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Aditya Kunjapur

@kunjapur.bsky.social
929 followers 1.1K following 51 posts

Thomas Willing Early Career Assoc. Professor, U. Delaware | #Synbio with newer-to-nature building blocks | Formerly @Texas @MIT @HMS www.kunjapurlab.org

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Reposted by Aditya Kunjapur
Ran Blekhman @blekhman.bsky.social · 23/09/2026
We have to stop using "paper count" as a useful scientific metric. More writing output no longer means more knowledge gained www.washingtonpost.com/education/20...
washingtonpost.com
One professor’s AI-assisted output: 200 papers and 14 books this year
An online platform removed 257 papers written or co-written by the University of Chicago’s Nicholas Polson after other academics raised questions.
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Reposted by Aditya Kunjapur
Joint Genome Institute @jgi.doe.gov · 14/09/2026
From our FY26 Functional Genomics call: Speciality chemicals like non-standard amino acids could be made more efficiently in microbes with hardier enzymes. @kunjapur.bsky.social will use biodesign to make pathway enzymes more thermostable. Full portfolio: jointgeno.me/FGFY26
Community Science Program announcement congratulating Aditya Kunjapur of the University of Delaware, with his portrait, project title, and a stylized DNA graphic.

Transcribed Text:

Community Science Program (FY26)

Congratulations

to our CSP Functional Genomics Call recipients!

