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Susana Simões-Sousa

@susana-sousa.bsky.social

23 followers 34 following 1 posts

Postdoctoral Training Fellow @thedownslab.bsky.social @icr.ac.uk The Downs Lab website: thedownslab.org

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Susana Simões-Sousa @susana-sousa.bsky.social · 17/09/2025

Our latest work is now out in Cell Reports!

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Reposted by Susana Simões-Sousa

The Downs Lab @thedownslab.bsky.social · 04/07/2025

@kezlane.bsky.social Karen Lane presented work she did with @susana-sousa.bsky.social and Noa Amin on ARID1A and G4s (not her main project - watch this space for a project coming out soon on cohesin dynamics in SWI/SNF deficient cells)

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Reposted by Susana Simões-Sousa

The Downs Lab @thedownslab.bsky.social · 27/05/2025

New preprint from the lab on ARID1A, G quadruplexes, and repair: www.biorxiv.org/content/10.1...

biorxiv.org

ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin

ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. It is challenging to predict how ARID1A loss impacts cancer therapy response because it participates ...

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