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Helfrid Hochegger

@helfridh.bsky.social
181 followers 239 following 15 posts

Professor @gdsc-sussex; studying how cells divide and how we get them to stop dividing in cancer. Interested in genetics, imaging, evolution, bioinformatics, python, rust. www.hocheggerlab.org

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Helfrid Hochegger @helfridh.bsky.social · 02/02/2026
I sure hope this is fake news! economictimes.indiatimes.com/nri/study/uk...
economictimes.indiatimes.com
UK research councils pause applications for major research grants - The Economic Times
Three major UK research councils have temporarily halted applications for several funding programmes, sparking concerns among scientists about potential research spending cuts. The Medical Research Co...
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Maxim Greenberg @maxvcg.bsky.social · 04/12/2025
Every year, I inch further and further towards the southwest of this graph.
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Human Frontier Science Program @hfspo.bsky.social · 14/11/2025
From Sendai to Kyoto: the HFSP Science Summit Japan 2025 connected outstanding scientists and young researchers in a week of collaboration and discovery. 📖 Read the full story → zurl.co/5eYb5 🧪 #sts #HFSPSummitJapan
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Iain Cheeseman @iaincheeseman.bsky.social · 07/11/2025
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly. wi.mit.edu/news/alterna...
wi.mit.edu
Alternate proteins from the same gene contribute differently to health and rare disease | Whitehead Institute
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...
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Iva Tolić @ivatolic.bsky.social · 21/10/2025
Two back-to-back stories on mitosis led by my incredible postdoc @krunovuk.bsky.social at @institutrb.bsky.social, in which we challenge the gliding model of CENP-E-driven chromosome congression! Today in @natcomms.nature.com doi.org/10.1038/s414... doi.org/10.1038/s414...
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Iain Cheeseman @iaincheeseman.bsky.social · 20/10/2025
Today @anthropic.com released PubMed integration for Claude. No hallucinations. Just real science, real data. As a beta tester, this has been game changing— a supercharged research tool. Here are 6 prompts that will transform how you search the literature. A 🧵 www.anthropic.com/news/claude-...
anthropic.com
Claude for Life Sciences
Discover how Claude accelerates life sciences research with new scientific connectors, skills, and improved performance for drug discovery and clinical work.
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Anne Carpenter @drannecarpenter.bsky.social · 10/10/2025
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further
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Alexis Barr @alexisbarr.bsky.social · 07/10/2025
Just over one week until this opportunity closes! If you’re an ambitious computational scientist looking for a Postdoc position, apply now
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Mcclelland lab @mcclellandlab.bsky.social · 02/10/2025
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
crukradnet.colcc.ac.uk
Investigating the interplay between DNA damage repair mechanisms, genomic instability and radiotherapy resistance - CRUK RadNet
Investigating the interplay between DNA damage repair mechanisms, genomic instability and radiotherapy resistance Primary supervisor: Sarah McClelland, Queen Mary University of London Secondary superv...
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Mathew Jones @jonesmjk.bsky.social · 25/09/2025
Fantastic meeting with an excellent line up of speakers. Come join us for the Australian Cell Cycle meeting in Melbourne.
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Aaron Straight @astraight.bsky.social · 18/08/2025
@currentbiology.bsky.social has always been one of my favorite journals but I think they have now outdone themselves www.cell.com/current-biol.... And picked up by the @nytimes.com as well! www.nytimes.com/2025/08/18/s...
cell.com
Periodic excretion patterns of seabirds in flight
Uesaka and Sato report on the excretion patterns of seabirds in the open ocean determined using a rear-facing video logger.
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Helfrid Hochegger @helfridh.bsky.social · 20/09/2025
As students come back to campus in the UK, 8% of female students are likely to experience rape during their undergraduate years, especially in the first months of their studies. revoltsexualassault.com/wp-content/u...
revoltsexualassault.com
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Alexis Barr @alexisbarr.bsky.social · 18/09/2025
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...
imperial.ac.uk
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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Chris Lord and Andrew Tutt’s Lab Institute of Cancer Research @icrlordlab.bsky.social · 19/09/2025
We're hiring ! Specifically....we are seeking to appoint a creative and motivated Postdoctoral Training Fellow to study how drug resistance emerges in homologous recombination defective (HRD) breast cancers and how this could be targeted. jobs.icr.ac.uk/vacancies/13...
jobs.icr.ac.uk
PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) in Chelsea | The Institute of Cancer Research
View details and apply for this PDTF - Homologous Recombination Defective Cancers ( Profs Chris Lord and Andrew Tutt) vacancy in Chelsea . Salary: Dependent on relevant Postdoctoral exp...
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A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 10/09/2025
Thanks for sharing our work @bladoux.bsky.social (you just made the lead author @marcoenriquez18.bsky.social very happy 😊)
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Jasmeen Oberoi @jasmeenoberoi.bsky.social · 04/09/2025
Research is never a solo effort. It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities. We know what it takes to beat blood cancer. #BloodCancerAwarenessMonth @bloodcanceruk.bsky.social @sussexbcr.bsky.social @sussexcancer.org 🩸
Blood cancer awareness month. Image from Blood Cancer UK campaign. "It takes Science and Stubbornness".
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Mathew Jones @jonesmjk.bsky.social · 01/09/2025
Checkout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
rdcu.be
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...