JGI

Aditya Kunjapur

University of Delaware

Engineering thermostability of aldehyde and amine modifying enzymes for orthogonality in lysates of mesophiles
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Aditya Kunjapur @kunjapur.bsky.social · 11/09/2026
New PET upcycling work in Science Advances: BHET/MHET readily enter E. coli, letting us directly couple PET glycolysis to whole-cell biocatalysis. Fun collaboration with Dion Vlachos, and congrats to first author Roman Dickey! www.science.org/doi/10.1126/...
science.org
Robust cellular transformations of PET deconstruction products by import of glycol esters
Efforts to transform polyethylene terephthalate (PET) deconstruction products using live cells have been limited by terephthalic acid (TPA) uptake. Here, we used an intracellular carboxylate reduction...
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Aditya Kunjapur @kunjapur.bsky.social · 06/07/2026
Consider checking out our latest review article if you're interested in how a wave of efforts in amino acid biosynthesis are creating new opportunities in genetic code expansion
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Aditya Kunjapur @kunjapur.bsky.social · 12/06/2026
Our latest paper describes a single bacterial strain that can make different Phe derivatives from supplemented aromatic aldehydes or carboxylic acids and incorporate them into target proteins via genetic code expansion Congrats to Shelby Anderson and co-authors www.nature.com/articles/s41...
nature.com
Combined biosynthesis and site-specific incorporation of phenylalanine derivatives from aryl aldehydes or carboxylic acids - Nature Communications
Genetic code expansion can be limited by the need to supply non-standard amino acids. The authors design bacteria that perform integrated steps of converting supplemented aldehydes to L-phenylalanine ...
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Reposted by Aditya Kunjapur
Jenn Brophy @jennbrophy.bsky.social · 04/06/2026
Excited to share our new preprint "Genetic code expansion enables plant-directed control of bacterial activity", a fantastic collaboration with @kunjapur.bsky.social lab! www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Aditya Kunjapur
Tae Seok Moon @taeseokmoon.bsky.social · 08/05/2026
Thank Bob Langer & AIChE again for this honor and featuring us: César de la Fuente, Aditya Kunjapur, Albert Keung & Ashish Kulkarni @delafuentelab.bsky.social @kunjapur.bsky.social giving.aiche.org/impact/stori...
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Aditya Kunjapur @kunjapur.bsky.social · 05/11/2025
I had an amazing time yesterday visiting @vdlorenzo.bsky.social and hearing about the many exciting projects underway in his lab. Our evening stroll through the heart of Madrid and dinner of tapas made for an unforgettable experience
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Aditya Kunjapur @kunjapur.bsky.social · 04/11/2025
It's an honor to visit @vdlorenzo.bsky.social and colleagues at El Centro Nacional de Biotecnología in beautiful Madrid, España. Me alegra estar aquí
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Aditya Kunjapur @kunjapur.bsky.social · 03/10/2025
Interested in using microbes to degrade plastics? We made the discovery that two breakdown products of PET, MHET and BHET, are readily taken up by E. coli cells Our latest preprint exploits this surprise to realize improvements in cell-based upcycling www.biorxiv.org/content/10.1...
biorxiv.org
Robust cellular transformations of PET deconstruction products by import of glycol esters
Efforts to transform polyethylene terephthalate (PET) deconstruction products using live cells have been limited by terephthalic acid (TPA) uptake. Here, we used an intracellular carboxylate reduction...
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Aditya Kunjapur @kunjapur.bsky.social · 13/08/2025
My students have become very good at cloning. Now I can be in two continents at once this fall
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Reposted by Aditya Kunjapur
Sabyasachi Sen @sunny-sen.bsky.social · 17/07/2025
Excited to announce our new methods paper in Methods in Enzymology! We share our pipeline for building high-diversity DNA libraries & exploring protein stability in E. coli. Free access until Sept 4: authors.elsevier.com/a/1lRkeHRzCX... Updated, companion preprint: www.biorxiv.org/content/10.1...
authors.elsevier.com
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Aditya Kunjapur @kunjapur.bsky.social · 17/07/2025
Exciting to see this collaborative work about modeling soil microbiomes from the Kuehn, Mani, and Tikhonov labs published today Also delighted to have lead author Kiseok Lee start his postdoc in our lab Check out the paper below!
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Aditya Kunjapur @kunjapur.bsky.social · 29/06/2025
Looking forward to the amazing program & making new connections at the 17th International Symposium on Biocatalysis and Biotransformations (Biotrans 2025) starting today in Basel I'm honored to present our work on Tuesday at 15:15 in the non-canonical amino acids session #biocatalysis
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Reposted by Aditya Kunjapur
Pablo Ivan Nikel @pabnik.bsky.social · 22/06/2025
Wrapping up a fantastic #ME16 #Copenhagen — a success by all measures! Honored to co-chair the meeting w/I. Borodina, M. Chang, A. Mirończuk, C. Vickers, V. Šťovíček, Y. Zhou, M. Köpke & M. Herrgård & to work w/an outstanding team of colleagues, engaging communities & topics all around the world
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Aditya Kunjapur @kunjapur.bsky.social · 16/06/2025
Congrats on completing your PhD @kiseokmicro.bsky.social! And welcome to our lab - very excited to work with you
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Aditya Kunjapur @kunjapur.bsky.social · 15/06/2025
I'm enjoying the start of the International Metabolic Engineering 16 #ME16 meeting in Copenhagen this week Thanks to the organizers for providing a chance to share our work Thanks to my students for taking these pics Looking forward to meeting other attendees
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Reposted by Aditya Kunjapur
Conor McClune @cmcclune.bsky.social · 11/06/2025
Today in Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III & deBz-deoxy-Taxol #SingleCell #secmet 🧬🧪🌾
nature.com
Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature
An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...
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Aditya Kunjapur @kunjapur.bsky.social · 09/06/2025
