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Esashi Lab

@esashilab.bsky.social

187 followers 160 following 7 posts

Sir William Dunn School, University of Oxford, Interested in genome stability, homologous recombination, chromosome, centromeres esashilab.wordpress.com

Posts Replies Media

Esashi Lab @esashilab.bsky.social · 03/03/2026

Huge congratulations to Brian on smashing his DPhil defence - now Dr Leung! 🎓 And massive thanks to the wonderful examiners @thedownslab.bsky.social and @jansenlab.bsky.social for such engaging discussions!

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Esashi Lab @esashilab.bsky.social · 02/08/2025

Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social‬

rdcu.be

Centromeres as minefields: host–virus warfare

Cell Research - Centromeres as minefields: host–virus warfare

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Esashi Lab @esashilab.bsky.social · 25/02/2025

We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️ www.cell.com/cell-reports...

cell.com

The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability

Graham et al. demonstrate that BRCA2 and PALB2 protect centromere integrity in non-cancerous cells through distinct mechanisms, partly counteracting the mismatch repair factor MLH1. In cancer cells, B...

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