iiinova — where your digital self keeps evolving

Titia Sixma @titiasixma.bsky.social · 12/06/2026

Andrea Murachelli shared his BRCA1-A structures and mechanism: lnkd.in/eBT8_G5W. With new probe for metallo-DUBs from Farid El Oualid they expose BRCA1-A as ubiquitin chain-shortener. @nkinl.bsky.social @oncodeinstitute.bsky.social back to back with @zeqiraj.bsky.social: doi.org/10.64898/202...

lnkd.in

This link will take you to a page that’s not on LinkedIn

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Titia Sixma @titiasixma.bsky.social · 21/04/2026

the deadline is rapidly approaching:

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Netherlands Cancer Institute @nkinl.bsky.social · 20/02/2026

We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...

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marcelvanvugt.bsky.social @marcelvanvugt.bsky.social · 17/01/2026

This meeting comes highly recommended! Register soon!

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Titia Sixma @titiasixma.bsky.social · 04/11/2025

This is wonderful!! Many many thanks to Friedrich and everyone else for the enormous amount of work you have done to ensure the future of cryo-EM research in the Netherlands!

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Netherlands Cancer Institute @nkinl.bsky.social · 30/09/2025

“It’s amazing to be the very first person to understand something at such a miniscule scale”. From October 1st, junior group leader Wout Oosterheert will give a boost to fundamental cancer research at the Netherlands Cancer Institute ➡️ www.nki.nl/news-events/...

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Francesca Mattiroli @fmattiroli.bsky.social · 21/09/2025

The latest work from ours and @vram142.bsky.social lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and @palindromephd.bsky.social. Learning so much from Vijay’s amazing technologies! RT

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Titia Sixma @titiasixma.bsky.social · 18/09/2025

Congratulations to everyone but especially Venda & Sylvie for this nice work and thanks to Andrea Murachelli in my lab for his analyses

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Titia Sixma @titiasixma.bsky.social · 31/07/2025

Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics ‪@oncodeinstitute.bsky.social‬, ‪@nkinl.bsky.social‬

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Netherlands Cancer Institute @nkinl.bsky.social · 27/06/2025

Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research. Congrats Thijn! 🎉 @thijnbrummel.bsky.social Full article ➡️ bit.ly/40p4KnK

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Aafke Gros @aafkegros.bsky.social · 23/05/2025

In the context of our @reviewcommons.org revision process, I'm happy to announce Microscopy Nodes v2.2.0! This packs lots of new fun features, including new color management 🌈, clearer transparency handling 🫥, custom default settings 🔧 and more! Preprint at doi.org/10.1101/2025...

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Aafke Gros @aafkegros.bsky.social · 23/05/2025

This is accompanied by a new set of tutorials showing exactly how you can start making beautiful microscopy visualizations in @blender.org! Following along is also easy with the example OME-Zarr @openmicroscopy.org datasets 😄 Find the tutorials here: www.youtube.com/playlist?lis...

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Arjen Jakobi @cryotud.bsky.social · 26/05/2025

LocScale-SURFER is now also available for quick install via the ChimeraX toolshed: cxtoolshed.rbvi.ucsf.edu

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Barack Obama @barackobama.bsky.social · 15/04/2025

Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.

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Luijsterburglab @luijsterburglab.bsky.social · 09/04/2025

A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com

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Carl T. Bergstrom @carlbergstrom.com · 01/04/2025

Trump's 3/27 executive order targets the Smithsonian for advancing "the view that race is not a biological reality but a social construct." Trump argues that the exhibit's statement, below, is unscientific. He's wrong. As a biology professor and population geneticist, I agree with every word of it.

“Race does not provide an accurate representation of human biological variation,” the statement reads. “Humans are not divided biologically into distinct continental types or racial genetic clusters. Instead, the Western concept of race must be understood as a classification system that emerged from, and in support of, European colonialism, oppression, and discrimination.”

“It thus does not have its roots in biological reality, but in policies of discrimination,” the statement says. “Because of that, over the last five centuries, race has become a social reality that structures societies and how we experience the world. In this regard, race is real, as is racism, and both have real biological consequences.”

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Rob van Montfort @robvanmontfort.bsky.social · 29/03/2025

Fondly remember Jan for his enthusiasm, rigorous science, and the kind person that he was.