It is a real honor and delight to be hosted by @pabnik.bsky.social at DTU Biosustain! Looking forward to meeting folks & sharing info/ideas
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Aditya Kunjapur @kunjapur.bsky.social · 25/05/2025
Trump Has Cut Science Funding to Its Lowest Level in Decades www.nytimes.com/interactive/... ^ Useful info in this article about the level of funding of various NSF directorates/programs relative to the 10Y avg by this time of year
nytimes.com
Trump Has Cut Science Funding to Its Lowest Level in Decades
The lag in funding extends far beyond D.E.I. initiatives, affecting almost every area of science: chemistry, computing, engineering, materials and more.
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Aditya Kunjapur @kunjapur.bsky.social · 23/05/2025
With the state of US scientific funding it seems like an inappropriate time to celebrate anything But in the last week thanks to years of dedication from my students we were recognized through the Roberta Colman and Gerard Mangone awards, & tenure. Thank you to those who made it possible (1/3)
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Aditya Kunjapur @kunjapur.bsky.social · 23/05/2025
If you're curious how the first 5 amino acids of newly generated protein N-termini can affect protein stability in E. coli, then check out our latest preprint We find new patterns of exceptions to the usual N-end rule Kudos to Sunny Sen & co-authors #synbio #protein_degradation
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Reposted by Aditya Kunjapur
Thomas Arnesen @natmachinery.bsky.social · 23/05/2025
Protein degradation in E. coli via N-terminal degradation signals (degrons) defined by the @kunjapur.bsky.social lab. @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Combinatorial mutagenesis of N-terminal sequences reveals unexpected and expanded stability determinants of the Escherichia coli N-degron pathway
Although it is known that penultimate N-terminal residues can influence protein stability by the N-degron pathway, there has not been a comprehensive effort to document nor predict these effects for n...
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Reposted by Aditya Kunjapur
Nature Microbiology @natmicrobiol.nature.com · 06/05/2025
🚨OUT NOW Engineered orthogonal and obligate bacterial commensalism mediated by a non-standard amino acid by @kunjapur.bsky.social et al. #MicroSky 🦠🔧 www.nature.com/articles/s41...
nature.com
Engineered orthogonal and obligate bacterial commensalism mediated by a non-standard amino acid - Nature Microbiology
A genetically engineered microbial symbiosis based on synthetic auxotrophy is created, with potential implications as a biocontainment strategy.
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Aditya Kunjapur @kunjapur.bsky.social · 01/05/2025
A more accurate statement than my original post: It seems there may be few known pairs of microbial species, outside of obligate intracellular symbionts/parasites, where one relies exclusively on another. Using a blend of synthetic and chemical biology, we designed such an interaction
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Aditya Kunjapur @kunjapur.bsky.social · 01/05/2025
It seems there are no free-living organisms known to rely exclusively on one other organism for their survival Until perhaps now Check out our latest publication in @natmicrobiol.nature.com to see how we designed an exclusive microbial reliance using GCE rdcu.be/ekepI 1/2
rdcu.be
Engineered orthogonal and obligate bacterial commensalism mediated by a non-standard amino acid
Nature Microbiology - A genetically engineered microbial symbiosis based on synthetic auxotrophy is created, with potential implications as a biocontainment strategy.
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Aditya Kunjapur @kunjapur.bsky.social · 08/02/2025
This move could singlehandedly dismantle American leadership in science and technology innovation. It goes into effect on Monday. How will universities adjust their budgets to support critical ongoing research?
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Aditya Kunjapur @kunjapur.bsky.social · 07/02/2025
See here for an exciting development in genome engineering for genetic code expansion and for understanding the pliability of components involved in protein translational termination - from the Isaacs Lab www.nature.com/articles/s41...
nature.com
Engineering a genomically recoded organism with one stop codon - Nature
Ochre, a strain of Escherichia coli engineered to have a single stop codon, enables reassignment of four codons for non-degenerate functions, such as incorporation of non-standard amino acids into pro...
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Reposted by Aditya Kunjapur
Rahul K @theresearch.bsky.social · 17/01/2025
2025-01-12 Issue of #engineeredlivingmaterials feed biomed.news/bims-enlima/... h/t @biomednews.bsky.social includes @kunjapur.bsky.social lab's preprint @biorxivpreprint.bsky.social on combined biosynthesis and site-specific incorporation of phenylalanine derivatives in engineered bacteria
Overview of the engineered biosynthesis and incorporation platform. A single strain was designed to express two to four enzymes for the biosynthesis of phenylalanine derivates from supplemented acid or aldehyde precursors. The biosynthesized nsAA was then incorporated into a target protein using amber stop codon suppression and an orthogonal translation system. Source: https://www.biorxiv.org/content/10.1101/2024.12.17.628963v1.fullBiological materials are built with a limited number of building blocks based on polysaccharides, proteins, and minerals. A diversity of structures leads to a diversity of functions in tooth, bone, artery wall, tendon, spider web, beak, feather, wool, fingernail, tree, cotton, beetle carapace, lobster shell, snail shell, mussel shell, and the skeleton of the glass sponge (clockwise from top). Primary source: https://www.science.org/doi/10.1126/science.aat8297
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Aditya Kunjapur @kunjapur.bsky.social · 11/01/2025
Let's go horns 🤘🏾 #hookem
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Aditya Kunjapur @kunjapur.bsky.social · 10/01/2025
Bill Bentley from Maryland kicks off our microbial communities session by discussing mediated electrochemical probing for mAbs and cells #MASBN
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Aditya Kunjapur @kunjapur.bsky.social · 10/01/2025
Day 2 of #MASBN kicks off with our keynote speaker Chris Voigt discussing his inspiring work on engineering microbes for environmental release #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
