Density-dependent regulation of collective order through collision sensing and collision-induced reversals provides a navigational advantage to Pseudomonas aeruginosa during surface colonization and n...

A comparative analysis of multiomics data from embryonic and adult tissues of Atlantic salmon and rainbow trout reveals developmental and tissue-specific constraints shaping regulatory evolution follo...

Stem cell differentiation is controlled by manipulating RNA condensates.

Meiring, Mahapatra et al. show that expanded microtubule lattice conformations, such as those induced by small-molecule taxanes, can lead to the release of GEF-H1 and thus induce RhoA activation.

Microscopists raise concerns about inappropriate AI usage in Nikon's microscopy contest-winning video. Nikon stands their ground, citing no policy breach.

A scrappy science project led to a significant discovery: two new species of a rare organism that could elucidate a fundamental transition in the history of life on our planet.

Summary: The placenta is the only mammalian organ that harbors a cancer-like genome while remaining functional and healthy. This Review highlights its high mutational load, structural variants, aneupl...

The dielectric environment and membrane dipole potential are key electrostatic properties of biological membranes, which modulate the function of membrane-associated proteins. If and how these propert...

Incendiamoeba cascadensis can replicate at 145° F, breaking the heat tolerance record for eukaryotes, a domain of life that includes plants and animals.

When stressed, this comb jelly reverts to a larval form, then matures again when favorable conditions return

Animal cells extensively remodel their cytoskeleton during differentiation and can notably switch between two major motility modes: flagellum-based swimming and actin-based crawling. We previously sho...

Guan et al. show that bacteria use protein homologs with different material properties to regulate biomolecular condensates. By tuning the abundance of these proteins in heterotypic assemblies, bacteria balance condensate dynamics and stability, thereby maintaining fitness during stress.

The majority of plant seeds have the special ability to almost completely dry out and yet remain viable. While most living cells die with a 90% loss of water, cells in seeds enter a biological state o...

The country singer was an advocate for vaccines, public health, literacy and marginalized communities.

Ghosh et al. report that the anti-apoptotic Bcl2 family protein, Bcl-xL, primarily found in the outer mitochondrial membrane, interacts with endoplasmic reticulum resident protein inositol 1,4,5-trisphosphate receptors. This interaction facilitates local calcium transfer at the ER-mitochondria contacts but does not impact mitochondrial calcium transfer due to global changes in cellular calcium.

Published in Nucleus (Vol. 17, No. 1, 2026)

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.

In a debate that has been building for years, a growing coalition of reformers has concluded that the research project grant (RPG) approach used by many science funders in the United States and based ...

Caliskan, Haas et al. present a cross-species subcellular proteomic atlas of pancreatic islets, revealing conserved organelle organization across human, pig, and mouse. The study uncovers disease-associated remodeling of vesicular trafficking, granule acidification machinery, and mitochondrial metabolism in a mouse model of type 2 diabetes.

Somatic mutations are linked to diseases, yet their prevalence and relevance in health remain poorly defined. Technological advancements now enable us to delineate how tissue-specific somatic mutations drive adaptive metabolism across the lifespan and uncover hidden determinants of health and drivers of diseases.

Claude Science reproduced Figures 1–14 of a breast cancer bioinformatics paper using Opus alone — 2 skills, 0 MCP calls. Here's what worked, what didn't, and why it matters.

The hyphae-to-yeast morphological transition promotes dissemination of the pathogen Candida albicans, but the mechanisms underlying this process are poorly defined. By identifying a bacterial metaboli...

Neutrophil extracellular traps (NETs) feature a branched chromatin architecture whose origin and function remain unknown. We found that NET branching is mediated by RAD51, a protein generating DNA jun...

The signals that cells use to switch genes on have remained almost unchanged across 2 billion years of evolution, but the ones used to switch genes off vary dramatically from one branch of life to ano...

Polyploidization, the consequence of genome doubling, is a macromutation that reshapes genomes, phenotypes, and ecological interactions. Polyploidi...

Maslennikova et al. identify the ER membrane protein CLCC1 as an interaction partner of the dystonia-linked AAA+ ATPase Torsin1A. Torsin1A sustains the function of CLCC1, which is proposed to facilitate fusion of the nuclear envelope during NPC biogenesis by forming an oligomer that promotes lipid bilayer approach and remodeling.

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing an enteroendocrine mother cell every ninth division.