Reposted by Veit HornungIannacone Lab @iannaconelab.bsky.social · 18/10/2025Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat... 22010
Reposted by Veit HornungIvan Zanoni @lozanzi.bsky.social · 19/10/2025#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v-hornung.bsky.social &co show @cp-cell.bsky.social that RNase T2 & PLDs generate #TLR7 & #TLR8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing!sciencedirect.comPseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagementRecognition of exogenous RNA by Toll-like receptors (TLRs) is central to pathogen defense. Using two distinct binding pockets, TLR7 and TLR8 recognize… 0267
Reposted by Veit HornungTobias Komar @t-komar.bsky.social · 09/08/2025Excited to share the first paper of my PhD, published in the Journal of Biological Chemistry. Huge thanks to all authors, especially to co-first author Stefan Bauernfried, Alex Horswill‘s lab and @mannlab.bsky.social, and my supervisor @v-hornung.bsky.social. www.jbc.org/article/S002...jbc.orgInflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureusInterleukin-1β (IL-1β) is a pivotal mediator of innate immunity, essential for orchestrating the acute inflammatory response. While the canonical activation of IL-1β involves cleavage of its inactive ... 184
Reposted by Veit HornungKeystone Symposia @keystonesymposia.bsky.social · 16/09/2025⏰ Deadline: Sept 17 (11:59pm MDT) Early-career scientists - submit an abstract or apply for a scholarship for #KSAutoImmune26: Autoimmunity & Autoinflammation 🧬 📅 Jan 19–22, 2026 | Breckenridge, CO 👉 keysym.us/KSAutoimmune26 youtu.be/nMsJANbMb-w #KSAutoImmune26 @v-hornung.bsky.socialyoutu.beAutoimmunity & Autoinflammation Meeting PromoYouTube video by KeystoneSymposia 033
Reposted by Veit HornungPavel Kielkowski @pavelkielkowski.bsky.social · 23/09/2025The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social 1137
Reposted by Veit HornungRebsamen Lab @UNIL @rebsamenlab.bsky.social · 28/01/2025We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland. Registrations open March 1 - Attendance limited to 150 participants. More info: wp.unil.ch/immunobiolog... #ImmunoSkywp.unil.chSymposium immunobiology 13617
Reposted by Veit HornungJournal of Experimental Medicine @jem.org · 24/01/2025New: Sato, Miyake @UTokyo_News_en and colleagues report that the lack of RNase T2 activates TLR13, the sensor of bacterial 23S ribosomal RNAs, leading to the accumulation of tissue-protective Kupffer cells. buff.ly/4hw6kL0 Companion study by @v-hornung.bsky.social buff.ly/4jG49Gy 052
Reposted by Veit HornungWaggoner Lab @labwaggoner.bsky.social · 24/01/2025RNase T2 plays an important role in limiting self-RNA recognition by preventing erroneous activation of TLR13 @jem.org @v-hornung.bsky.social doi.org/10.1084/jem.... doi.org/10.1084/jem.... 0123
Reposted by Veit HornungSorek Lab @soreklab.bsky.social · 23/01/2025Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10 www.cell.com/cell/abstrac...cell.comStructure-guided discovery of viral proteins that inhibit host immunityLarge-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no... 120174
Reposted by Veit HornungLouis-Jeantet Foundation @louisjeantetfdn.bsky.social · 21/01/2025VEIT HORNUNG @v-hornung.bsky.social @genecenter-lmu.bsky.social is awarded the 2025 Collen-Jeantet Prize for Translational Medicine for his important contributions to our understanding of how foreign nucleic acids and other non-self signals trigger the innate immune system. 3277
Reposted by Veit HornungPavel Kielkowski @pavelkielkowski.bsky.social · 16/01/2025Proteoforms matter! We show how AMPylation impacts PLD3 proteolytic processing and catalytic activity. Congratulations to Laura Hoffmann and thanks to all collaborators @jaelab.bsky.social, @v-hornung.bsky.social, @hellmichgroup.bsky.social and Wei Xiang lab! www.biorxiv.org/content/10.1...biorxiv.orgAMPylation regulates PLD3 processingThe 5’-3’ exonuclease phospholipase D3 (PLD3) is a single-pass transmembrane protein undergoing sequential post-translational modifications (PTM) by N -glycosylation, AMPylation and proteolytic cleava... 1173
Reposted by Veit HornungAude Bernheim @audeber.bsky.social · 09/12/2024Registration now open for the EMBO Workshop: Immune System of Bacteria !!!! www.sisb2025.conferences-pasteur.org/home Joins us in Institut Pasteur, Paris, April 8-10th. 15238
Reposted by Veit HornungBrian Ferguson @viropractor.bsky.social · 29/11/2024We are recruiting an associate or full Professor of Infection and/or Immunity to the school biological sciences in Cambridge. Full details here: www.jobs.cam.ac.uk/job/49381/ #immunology #virologyjobs.cam.ac.ukAssociate Professor/Professor of Infection and/or Immunity - Job Opportunities - University of CambridgeAssociate Professor/Professor of Infection and/or Immunity in the Department of Pathology at the University of Cambridge. 27168
Reposted by Veit HornungGene Center Munich @LMU Munich @genecenter-lmu.bsky.social · 19/11/2024Don't miss this opportunity for your next career step: 021
Veit Hornung @v-hornung.bsky.social · 19/11/2024📢 Postdoc opening! 📢 @soreklab.bsky.social and we are looking for outstanding candidates for a position at the intersection of computational biology & innate immunity. Dive into impactful research in two dynamic fields. Interested? Let’s connect! 👇 www.genzentrum.uni-muenchen.de/career/postd...genzentrum.uni-muenchen.dePostdoctoral Position (f/m/x) in Immunology / Biochemistry / Computational Biology - Gene Center Munich - LMU Munich 02724