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Elisa Fadda @elisafadda.bsky.social · 20/03/2025

"The rejection of grant applications or the alteration of the published record on account of the use of terms such as ‘bias’, ‘gender’, ‘ethnicity’ and even ‘female’ is unacceptable. EMBO Press joins other journals in not allowing such changes" 💪🏻👏🏻👏🏻👏🏻 www.embopress.org/doi/full/10....

embopress.org

Under pressure | EMBO reports

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

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Titia Sixma @titiasixma.bsky.social · 17/03/2025

It's infinitely sad to see what is happening. the disregard of laws, advice and justice in our immigration policy plans, the total implosion of human values overseas. I feel just a bystander reeling in shock.

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Titia Sixma @titiasixma.bsky.social · 20/02/2025

Today Jan Drenth would have been 100 years, but sadly he passed away last week. He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD.

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Dominique Baker @bakerdphd.bsky.social · 30/01/2025

Today, the same as every other damn day, trans rights are human rights

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Netherlands Cancer Institute @nkinl.bsky.social · 24/01/2025

Are you graduating this year and ready to start your career in the most meaningful way? This is your chance to get on board. #PhD #CancerResearch ➡️ nki.nl/careers-study/phd-students/nki-phd-program-2025/

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Francesca Mattiroli @fmattiroli.bsky.social · 24/01/2025

I am really excited to have the opportunity to continue to do science at the Hubrecht Institute @hubrechtinstitute.bsky.social! Thank you for the support!

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Aafke Gros @aafkegros.bsky.social · 15/01/2025

Microscopy Nodes is now up on bioRxiv! 🚀 This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev). High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬 www.biorxiv.org/content/10.1...

FIB-SEM dataset visualized with Microscopy Nodes, data from Mocaer et al 2023

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Titia Sixma @titiasixma.bsky.social · 08/01/2025

The NKI call for PhD students is now open, with more information on our project on the website, More info: bit.ly/3O4bOjq

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Titia Sixma @titiasixma.bsky.social · 17/12/2024

Despite the black picture below, we're really happy to have this illuminating story online! Careful molecular mechanistic from Niels and others in the lab work giving unexpected biological insight!

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Titia Sixma @titiasixma.bsky.social · 16/12/2024

We have an opening for a PhD student, for a cryo-EM/biochemistry project at the interface of ubiquitin and DNA repair. Enthousiasm and experience with protein biochemistry and/or structural biology really important. Recruitment will fall under the the NKI PhD program, please see below

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Micha Rapé Lab @micharapelab.bsky.social · 26/11/2024

Excited to report our discovery of an important component of the oxidative stress response: the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress. www.biorxiv.org/content/10.1...

biorxiv.org

Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12

The oxidative stress response is centered on the transcription factor NRF2 and protects cells from reactive oxygen species (ROS). While ROS inhibit the E3 ligase CUL3-KEAP1 to stabilize NRF2 and elici...

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Malte Gersch @maltegersch.bsky.social · 25/11/2024

Could't think of a better inaugural post here. Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology. Congratulations Kim, Kai, and all authors! www.nature.com/articles/s41...

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Sjors Scheres @sjorsscheres.bsky.social · 25/11/2024

It was Tony Crowther whose advice I still hold dearly: "Don't worry about the journal, it will still be the same science you are publishing somewhere else."

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Emilio Lecona @emlecona.bsky.social · 21/11/2024

Great meeting of the RepliFate doctoral Network, lots of science and fun, great interactions and even better organization by @titiasixma.bsky.social

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Damian Dalle Nogare @damiandn.bsky.social · 18/11/2024

Next up, microscopy nodes for Blender, made by @grosoane.bsky.social, which lets you import microscopy images as efficient voxel representations for generating animations (ie below, from EMPIAR-10982). I've had a lot of fun playing around with it the last couple of weeks. github.com/oanegros/Mic...

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Rune Busk Damgaard @rbdamgaard.bsky.social · 15/11/2024

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn

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Chromatin Haiku @chromatinhaiku.bsky.social · 15/11/2024

STK19 Transcription coupled repair With TFIIH #ChromatinHaiku www.cell.com/cell/fulltex... www.cell.com/cell/fulltex... www.cell.com/molecular-ce...

Graphical abstract for one of the papers

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Titia Sixma @titiasixma.bsky.social · 14/11/2024

Great to see this out: STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment Great collaboration with Jurgen Marteijn and Anisha Ramadhin; All biochem.and #cryoEM by Shun-Hsiao Lee: www.cell.com/molecular-ce...

cell.com

STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment

Transcription-coupled nucleotide excision repair (TC-NER) is crucial to repair DNA damage that blocks RNA polymerase II. Ramadhin and Lee et al. identify STK19 as a core TC-NER factor that plays a cru...

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