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Mike Lee @theleelab.bsky.social · 15/08/2025
I’m excited to highlight our latest paper, just published in Cell 🎉 We report the existence of a previously uncharacterized signaling pathway that is responsible for activating cell death upon loss of gene expression. 1/n 🧪 www.cell.com/cell/fulltex...
cell.com
RNA Pol II inhibition activates cell death independently from the loss of transcription
When RNA polymerase II (RNA Pol II) is inhibited, the inhibition is sensed and signaled to mitochondria, leading to programmed cell death independently of the loss of RNA Pol II transcription activity...
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Antony W. Oliver (Tony) @antonywoliver.bsky.social · 30/08/2025
... and this one too! Again, quite amazing microscopy. Major congrats to Maria + colleagues for getting this story online.
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Helfrid Hochegger @helfridh.bsky.social · 28/08/2025
Excited to share our new @NatureComms paper! We developed C-604, a selective inhibitor of Greatwall kinase, and discovered that cancer cells' sensitivity to it depends on a simple ratio: B55α/Greatwall expression levels. www.nature.com/articles/s41...
nature.com
The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells - Nature Communications
The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify B55α and Greatwall levels as biomarkers…
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Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · 23/05/2025
We are pleased to annouce that a 3.5-year PhD position is available in the GDSC, for a project jointly supervised by Prof. Hochegger and Dr. Oliver. For additional details, inc. candidate eligibility, and how to apply: www.sussex.ac.uk/study/fees-f...
sussex.ac.uk
Life Sciences PhD Genome Stability - Understanding and Targeting Cell Cycle Control in Cancer : University of Sussex
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Helfrid Hochegger @helfridh.bsky.social · 21/05/2025
Tony Oliver’s and my lab have a joint phd position available to investigate mitotic entry control mechanisms Please forward to prospective students! Thank you url.uk.m.mimecastprotect.com/s/ukMTCoy6DT...
url.uk.m.mimecastprotect.com
PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer at University of Sussex
At jobs.ac.uk, you can apply for a PhD Studentship: Understanding and Targeting Cell Cycle Control in Cancer. Explore our diverse range of PhD opportunities today.
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Adrian Saurin @adesaurin.bsky.social · 01/04/2025
Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes. www.nature.com/articles/s41...
nature.com
A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores - Nature Communications
Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and ...
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Sean Carroll @seanmcarroll.bsky.social · 28/03/2025
Lovely retrospective for Dan Dennett.
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Anthony Chalmers @profajchalmers.bsky.social · 18/01/2025
Thanks to the @simplyoncology.bsky.social guys for this opportunity to talk about everything high grade glioma!
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Fillip Port @crisprflydesign.bsky.social · 03/01/2025
Interesting 🧵 about publishing in Math. tl;dr: All papers in Math are preprinted. When publishers ask big $ for subscriptions or OA, mathematicians simply say "No thanks, we read these papers already on arXiv." Publishers then force unis to buy Math journals by bundling them with Bio journals.
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Adam Frank @adamfrank4.bsky.social · 27/12/2024
Here is my deep dive into Life, the Universe and Everything with Lex Fridman. Discussions include Astrobiology, Technosignatures, the Physics of Life, Quantum Mechanics and the Philosophy of Science. Big fun 3 hr + conversation. www.youtube.com/watch?v=yhZA...
youtube.com
Adam Frank: Alien Civilizations and the Search for Extraterrestrial Life | Lex Fridman Podcast #455
YouTube video by Lex Fridman
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Helfrid Hochegger @helfridh.bsky.social · 24/12/2024
Christmas dumplings.
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Helfrid Hochegger @helfridh.bsky.social · 20/12/2024
Book of the year for me!
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Mcclelland lab @mcclellandlab.bsky.social · 14/11/2024
Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...
meetings.embo.org
Chromosome Segregation and Aneuploidy
Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …
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Helfrid Hochegger @helfridh.bsky.social · 15/12/2024
Sunday lunch: Fitattensuppe
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Miguel Godinho Ferreira @miguelgf.bsky.social · 05/12/2024
Our last study👇- loss of #telomerase drives #cancer #regression through dual mechanisms! In #zebrafish #melanoma, tumors collapse via tumor-autonomous pathways (apoptosis, cell-cycle arrest, differentiation) and nontumor-autonomous #immune rejection. Go Fish 🐟! www.sciencedirect.com/science/arti...
sciencedirect.com
The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma
Most cancers re-activate telomerase to maintain telomere length and thus acquire immortality. Activating telomerase promoter mutations are found in ma…
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Helfrid Hochegger @helfridh.bsky.social · 14/12/2024
favourite podcast series this year: therestishistory.com/48-the-frenc... Fascinating, how history repeats itself!
therestishistory.com
48. The French Revolution - The Rest is History
0.75x 1x 1.25x 1.5x 2x 0:0057:04 48. The French Revolution Apple PodcastsGoogle PodcastsPlayer EmbedShare Leave a ReviewListen in a New WindowDownloadSoundCloudStitcherSubscribe on AndroidSubscribe vi...
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The Downs Lab @thedownslab.bsky.social · 13/12/2024
We are looking for someone to join our lab as a researcher (scientific officer). Advert and information on applying is here: jobs.icr.ac.uk/vacancies/10... It's a great team and a wonderful place to work!
jobs.icr.ac.uk
Scientific Officer - Epigenetics and Genome Stability in Chelsea | The Institute of Cancer Research
View details and apply for this Scientific Officer - Epigenetics and Genome Stability vacancy in Chelsea . Salary : Commencement on the salary range is subject to comparable skills and exp...
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