Our last speaker in the New to the Mid Atlantic session at this year's #MASBN symposium is @saramol.bsky.social who recently started her lab at U. Maryland. Cool results on asymmetric cell division for patterning #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
We're excited to hear about electromicrobiology from @electromicrobe.bsky.social who recently started his lab @princetonupress.bsky.social #MASBN #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
Next up at MASBN is @victoriagmuir.bsky.social , my new colleague at @udelaware.bsky.social who is studying how cells navigate complex environments and host-pathogen interactions #MASBN #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
In our New to the Mid Atlantic session, we're pleased to have Ophelia Venturelli tell us about multi-scale dynamics in gut microbial communities @oventurelli2.bsky.social #MASBN #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
And the MASBN Symposium is now in full swing as Sherry Gao from UPenn kicks us off
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Reposted by Aditya Kunjapur
Victoria Grace Muir, Ph.D. @victoriagmuir.bsky.social · 09/01/2025
Super excited to join for the 2025 Mid-Atlantic Synthetic Biology Network Symposium today and tomorrow! Welcome to #UDelaware to all of the attendees! #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 09/01/2025
It's a frigid but otherwise lovely winter day here at U. Delaware where we are gearing up to host the 2025 Mid-Atlantic Synthetic Biology Network Symposium. A big welcome to our 230 attendees, and a big thank you to our sponsors NSF, DBI, IFF, NIIMBL, & more #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 06/01/2025
Genetic code expansion - meet synthetic ecology! We can design an exclusive reliance of one engineered bacterial strain on another mediated by a non-standard AA Such exclusive reliances between free-living organisms aren't known in nature Tremendous work led by NSF GRFP recipient Amanda Forti
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Aditya Kunjapur @kunjapur.bsky.social · 23/12/2024
Our one-pot biocatalytic cascade for synthesis of Phe derivatives is now available online at ChemCatChem chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/... Also online now on bioRxiv is our larger story where we couple this pathway to GCE tools in live cells www.biorxiv.org/content/10.1...
chemistry-europe.onlinelibrary.wiley.com
A One‐Pot Biocatalytic Cascade to Access Diverse L‐Phenylalanine Derivatives From Aldehydes or Carboxylic Acids
Non-standard amino acids (nsAAs) that are L-phenylalanine derivatives with aryl ring functionalization have long been harnessed in natural product synthesis, therapeutic peptide synthesis, and divers....
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Aditya Kunjapur @kunjapur.bsky.social · 11/12/2024
Check out our latest pre-print on building biocatalytic cascades for the synthesis of phenylalanine derivatives for applications in genetic code expansion www.biorxiv.org/content/10.1... Andrew Buller's lab at Wisconsin is also doing terrific work in this area - stay tuned for that too #synbio
biorxiv.org
A One-Pot Biocatalytic Cascade to Access Diverse L-Phenylalanine Derivatives from Aldehydes or Carboxylic Acids
Non-standard amino acids (nsAAs) that are L-phenylalanine derivatives with aryl ring functionalization have long been harnessed in natural product synthesis, therapeutic peptide synthesis, and diverse...
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Aditya Kunjapur @kunjapur.bsky.social · 09/12/2024
In the last 2 weeks my feed on X has turned into almost entirely conspiracy theories and content NSFW. In contrast, my feed on BlueSky is increasingly showing more relevant scientific papers. So glad this site exists
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Aditya Kunjapur @kunjapur.bsky.social · 07/12/2024
Ready for the SEC title game to avenge the one loss for Texas, the one game I happened to attend this season #hookem A throwback youtu.be/Mm63vZ8Cakw?...
youtu.be
Bevo charges Uga | Sugar Bowl Mascot Altercation
YouTube video by Hylights
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Aditya Kunjapur @kunjapur.bsky.social · 04/12/2024
Proud of my wife for having led this effort to expand access to gene therapies for sickle cell disease www.fiercehealthcare.com/payers/cms-n...
fiercehealthcare.com
CMS names two drug manufacturers for cell and gene therapy model
The Centers for Medicare & Medicaid Services has successfully negotiated agreements with two drug manufacturers to participate in the newly created Cell and Gene Therapy Access Model. | The two drugs ...
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Reposted by Aditya Kunjapur
Ross D. Jones, PhD @jonesr18.bsky.social · 02/12/2024
Final @ebrc.org SPA workshop of the year on Wed! Please RT/share! 🧬 Are you a student or postdoc interested to learn more about project design and selection? 📺 Attend our workshop + panel discussion about choosing a research topic! 🔗 Register here: forms.gle/yxfxon4WoEPB...
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Aditya Kunjapur @kunjapur.bsky.social · 22/11/2024
Interested in #synbio & in the Mid-Atlantic? The next regional SynBio symposium will be on Jan 9-10 @udelaware.bsky.social Register for free thanks to NSF & other sponsors below. www.midatlanticsynbionetwork.org Great lineup of speakers. 170+ registered so far. Registration closes on 11/27. (1/2)
midatlanticsynbionetwork.org
Mid-Atlantic Synthetic Biology Network – Maryland, Delaware, Washington DC, Virginia, North Carolina, South Carolina & Georgia
Maryland, Delaware, Washington DC, Virginia, North Carolina, South Carolina & Georgia
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Reposted by Aditya Kunjapur
Calin Plesa @calin.bsky.social · 12/11/2024
Started creating a synthetic biology starter pack. Still missing many so reply here if I forgot you or someone else. go.bsky.app/SjfpxTK #synbio
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Aditya Kunjapur @kunjapur.bsky.social · 15/11/2024
www.theatlantic.com/magazine/arc... The analysis and suggestions here are reasonable in my opinion, as someone who is generally skeptical towards proposals to redefine merit in college admissions
theatlantic.com
How the Ivy League Broke America
The meritocracy isn’t working. We need something new.
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Aditya Kunjapur @kunjapur.bsky.social · 27/10/2024
Nice to be at #AIChE2024 in San Diego. Check out our posters and talks Monday through Wednesday
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