07/2026
This is huge! Triple Negative Breast Cancers (TNBCs) are aggressive & disproportionately strike younger women. Historically, TNBCs have limited treatment options. Trodelvy, which targets Trop-2 is now approved in the US for first line treatment of metastatic TNBC. 🧪 www.gilead.com/news/news-de...
U.S. FDA Approves
Trodelvy® for First-Line Treatment of Metastatic Triple-Negative Breast Cancer

- Trodelvy is a New Backbone Therapy and the Only Approved ADC in First-Line mTNBC Across
PD-L1 Status -

- Approval Builds on Trodelvy's Leadership in Second-Line mTNBC and Pre-Treated
HR+/HER2- Metastatic Breast Cancer with More than 75,000 Patients Treated Globally -
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Reposted by Barral Lab
Nature @nature.com · 05/07/2026
A journal trialled paying their reviewers and found it led to faster first editorial decisions – and increased review quality go.nature.com/3RcRfpY
go.nature.com
Why paying peer reviewers works, according to a journal’s editor-in-chief
Nature - A biology journal which paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
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Reposted by Barral Lab
Princess Vimentin PhD | Cancer Biologist @princess-vimentin.bsky.social · 04/07/2026
A summary of the HandMaid’s tale in 2 minutes. I saw the beginning episodes of this. It freaked me out. Things don’t happen all of a sudden. They slowly build. Recall that we are living in a time where Project 2025 is coming alive. #Pinks
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Reposted by Barral Lab
Harmit Singh Malik @harmitmalik.bsky.social · 01/07/2026
😮 @danielgorelick.bsky.social @biologyopen.bsky.social www.nature.com/articles/d41...
nature.com
Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
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Reposted by Barral Lab
Kit Yates @kityates.bsky.social · 18/06/2026
What an amazing story.❤️
bbc.co.uk
Cervical cancer deaths fall to zero in young women given HPV vaccine
A new study finds that hundreds of lives have been saved since school-age girls were offered the HPV jab in 2008.
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Reposted by Barral Lab
David Ho @davidho.bsky.social · 18/06/2026
Vaccines are humanity's greatest scientific achievement.
bbc.co.uk
Cervical cancer deaths fall to zero in young women given HPV vaccine
A new study finds that hundreds of lives have been saved since school-age girls were offered the HPV jab in 2008.
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Reposted by Barral Lab
Otto English @ottoenglish.bsky.social · 18/06/2026
Such good news. Human beings are capable of magical and wonderful things. www.bbc.co.uk/news/article...
bbc.co.uk
Cervical cancer deaths fall to zero in young women given HPV vaccine
A new study finds that hundreds of lives have been saved since school-age girls were offered the HPV jab in 2008.
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Reposted by Barral Lab
Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 05/06/2026
Wow 😧 “Members of the American Diabetes Association (ADA) were escorted by police out of the convention center in New Orleans during the organization's annual meeting on Friday as they handed out copies of an editorial criticizing Trump administration changes to U.S. biomedical research.”
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Reposted by Barral Lab
Carl T. Bergstrom @carlbergstrom.com · 06/06/2026
The criticism of Trump, Kennedy, and Bhattacharya that was so subversive that the ADA had to eject the Editor-in-Chief of their flagship journal from their annual meeting for sharing it? Prior today it had fewer than 1000 views. Do your thing.
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Reposted by Barral Lab
Dr. Lucky Tran @luckytran.com · 02/06/2026
Incredible! Scientists receive a rare standing ovation after announcing that a new treatment can double the survival time for pancreatic cancer, the deadliest cancer which was once considered “undruggable.” When we fund and support science, we can achieve anything! (Video: Dr. Wish Dhillon)
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ana-farias.bsky.social @ana-farias.bsky.social · 24/04/2026
Very pleased to see my postdoc work studying respiratory viral infections and lung metastasis published in @pnas.org! Many thanks to @cjohansson-lab.bsky.social and @ila07.bsky.social labs at @imperialnhli.bsky.social and @crick.ac.uk! www.pnas.org/doi/10.1073/...
pnas.org
Type I interferons induced upon respiratory viral infection impair lung metastatic initiation | PNAS
Metastatic breast cancer accounts for 7% of cancer-related deaths, with the lungs being a common site of cancer spread. In parallel, lower respirat...
