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Abstract. Crossover formation during meiosis generates genetic diversity. In many species most crossovers display interference, meaning they are spaced mor

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DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

DNA damage checkpoints are key regulatory signaling cascades that arrest cell cycle progression upon DNA damage or upon DNA replication stalling and allow time for repair or correction. Failure to eli...

Creative Community Engagement project led by Deborah Humphrey, and Karina Patfield highlighted on BBC news. Words from the Waiting Room offers cancer patients, survivors, and supporters a safe enviro...

The theme of World Cancer Day 2025 is “United by Unique”, which places people at the centre of care and their stories at the heart of the conversation. Today the Sussex Cancer Research Centre (SCR...

imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy. This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated downregulation ...