Researchers in the Basic Sciences Division track evolutionary origins for an essential protein

Dr. Michael Emerman “You align priorities to favor the trainees (so) that what is good for the trainees will end up being good for the lab” Emerman on successful mentoring, Virology Unm…

How antimicrobial peptides embedded within larger proteins arise remains unclear. This study resurrects ancient proteins to reveal how antimicrobial peptides emerged and diversified in mammalian lacto...

Genetic variation in viruses is well known to arise from polymerase-driven nucleotide misincorporation. However, insertion and deletion (indel) mutations that occur at lower, largely unknown, frequenc...

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Creating accurate graphs and performing statistical analyses can be challenging for those who lack coding experience. This Community Page introduces grafify online, a free, browser-based app for gener...

Adaptive potential determines how populations respond to environmental change. This study compiles evolvability estimates from over 170 multicellular species, revealing substantial variation across th...

Viral populations evolve as ‘negative selection’ removes mutants with harmful changes and ‘positive selection’ preserves mutants with advantageous changes. How do viruses with small genomes, like tymo...

Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

Abstract. To identify novel host factors essential for orthoflavivirus replication, we performed proteomic profiling of endoplasmic reticulum fractions iso

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Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...

Flavivirus maturation is enabled by asymmetric rearrangement of the virus envelope proteins.

The Basic Sciences Postdoctoral Fellowship Award was established in 2026 to honor and support outstanding postdoctoral trainees, based primarily on their initial postdoctoral work at Fred Hutch.

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Enteric viruses act as age-distorters, with infection severity tied to aging hallmarks and consequences.

Plasmacytoid dendritic cells (pDCs) produce robust type I interferons (IFN-I) within hours of viral sensing, while epithelial cells at mucosal surfaces mount a delayed response dominated by type III i...

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

What OMB’s Proposed Federal Financial Assistance Rule Means in Practice