iiinova — where your digital self keeps evolving

Reposted by Joe Hamley

MRC Weatherall Institute of Molecular Medicine @imm.ox.ac.uk · 5h

#WIMMReads🧪 Milne, Hughes and Davies Groups have developed a technology that helps reveal how genetic variants linked to disease affect our genes. 👉https://www.imm.ox.ac.uk/news/nat-gen-mapping-variants #AcademicSky @rdm.ox.ac.uk @medsci.ox.ac.uk

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Reposted by Joe Hamley

Bora Ozcan @boraaozcan.bsky.social · 22h

Very happy to have helped with this project led by Joe!

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Reposted by Joe Hamley

Roman Doll @romanmdoll.bsky.social · 22h

Check out this new work from the lab, led by Joe! It’s been really impressive seeing this project develop — huge congrats to everyone!

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Reposted by Joe Hamley

James Davies @jojdavies.bsky.social · 07/10/2026

Delighted to see our latest paper out in @natgenet.nature.com ! The brilliant @jhamley98.bsky.social developed MCCv, allowing chromatin architecture to be visualised at base-pair resolution for each allele—a powerful way to identify functional genetic variants. www.nature.com/articles/s41... 🧵

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Joe Hamley @jhamley98.bsky.social · 23h

1/4🧵 Really excited to see that a major part of my PhD work has now been published in Nature Genetics! 🎉 In this study, we developed Micro Capture-C variant-to-function (MCCv): a method to map how genetic variants alter gene regulation at single-allele resolution. www.nature.com/articles/s41...

nature.com

Single-allele nanoscale mapping of regulatory variants - Nature Genetics

This study uses high-resolution, allele-specific chromatin architecture to identify causal gene-regulatory mechanisms in inflammatory diseases and uncovers a mechanism by which a neo-CTCF site promote...

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Reposted by Joe Hamley

Roman Doll @romanmdoll.bsky.social · 20/12/2025

Excited to share that a part of my PhD work is online now on BioRxiv! www.biorxiv.org/content/10.6... We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells. Thread 👇

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Reposted by Joe Hamley

The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · 05/11/2025

Not from Tron or a psychedelic wallpaper. This exquisite pic reveals chromatin at base-pair resolution, captured by #ListerFellow James Davies and collaborators🤩 "For the first time, we can see how the genome's control switches are physically arranged inside cells." @jojdavies.bsky.social

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Joe Hamley @jhamley98.bsky.social · 05/11/2025

So exciting to see this finally out! Incredible work by Hangpeng pushing the resolution of MCC even further.

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Reposted by Joe Hamley

Davies Lab @davieslab.bsky.social · 27/08/2025

We’re really excited to see Hangpeng Li present our latest work at the CSH Mechanisms of Eukaryotic Transcription meeting.

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