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Reposted by Barral Lab
Institut Pasteur | 130 years of biomedical research @pasteur.fr · 21/04/2026
Institut Pasteur mourns the passing of Philippe Bousso, a renowned immunologist, head of the Dynamics of Immune Responses unit and director of the Immunology Department. His pioneering imaging work transformed our understanding of immune cells in vivo. 1/3
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Cecilia Johansson @cjohansson-lab.bsky.social · 24/04/2026
Very pleased to share our collaborative work with Ilaria Malanchi's lab. We have combined our lab's specialities and studied respiratory viral infections, type I IFNs and metastatic cancer spread to the lung. www.pnas.org/doi/10.1073/... @ila07.bsky.social @imperialnhli.bsky.social
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Barral Lab
Jan Rosenow @janrosenow.bsky.social · 19/03/2026
Spain's renewables build-out has structurally decoupled its electricity prices from gas markets. Gas now sets the price in only 15% of hours, compared to 90% in Italy. Countries that invested early in clean power are far less exposed to fossil fuel price shocks. Those that didn't now pay the price.
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Reposted by Barral Lab
David Ho @davidho.bsky.social · 12/03/2026
The 2026 National Science Foundation budget is $8.75 Billion.
nytimes.com
First 6 Days of Iran War Cost U.S. $11.3 Billion, Pentagon Says
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Reposted by Barral Lab
MwahahahahahadScientist @mads100tist.bsky.social · 12/03/2026
The ERC budget for 2026 is 2.7 billion euros 🧪
NYT headline: First 6  days of Iran War Cost US $11.3 billion, Pentagon says
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Edward Nirenberg @enirenberg.bsky.social · 08/03/2026
It's crazy to me how the papers that get published today could easily have been 3 or 4 papers even a decade or two ago. The amount of information they are saturated with is intense.
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Stefan Marciniak @profmarciniak.bsky.social · 15/02/2026
“The gender pay gap, which stands at £2,548 a year, means that women have effectively worked for free so far this year, the TUC said” This is a stain on the country Ask yourself, are your mother, sister, daughter, wife less valuable than their male colleagues?
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Christian Zierhut @zierlab.bsky.social · 01/02/2026
This is an absolute outrage that should be discussed as widely as possible. I expect that this failing government will try and use the MRC to divert funding from academic research into commercial enterprises, killing UK research in the process.
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Mark A. Hanson @hansonmark.bsky.social · 31/01/2026
Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate). Listen, I get that UKRI wants to pivot. But killing both at once is devastating. Let's hope at least one opens by summer... #AcademicSky
researchprofessionalnews.com
MRC instructs grant review boards to slash funding rates - Research Professional News
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls
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Alan McNally @alanmcn1.bsky.social · 01/02/2026
I am sorry. We all knew the three buckets were coming. We are all prepared for a shift in priority. But this message does nothing for all the UK scientists dependent on project grant funding. It doesn’t actually give any information www.ukri.org/news/open-le...
ukri.org
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
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Willem van Schaik @wvschaik.bsky.social · 30/01/2026
More cheery news from UKRI 'MRC instructs grant review boards to slash funding rates' www.researchprofessionalnews.com/rr-news-uk-r...
researchprofessionalnews.com
MRC instructs grant review boards to slash funding rates - Research Professional News
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls
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Willem van Schaik @wvschaik.bsky.social · 28/01/2026
Update on UKRI funding situation. Summary: it is mostly bad news, and with significant uncertainties around new funding model.
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Stefan Marciniak @profmarciniak.bsky.social · 28/01/2026
Has the MRC research funding ‘pause’ been covered by any major news network? It feels like it should be a major news story
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Marisol Soengas @msmelanoma.bsky.social · 20/01/2026
Absolutely “We need to talk about salaries in science” www.nature.com/articles/d41...
nature.com
We need to talk about salaries in science
Academia too often has a ‘passion first, money second’ culture. Overcoming this mindset is crucial for building a happy career.
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Margot Finn @eicathomefinn.bsky.social · 07/01/2026
'Despite all their difficulties, universities remain an enormous and irreplaceable national asset. As well as educating millions of people, they generate about £24bn in export earnings, which is about 1% of GDP – more than aircraft manufacturing and legal services combined'. 1/2
theguardian.com
The Guardian view on universities: Labour needs a clearer plan | Editorial
Editorial: Ministers promised a ‘change of approach’, but their new tax could tip weaker institutions over the edge
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Caetano Reis e Sousa @reisesousalab.bsky.social · 12/12/2025
Taking advantage of a natural experiment, this follow-up by @pascalge.bsky.social of their earlier study in Nature on the beneficial effects of shingles vacination on dementia. Very cool stuff! www.cell.com/cell/fulltex...
cell.com
The effect of shingles vaccination at different stages of the dementia disease course
A natural experiment found that herpes zoster vaccination reduced the occurrence of mild cognitive impairment and deaths due to dementia, indicating that the vaccine may slow the progression of dement...
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Reposted by Barral Lab
James Briscoe @jamesbriscoe.bsky.social · 05/12/2025
BBC News - Top UK scientist says research visa restrictions endanger economy www.bbc.com/news/article...
bbc.com
Top UK scientist says research visa restrictions endanger economy
Prof Sir Paul Nurse says the UK is "shooting itself in the foot" with its visa system for researchers.
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Elisa Fadda @elisafadda.bsky.social · 05/12/2025
"Why do we put hurdles in the way of the people that are actually going to drive our economy? It makes zero sense." Prof Sir Paul Nurse, Nobel prize winning scientist, says the UK's scientific future is being put at risk www.bbc.co.uk/news/article...
bbc.co.uk
Top UK scientist says research visa restrictions endanger economy
Prof Sir Paul Nurse says the UK is
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ImmuNoah's Ark (Noe Rodriguez) @immunoah.bsky.social · 05/12/2025
We need to apply @nc3rs.bsky.social principles, ensure animal welfare & do the best possible by research animals. But let's not confuse people or ourselves by thinking they're dispensable. Why we have to continue with animal testing for medical research | Letters www.theguardian.com/science/2025...
theguardian.com
Why we have to continue with animal testing for medical research | Letters
Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments
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Caetano Reis e Sousa @reisesousalab.bsky.social · 01/12/2025
Key points on the need for continued animal use in scientific research. www.theguardian.com/science/2025...
theguardian.com
Why we have to continue with animal testing for medical research | Letters
Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments
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Dr M @ivalaine.bsky.social · 26/11/2025
Vaccinating boys and girls. It works bitches.
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Ginny Barbour @ginnybarbour.bsky.social · 26/11/2025
“There were no cervical cancer cases diagnosed in women aged <25 years in 2021 – the first time that this has occurred in data going back to 1982. This remarkable achievement is almost certainly due to the impact of HPV vaccination.” From report.cervicalcancercontrol.org.au #vaccinationsaveslives
report.cervicalcancercontrol.org.au
2025 Cervical Cancer Elimination Progress Report | C4
Australia’s progress towards the elimination of cervical cancer as a public health problem
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Ian M. Mackay, PhD (he/him) 🦠🤧🧬📑🦟🧀 @mackayim.bsky.social · 26/11/2025
Frikkin amazing stuff.
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Rita Strack @ritastrack.bsky.social · 25/11/2025
Today is the International day for the elimination of violence against women. In 2024, an estimated 50,000 women and girls were killed by intimate partners or family members worldwide. That is 137 women and girls every day. One every ten minutes. www.un.org/en/observanc...
un.org
International Day for the Elimination of Violence against Women | United Nations
The International Day for the Elimination of Violence against Women aims to create awareness of the fact that violence against women is a human rights violation that impedes progress in many areas, in...
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Doctors Without Borders / Médecins Sans Frontières (MSF) @msf.ca · 25/11/2025
#Sudan: We call on the RSF to protect health facilities and staff, following the death of a Ministry of Health colleague during a shooting at Zalingei hospital. For the second time this year, we have withdrawn staff to ensure their safety. ow.ly/O8VW50XxNcx
ow.ly
Sudan: MSF calls for protection of health facilities and staff after health worker killed | Doctors Without Borders / Médecins Sans Frontières (MSF ...
MSF calls for protection of health workers and facilities after a colleague was killed at Zalingei Hospital in Central Darfur, disrupting care.
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